bicyclic

GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. It regulates the expression and/or release of insulin and is useful for the metabolic disease research.

Bicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA) with a Ki value of 53 nM.

3-Carene(Delta-3-Carene) is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infiltrates and COX-2 overexpression induced by nociceptive stimuli.3-Carene has anti-injury properties and promotes the activity and expression of alkaline phosphatase, an early marker of osteoblast differentiation.

Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). Citalopram hydrobromide is the orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA).

Camphor (2-Camphanone) is a bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.

Bicyclohexyl is an organic compound with a bicyclic structure, widely used in biochemical experiments and drug synthesis research.

Indole has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. It can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal smell. At very low concentrations, however, it has a flowery smell, and is a constituent of many flower scents (such as orange blossoms) and perfumes.

(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.

Sabinene is a natural product that has antifungal and anti-inflammatory properties

Isobornyl acetate is a natural product derived from the essential oil of the lemongrass plant and is a bicyclic monoterpene. It is used in a variety of applications, including as a flavoring agent, a fragrance ingredient, and a pharmaceutical ingredient.

ALPHA-PINENE ((-)-Alpha-Pinene) is a bicyclic monoterpene found in pine trees and other plants, including Cannabis with diverse biological activities [1]. It reduces the growth of a panel of seven Gram-positive bacteria, seven Gram-negative bacteria, and eight yeast strains with MIC values of 0.75-1.29, 1.05-1.59, and 0.7-1.17%, respectively [2]. It has insecticidal activity against C. molestus larvae with LC50 values ranging from 47 to 49 mg/L.3 ALPHA-PINENE (100 μg/ml) induces apoptosis, increases anion superoxide production and DNA fragmentation, and activates caspase-3 in B16/F10 melanoma cells [4]. In a B16/F10 mouse xenograft model, ALPHA-PINENE(100 ml of a 10 mg/ml solution) reduces the number of metastatic lung nodules by approximately 7-fold. ALPHA-PINENE(8.6 mg/L, aerosol) also increases the time spent in the open arms of the elevated plus maze by approximately 2-fold in mice, indicating anxiolytic-like activity [5].

(±)-Myrtenol is the specific enantiomeric form of the bicyclic monoterpene alcohol known as Myrtenol. (-)-Myrtenol has been demonstrated to possess significant anti-anxiety effects in preclinical behavioral models; additionally, (-)-Myrtenol exhibits characteristics of gastric cell protection, suggesting potential therapeutic applications for gastrointestinal conditions.

Nortropine Hydrochloride is a natural bicyclic alkaloid and a degradation intermediate of tropine, suitable for biochemical experiments and drug synthesis research.

1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.

Phalloidin, a bicyclic heptapeptide found in Gooseberry, is involved in F-actin staining. Phalloidin is a compound that irreversibly polymerizes actin into microfilaments.Phalloidin interferes with cell motility and growth, and can be used to label cerebral blood vessels.

Fmoc-Dap(Boc)-OH, an amino acid derivative featuring an Fmoc protecting group, is utilized in the synthesis of bicyclic peptide tachykinin NK2 antagonists.

4-Iodobutyl benzoate is structurally related to bicyclic heterocyclic compounds such as indole and indoline. It functions as a metabolite of drug amides and is utilized in the treatment of inflammatory bowel disease, degenerative diseases, and intestinal disorders. 4-Iodobutyl benzoate inhibits the activity of proteolytic enzymes by binding to their active sites.

RA VII is used as an antitumor bicyclic hexapeptide of plant origin.

Salinamide A is an effective anti-inflammatory bicyclic depsipeptide.

LY 173013 is a bicyclic pyrazolidinone, it has antibacterial properties.

LY 186826 is an antibacterial agent with bicyclic pyrazolidinone properties.

Valnivudine, a precursor of CF-1743, is an orally effective and highly effective anti-herpes zoster (HZ) nucleoside analogue, a bicyclic nucleoside analogue (BCNA). Valnivudine has antiviral activity and is highly inhibitory against varicella zoster virus (VZV). Valnivudine is rapidly and widely converted into CF-1743 in the body.

Decalin (decahydronaphthalene, also known as bicyclo[4.4.0]decane), a bicyclic organic compound, is an industrial solvent. A colorless liquid with an aromatic odor, it is used as a solvent for many resins or fuel additives. It is the saturated analog of n

Drimane is a bicyclic sesquiterpene. It is the parent structure of many natural products with various biological activity.