bis ​peg4 ​nhs ester

Bis-PEG4-NHS ester is a noncleavable, 4-unit PEG linker used for antibody-drug conjugation (ADC).

N-Mal-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based bifunctional linker used for synthesizing Proteolysis Targeting Chimeras (PROTACs) [1].

Bis-(N,N'-PEG4-NHS ester)-Cy5 is an alkyl/ether-based linker compound used in the synthesis of PROTACs [1].

N-(Azido-PEG4)-N-bis(PEG4-NHS ester), a PEG-based PROTAC linker, is an essential component in PROTAC synthesis [1].

N-Boc-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

N-Desthiobiotin-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG) derived linker utilized in the synthesis of PROTACs [1].

SS-bis-amino-PEG4-NHS ester, a four-unit PEG linker with cleavable properties, is utilized in crafting antibody-drug conjugates (ADCs) [1].

DBCO-N-bis(PEG4-NHS ester) is a PEG linker equipped with one DBCO moiety and two PEG4-NHS esters. This compound serves as a versatile tool in click chemistry, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing molecules. It is commonly utilized for protein modification or labeling, making it a valuable reagent in biochemical applications.

Bis-sulfone-PEG4-NHS ester is a bifunctional alkylating labeling reagent that selectively removes cysteine sulfur atoms from native disulfide bonds. These reagents perform bis-alkylation to attach both thiols from two cysteine residues, originating from reduced native disulfide bonds (such as interchain disulfide bonds in antibodies). The reaction results in a covalent bond through a three-carbon bridge, maintaining the protein's structural integrity. The hydrophilic PEG spacer enhances its solubility in aqueous media.