cdk7/cyclin h/mnat1

CDK12-IN-E9 is a cell cycle protein kinase (CDK) inhibitor with anticancer and antitumor activity that can be used in the study of breast cancer.

CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor with an IC50 of less than 5 nM. It exerts antiproliferative effects on the MDA-MB-468 cell line by blocking the cell cycle and inhibiting DNA replication.

CDK6/PIM1-IN-1 is a balanced, potent dual inhibitor of CDK6 (IC50: 39 nM) and PIM1 (IC50: 88 nM), also showing inhibitory activity on CDK4 (IC50: 3.6 nM). It significantly inhibits the proliferation of acute myeloid leukemia (AML) cells, arrests the cell cycle in G1 phase, induces cell apoptosis, and demonstrates anti-AML activity.

JSH-150 is a highly selective CDK9 inhibitor with an IC50 of 1 nM.