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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7428 | SBI-115 | GPCR19 | |
SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5 | |||
T4083 | BAR501 | BAR 501 | GPCR19 |
BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM). | |||
TQ0252 | BAR502 | FXR , GPCR19 , Autophagy | |
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM). | |||
T4352 | SB756050 | SB-756050,SB 756050 | GPCR19 |
SB756050 is a specific TGR5 agonist. | |||
T8599 | Betazole dihydrochloride | Betazole hydrochloride | Histamine Receptor |
Betazole dihydrochloride (Betazole hydrochloride) is an agonist of H2 receptor. | |||
T11515 | Gut restricted-7 | GR-7 | Potassium Channel |
Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice. | |||
T1824 | TGR5 Receptor Agonist | GPCR19 | |
TGR5 is a potent TGR5(GPCR19) agonist. | |||
T8818 | TC-G 1005 | GPCR19 | |
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available. | |||
TP1740 | GroES mobile loop | ||
GroES mobile loop is a flexible region of unbound GroES that interacts with GroEL via the residues located at the tip of the loop. | |||
T74195 | 4′-Demethylnobiletin | ||
4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment linked to NMDA receptor antagonism th... | |||
T124370 | 5'-Methoxynobiletin | ||
5'-Methoxynobiletin is a useful organic compound for research related to life sciences and the catalog number is T124370. | |||
T32873 | Maralixibat Chloride | SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625 | Potassium Channel |
Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation. | |||
T35371 | Colesevelam Hydrochloride | Others | |
Colesevelam Hydrochloride is a bile acid sequestrant with a higher affinity for glycocholic acid in vitro. Colesevelam Hydrochloride inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduces c... | |||
TP1198 | Sincalide ammonium | SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium | cholecystokinin |
Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secr... | |||
T20689 | Temocaprilat | RNH-5139,RS-5139,RNH 5139,RNH5139,RS5139,RS 5139 | Angiotensin-converting Enzyme (ACE) |
Temocaprilat (RS5139) is an Angiotensin-converting Enzyme (ACE) inhibitor. Temocaprilat is effectively excreted in bile via cMOAT that is deficient in EHBR and that many of other ACE inhibitors have low affinity for cMOA... | |||
T11426 | Gly-β-MCA | FXR | |
Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes. | |||
T14932 | Ceruletide | Cerulein,Caerulein,FI-6934 | cholecystokinin |
Ceruletide (Caerulein) is a potent agonist of cholecystokinin receptor and it also is a safe and effective cholecystokinetic agent. It has a direct spasmogenic effect on the gallbladder muscle and bile ducts. | |||
T15209 | Elobixibat | AZD 7806,A 3309 | Others |
Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation. | |||
T9154 | Sodium taurodeoxycholate hydrate | Taurodeoxycholic acid sodium salt monohydrate | Others |
Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid sodium salt monohydrate) has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. | |||
T64334 | Glycolithocholic acid, sodium salt | Others | |
Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s... | |||
T10623 | BSH-IN-1 | Potassium Channel | |
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B. longum BSH and B. theta BSH). | |||
T7294 | Aramchol | C20-FABAC | Others |
Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholester... | |||
T8752 | BAR 501 impurity | GPCR19 | |
BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act... | |||
T14932L1 | Ceruletide Ammonium Salt | Caerulein Ammonium Salt,Ceruletide Ammonium Salt(17650-98-5 Free base),FI-6934 Ammonium Salt,Cerulein Ammonium Salt | cholecystokinin |
Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs, which is a potent cholecystokinin receptor agonist and a safe and effective cholecystokinin receptor agonist with direct spasmodic e... | |||
T32420 | Kryptogenin | Cryptogenine,Cryptogenin | |
Kryptogenin, derived from carp bile, can be used to synthesize C27-intermediates in bile acid biosynthesis. | |||
T34077 | Piprozoline | piprozolin | |
Prazoline (or prazoline) is a drug used to treat bile. | |||
T30270 | Azidobenzamidotaurocholate | ||
Azido Benzamido Taurocholate is a bile acid transporter. | |||
T37771 | Taurolithocholic Acid 3-sulfate (sodium salt) | ||
Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models... | |||
