betulinic acid

Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.

Betulinic acid (Mairin; Gratiolone; Platanol) is a useful organic compound for research related to life sciences and the catalog number is T131503.

Betulinic acid propargyl ester is a pentacyclic lupane triterpene and alkyne derivative of betulinic acid .1,2It has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives.

Betulinic acid derivative-1 demonstrates potent inhibition of osteoclast (OC) differentiation, achieving an IC50 value of 1.86 μM.

Betulinic acid (Standard) is a reference standard for research and analysis in studies involving Betulinic acid. Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.

Betulinic acid 3β-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranoside is a natural saponin suitable for biochemical experiments and drug synthesis research.

Betulinic acid methyl ester is a natural product exhibiting growth-inhibitory effects against mouse B16 2F2 melanoma cells (IC50=4.9 μM).

Betulinic acid palmitate is a natural product for research related to life sciences. The catalog number is TN5987 and the CAS number is 19833-15-9.

Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin.

Dihydrobetulinic acid is a bioactive chemical.

23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.

23-Hydroxybetulinic acid (Standard) is a reference standard for research and analysis in studies involving 23-Hydroxybetulinic acid. 23-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.

Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues. Also used in the preparation of HIV-1 inhibitors derived from Betulinic Acid (B330250).

Betulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is found in birch sap as well.

NVX-207 is a derivative of betulinic acid. It has anti-cancer activity.

RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly more potent than Betulinic acid (EC50= 1.04 μM). It exhibits much higher selectivity for TGR5 over FXRα. The compound enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. Additionally, RG-239 inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 cells and microglia. RG-239 is applicable for research related to type 2 diabetes.

Lup-20(29)-en-28-oic-3-O-beta-glucopyranosyl(2-1)-O-beta-glucopyranoside is a betulinic acid glycoside from Schefflera venulosa.

2,3-Indolobetulinic glycine amide is a pentacyclic triterpene and derivative of betulinic acid .1It has been used in the synthesis of betulinic acid derivatives with anticancer activity. 1.Kumar, V., Rani, N., Aggarwal, P., et al.Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivativesBioorg. Med. Chem. Lett.18(18)5058-5062(2008)

N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)

Taraxerol acetate exhibits significant antiviral activity against herpes simplex virus type II, while exerting comparatively weaker effects on cell cycle arrest and apoptosis in AGS gastric cancer cells than taraxerol. Taraxerol acetate is a bioactive triterpene constituent of Anoectochilus roxburghiana, where its contribution to the plant’s antidiabetic activity is mechanistically associated with protein tyrosine phosphatase 1B (PTP1B) inhibition alongside betulin and betulinic acid, highlighting its relevance for antiviral, metabolic disease, and natural product pharmacology research.

RPR103611, a derivative of betulinic acid, serves as an effective inhibitor of HIV-1 entry, exhibiting IC50 values of 80, 0.27, and 0.17 for CCR5-tropic virus YU2, CXCR4-tropic virus NL4-3, and dual-tropic virus 89.6, respectively [1].

RORγ antagonist 1 (compound 22), a potent derivative of betulinic acid, acts as an antagonist to RORγ with a dissociation constant (K D) of 0.18 μM. It demonstrates anti-proliferative effects in the HPAF-II pancreatic cancer xenograft model, inhibits the RAS/MAPK and AKT/mTORC1 signaling pathways, and triggers caspase-dependent apoptosis in pancreatic cancer cells [1].

Betulinic glycine amide, a pentacyclic triterpenoid derivative of betulinic acid, serves as a precursor for synthesizing derivatives with anticancer and antiviral activity.

Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine