c11

Mito-apocynin (C11) is a mitochondria-targeting antioxidant that works by targeting and neutralizing reactive oxygen species (ROS) produced during cellular respiration. Triphenylphosphonium bromide has been found to be effective in preventing mitochondrial dysfunction, which is a major cause of the aging process and various diseases. It has anti-inflammatory, anti-apoptotic and antioxidant activities.

C-11 is a tubulin inhibitor and functions as an ADC cytotoxin, exhibiting cytotoxicity for carcinoma cell lines.

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α/β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α/β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).

C11:0-CoA (C11:0-coenzyme A) is a derivative of coenzyme A.

LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist of the GPR174 receptor with an EC50 value of 34 nM.

Thalidomide-4-OH-C11-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), comprising Thalidomide-4-OH and the corresponding linker. Thalidomide-4-OH-C11-OH acts as a Cereblon ligand to recruit CRBN protein and serves as a key intermediate for synthesizing complete PROTAC molecules, such as PROTAC GPX4 degrader-4.

Thalidomide-O-C11-acid is a synthetic E3 ligase ligand-linker conjugate, featuring a cereblon ligand derived from Thalidomide and a single linker, and is utilized in the synthesis of PROTAC [Proteolysis Targeting Chimeras].

Pomalidomide-C11-NH2 is a derivative of pomalidomide that acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN) and is used to recruit cereblon protein. Pomalidomide-C11-NH2 can be attached via a linker to a protein ligand, forming a PROTAC.

Thalidomide-O-amido-C11-COOH (Compound IMiD acid 1) is a compound that acts as an E3 ligase ligand and linker for the CRBN (Cereblon) conjugate. This compound is useful in synthesizing PROTACs targeting the degradation of DOT1L.

Thalidomide-amine-C11-acid is an E3 ligase ligand-linker conjugate composed of Thalidomide 5-fluoride and a linker. This compound is utilized in the synthesis of JQAD1.

Pomalidomide-C11-azide is a synthetic E3 ligase ligand-linker conjugate (E3ligaseligand-linker conjugate) used for synthesizing PROTACBRD3 degrader-1.

IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.

Thalidomide-5-O-C11-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].

Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-based cereblon ligand for CRBN protein recruitment, capable of conjugation to a protein ligand via a linker to create PROTACs [1].

Pomalidomide-C11-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide used to recruit the CRBN protein. This compound can be conjugated with a linker to the protein ligand to assemble a PROTAC [1].

Pomalidomide-5-C11-NH2 hydrochloride is a Pomalidomide-derived cereblon (CRBN) ligand that facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to create a PROTAC [1].

C11-PEG4-alcohol is a linker composed of an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain enhances the compound's solubility in aqueous media. The hydroxyl group can be further derivatized or replaced with other reactive functional groups.

C11-PEG9-alcohol is a linker consisting of an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain enhances the compound's solubility in aqueous media. The hydroxyl group can be further derivatized or replaced with other reactive functional groups.

C11-PEG6-alcohol (3,6,9,12,15-Pentaoxahexacosan-1-ol) is a linker featuring an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain enhances the compound's solubility in aqueous media. The hydroxyl group can be further derivatized or replaced with other reactive functional groups.

1,2,3-Triundecanoyl Glycerol (Standard) is the standard substance of 1,2,3-Triundecanoyl Glycerol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1,2,3-Triundecanoyl Glycerol is a cosmetic-ready triglyceride with gluconeogenic and ketogenic capabilities that mobilizes large amounts of odd-chain fatty acids to maintain blood glucose levels in fasted rats and prevent the formation of ketosis.

METHYL UNDECANOATE (Standard) is the standard substance of METHYL UNDECANOATE, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Methyl undecanoate is a natural product found in Daphne odora.

(S)-Desmethyl-NNC112 ((+)-Desmethyl-NNC112) is a selective PET radioligand that binds to D-dopamine receptors.

BFC1108 targets Bcl-2 and converts it to a pro-apoptotic protein, inhibits the growth of triple-negative breast cancer xenografts with high Bcl-2 expression, inhibits breast cancer lung metastasis, and induces apoptosis of Bcl-2-expressing cancer cells.

AC1115 is a highly effective and selective antiviral compound targeting SARS-CoV-2 Mpro and the host lysosomal cysteine protease cathepsin L (CTSL), exhibiting potent antiviral activity.