T34534 | Sarpedobilin | ||
Sarpedobilin is a doubly cyclized bile pigment. It is found in butterflies. | |||
T13622 | Cholestyramine | Colestyramine,Cholestyramine resin | Others |
Cholestyramine (Cholestyramine resin), a bile acid-binding resin, inhibits intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol. | |||
T70688 | S 0960 | ||
S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum. | |||
T69558 | Barixibat | ||
Barixibat is a bile acid transport inhibitor. | |||
T2968L | Hyodeoxycholic acid sodium salt | Sodium hyodeoxycholate,HDCA sodium | |
Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 sy... | |||
T27015 | Cicrotoic acid | ||
Cicrotoic acid, a biochemical drug, acts on bile flow and liquid composition of human bile. | |||
T71790 | WYE-176182 | ||
WYE-176182 is an apical sodium-dependent bile salt transporter (SLC10A2) inhibitor | |||
T34895 | Tocamphyl | Tocanfil,Biliphorin,Gallogen | |
Tocamphyl is a cholagogic agent that stimulates pancreatic exocrine and bile flow when administered in the duodenum. | |||
T28700 | SC-435 mesylate | SC-435,SC435,SC 435 | |
SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol. | |||
T32797 | Lithocholenic acid | ||
Lithocholenic acid is a bile acid that acts as a detergent to solubilize fats for absorption. | |||
T34855 | Thionalide | ||
Thionalide can transport these cpds from liver to bile. | |||
T20928 | Febuprol | H33,K-10033,H 33,H-33,NSC 30151 | |
Febuprol, a choleretic drug, stimulates bile secretion. In addition, it also has lipid-lowering (lowering blood lipid) and spasmolytic (anticonvulsant) properties. | |||
T16818 | S-8921 | Others | |
S-8921 is an inhibitor of ileal Na+/bile acid cotransporter. | |||
T31820 | Fluorescein lisicol | NRL972,NRL-972,NRL 972 | |
Fluorescein lisicol, as an investigational marker of hepatic biliary transporter function, is a fluorescent-labeled bile salt. | |||
T17236 | Volixibat | SHP626,LUM002 | Others |
Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis. | |||
T37178 | Norhyodeoxycholic Acid | ||
Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as... | |||
T21348 | PYR-0503 | ||
PYR-0503 is an intermediate used for chemical synthesis of a number of biologically important molecules, including bile pigments, photosensitizers, porphyrins, anticancer drugs. | |||
T21349 | PYR-8750 | PYR 8750 | |
PYR-8750 is an intermediate used for chemical synthesis of a number of biologically important molecules, including bile pigments, photosensitizers, porphyrins, anticancer drugs. | |||
T37845 | Taurocholic Acid 3-sulfate (sodium salt) | ||
Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligatio... | |||
T10090 | 264W94 | Others | |
264W94 is a robust inhibitor of the ileal bile acid transporter (IBAT) and a novel agent for reducing cholesterol levels. It exhibits CYP7A1 induction and demonstrates significant antilipemic activity. | |||
T16376 | Odevixibat | A4250 | Others |
Odevixibat (A4250) is an effective, selective and orally active ileal bile acid transporter inhibitor. Odevixibat has the potential for the treatment of primary biliary cirrhosis. Odevixibat reduces cholestatic liver and... | |||
T21347 | PYR-9588 | PYR9588 | |
PYR-9588 is an intermediate used for chemical synthesis of a number of biologically important molecules, including bile pigments, photosensitizers, porphyrins, anticancer drugs. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2934 | Bilirubin | Bilibubin,Principal bile pigment,Hematoidin,Hemetoidin | Endogenous Metabolite |
Bilirubin (Principal bile pigment) is a principal pigment of bile and one of the major end products of hemoglobin decomposition. | |||
T5077 | Deoxycholic acid sodium salt | Sodium deoxycholate,Sodium Desoxycholate | Endogenous Metabolite , GPCR19 |
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity. | |||
T19189 | Allocholic acid | Others | |
Allocholic acid is a fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. It is also a potent and specific stimulant of the adult olfactory system. | |||
T8153 | Glycohyodeoxycholic acid | Others , Endogenous Metabolite | |
glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans. | |||
T2965 | Deoxycholic acid | Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic | Endogenous Metabolite , GPCR19 |
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio... | |||
T0700 | Ursodeoxycholic acid | UDCA,Ursodiol | Potassium Channel , Endogenous Metabolite |
