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bicuculline

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Bicuculline
d-Bicuculline, (+)-Bicuculline
T2850485-49-4
Bicuculline is an alkaloid extracted from Corydalis decumbens, acting as a competitive antagonist of the neurotransmitter GABAA receptor (IC50 = 2 μM). It also blocks Ca2+-activated potassium (SK) channels and inhibits slow afterhyperpolarization (slow AHP). Bicuculline has anticonvulsant effects and is commonly used to establish mouse seizure models.
  • $38
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Bicuculline methobromide
d-Bicuculline methobromide, (+)-Bicuculline methobromide ; d-Bicuculline methobromide, (+)-Bicuculline methobromide
T7224666016-70-4
Bicuculline methobromide is a selective GABAA receptor antagonist with an IC50 of 3 μM. It can induce clonic-tonic seizures in mammals and block Ca²⁺-activated potassium channels, commonly used to establish models of epilepsy and related neurological disorders.
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8-10 weeks
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Bicuculline methochloride
(-)-Bicuculline methochloride
T7411238641-83-7
Bicuculline methochloride is a competitive GABAA receptor antagonist and allosteric inhibitor with an IC50 of 1.7 μM. It blocks Ca²⁺-dependent activation of potassium channels, exhibits convulsant activity, and is suitable for epilepsy research.
  • $93
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