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption. | |||
T1285 | Anethole trithione | Anetholtrithion | Others , AChR |
Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia. | |||
T0022 | Taurine | 2-Aminoethanesulfonic acid | LDL , Endogenous Metabolite , Autophagy |
Taurine (2-Aminoethanesulfonic acid), an organic acid, is distributed in various animal tissues. | |||
T29078 | Ursodeoxycholic acid sodium | UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium | FXR , Endogenous Metabolite , GPCR19 |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it... | |||
T31964 | Glycolithocholic acid | Lithocholic acid glycine conjugate,Lithocholylglycine | Others |
Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid. | |||
T2A2481 | Taurochenodeoxycholic Acid | Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine | Apoptosis , TNF , Caspase , Endogenous Metabolite |
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. | |||
T13502 | 3-Oxo-5β-cholanoic acid | Dehydrolithocholic acid | ROR |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)... | |||
T2968 | Hyodeoxycholic acid | NSC 60672,α-Hyodeoxycholic Acid,HDCA | FXR , Endogenous Metabolite , GPCR19 |
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia. | |||
T13522 | 7-Ketolithocholic acid | 3α-Hydroxy-7-oxo-5β-cholanic acid | Endogenous Metabolite |
7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholester... | |||
TN2215 | Taurochenodeoxycholic acid sodium | Sodium taurochenodeoxycholate | Apoptosis , Endogenous Metabolite |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and... | |||
T5714 | 5-O-Demethylnobiletin | 5-DEMETHYLNOBILETIN | Leukotriene Receptor , Lipoxygenase |
5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. | |||
T2834 | Nobiletin | Hexamethoxyflavone | Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy |
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic... | |||
TN1244 | 3'-Demethylnobiletin | LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis | |
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ... | |||
T5234 | Glycoursodeoxycholic acid | Ursodeoxycholylglycine,GUDCA | Others , Endogenous Metabolite |
Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic enviro... | |||
T0516 | Dehydrocholate sodium | Sodium dehydrocholate | Endogenous Metabolite , Lipid |
Dehydrocholate sodium, a hydrocholeretic, can increase bile output to clear increased bile acid load. | |||
T19124 | 3-Oxocholic acid | 3-Ketocholic acid | Endogenous Metabolite |
3-Oxocholic acid(3-Ketocholic acid) is the metabolite of bile acid and the main product of bile degradation by Clostridium perfringens in the intestine.3-Oxocholic acid is a steroid acid mainly found in the bile of mamma... | |||
TJA2398 | Taurodeoxycholic acid sodium hydrate | Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt | Apoptosis , Caspase |
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat. | |||
T7331 | Ursocholic acid | Endogenous Metabolite | |
Ursocholic acid, a bile acid found predominantly in bile of mammals. | |||
T5259 | Glycochenodeoxycholic acid sodium salt | GCDCA,Sodium glycochenodeoxycholate | Apoptosis , Others , Endogenous Metabolite |
Glycochenodeoxycholic acid sodium salt (GCDCA) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environmen... | |||
T5352 | GLYCODEOXYCHOLIC ACID | Others , Endogenous Metabolite | |
Glycodeoxycholic Acid is a bile acid that induces severe pancreatitis in rats. It can induce the apoptosis of SMMC-7721 cells. | |||
T5072 | Glycocholic acid hydrate | Others , Endogenous Metabolite | |
Glycocholic Acid is the product of conjugation of cholic acid with glycine. It is the chief ingredient of the bile of herbivorous animals. | |||
T7628 | 3b-Hydroxy-5-cholenoic acid | Endogenous Metabolite | |
3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin | |||
T14002 | 12-Ketodeoxycholic acid | Endogenous Metabolite | |
12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1]. | |||
T2963 | Cholic Acid | Cholanic acid,Cholate,Colalin | Endogenous Metabolite |
Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion. | |||
T0408 | Dehydrocholic acid | Dehystolin,Felacrinos,Sanocholen,Decholin | Others |
Dehydrocholic acid (Dehystolin) is a synthetic bile acid, produced by the oxidation of cholic acid. | |||
T2831 | Glycocholic acid | Glycocholate,cholylglycine | Others , Endogenous Metabolite |
Glycocholic acid (Glycocholate) is a bile acid with anticancer activity. Glycocholic acid targets against pump resistance-related and non-pump resistance-related pathways. | |||
T4070 | Glycocholic Acid Sodium Salt | Glycocholate Sodium,Sodium Glycocholate | Others |
Glycocholic Acid Sodium Salt (Sodium Glycocholate) is a conjugated bile salt and ionic biologic detergent. It is involved in the emulsification of fats. | |||
T35792 | Isolithocholic Acid | 3-Epilithocholic acid,3β-Hydroxy-5β-cholanic acid,β-Lithocholic acid,isoLCA | Endogenous Metabolite |
Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. | |||
T2532 | Tauroursodeoxycholate | Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA | Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite |
Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode... | |||
TN2349 | Taurodeoxycholate sodium salt | Sodium taurodeoxylate | Endogenous Metabolite |
Taurodeoxycholate sodium salt (Sodium taurodeoxylate) is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. and it inhibits various inflammatory... | |||
T4727 | Taurolithocholic acid sodium salt | Sodium taurolithocholate | Others , Calcium Channel |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors. | |||
T2744 | Methyl Cholate | Cholic acid methyl ester | Others |
Methyl Cholate (Cholic acid methyl ester) is the methyl form of cholic acid. Cholic acid is a major bile acid produced by the liver and synthesized from cholesterol. | |||
T1138 | Taurocholic acid sodium salt hydrate | Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate | Others , Potassium Channel , Endogenous Metabolite |
Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous animals, is used as a detergen... | |||
TN2259 | Taurocholic acid | N-Choloyltaurine | TNF , PI3K |
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathwa... | |||
T4588 | Glycochenodeoxycholic Acid | Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine | Apoptosis , Endogenous Metabolite |
Glycochenodeoxycholic Acid (Lithocholylglycine) is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxycholic acid. Glycolithocholic acid ... | |||
T15245 | Erythromycin estolate | Phtalic anhydride,ilosone | Antibacterial |
T0847 | Chenodeoxycholic acid | CDCA,Chenodiol | Potassium Channel , FXR , Endogenous Metabolite , Autophagy |
Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as ... | |||
T5254 | Glycodeoxycholate Sodium | Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt | Others , Endogenous Metabolite |
Glycodeoxycholate Sodium (Glycodeoxycholic acid sodium salt) induces Apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes ex... | |||
T13506 | 3β-Ursodeoxycholic acid | Isoursodeoxycholic acid | |
3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (administered orally has shown good tolerability and good intestinal absorption. 3β-Ursodeoxycholic acid can undergo enzymatic iso... | |||
TWA2417 | Sodium taurocholate | Taurocholate Sodium | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and... | |||
T2202 | Lithocholic acid | 3α-Hydroxy-5β-cholanic acid | Apoptosis , Others , FXR , Endogenous Metabolite , Autophagy |
Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is... | |||
T0760 | Cholesterol | Cholesterin,Cholesteryl alcohol | Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR |
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us... | |||
T75319 | Taurodeoxycholic acid | Taurodeoxychloic acid | Apoptosis , Calcium Channel , Caspase |
Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic a... | |||
TN6909 | Polyporusterone B | (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one | Others |
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci... | |||
TJO2758 | D-Glucuronic acid | Aldehydo-D-Glucuronic Acid | Others , Endogenous Metabolite |
D-Glucuronic acid (Aldehydo-D-Glucuronic Acid) is a carboxylic acid with structural similarity to glucose with detoxifying activity. The xenobiotic metabolism of various substances such as drugs, pollutants, bilirubin, a... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00529 | FABP6 Protein, Human, Recombinant (His) | Human | E. coli |
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine ... | |||
TMPJ-00207 | AKR1C2 Protein, Human, Recombinant | Human | E. coli |
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation o... | |||
TMPH-00631 | Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His) | E. coli | E. coli |
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. | |||
TMPH-00630 | Heat-labile enterotoxin A chain Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. | |||
TMPH-00632 | Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. | |||
TMPY-02846 | CLPS Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural... | |||
TMPY-00480 | NCAM1 Protein, Human, Recombinant (His) | Human | HEK293 |
NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli... | |||
TMPY-01475 | Jagged 1 Protein, Human, Recombinant (His) | Human | HEK293 |
Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre... | |||
TMPH-02652 | FGF-15 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression. | |||
TMPK-00378 | FGFR4 beta Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors... | |||
TMPK-00379 | FGFR4 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors... | |||
TMPK-01322 | FGFR4 Protein, Rhesus macaque, Recombinant (His) | Rhesus macaque | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors... | |||
TMPH-02681 | GPX7 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. | |||
TMPK-00381 | FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors... | |||
TMPK-00380 | FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors... | |||
TMPY-02249 | FABP6 Protein, Human, Recombinant | Human | E. coli |
Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to t... | |||
TMPH-00721 | YgiS Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the p... | |||
TMPY-00481 | AKR1C4 Protein, Human, Recombinant (His) | Human | E. coli |
Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation ... | |||
TMPY-00084 | CLPS Protein, Rat, Recombinant (His) | Rat | HEK293 |
Colipase belongs to the colipase family. Structural studies of the complex and of colipase alone have revealed the functionality of its architecture. It is a small protein with five conserved disulphide bonds. Structural... | |||
TMPY-03353 | CEL Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activ... | |||
TMPY-03497 | AKR1C2 Protein, Human, Recombinant (His) | Human | E. coli |
AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using ... | |||
TMPY-03874 | NCAM1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli... | |||
TMPY-06789 | NCAM1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli... | |||
TMPY-03857 | MMGT1 Protein, Human, Recombinant (His) | Human | HEK293 |
MMGT1 (Membrane Magnesium Transporter 1, also known as EMC5 and TMEM32) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The encoded protein belongs to the membrane magnesium transport... | |||
TMPY-06786 | NCAM1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli... | |||
TMPY-05590 | NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
NCAM1 (Neural Cell Adhesion Molecule 1, also known as CD56) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. NCAM1 is a neural adhesion protein (NCAM) that belongs to the immunoglobuli... | |||
TMPY-01878 | L-FABP Protein, Human, Recombinant (His) | Human | E. coli |
Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid bindi... | |||
TMPY-03222 | PNLIP Protein, Human, Recombinant (His) | Human | HEK293 |
PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found ... | |||
TMPJ-00715 | FGF-19 Protein, Human, Recombinant (His) | Human | E. coli |
Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis... | |||
TMPY-01587 | SULT2A1 Protein, Human, Recombinant (His) | Human | E. coli |
Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotra... | |||
TMPY-02907 | FGF-19 Protein, Human, Recombinant | Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inclu... | |||
TMPY-01070 | ENPP7 Protein, Human, Recombinant (His) | Human | HEK293 |
Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I memb... | |||
TMPY-02253 | ENPP7 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I memb... | |||
TMPY-02987 | Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal... | |||
TMPY-02706 | Vitamin D Receptor/VDR Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal... | |||
TMPH-01780 | SCP2 Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates d... | |||
TMPH-02959 | Tsukushi Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT... | |||
TMPY-01470 | Jagged 1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre... | |||
TMPY-04813 | ACAT2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e... | |||
TMPH-01044 | CEACAM1 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesi... | |||
TMPH-01045 | CEACAM1 Protein, Human, Recombinant | Human | E. coli |
Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesi... |