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Cat No. | Product Name | Synonyms | Targets |
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T22782 | FGIN-1-27 | Others | |
high affinity agonist of the translocator protein | |||
T2625 | MK-0752 | Beta Amyloid , Gamma-secretase | |
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM). | |||
T8548 | Metoprine | Histone Methyltransferase , Antifolate , Histamine Receptor | |
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. | |||
T2009 | SB-3CT | MMP | |
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM). | |||
T19438 | Myristyl nicotinate | Tetradecyl nicotinate | GPR |
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer. | |||
T8778 | TTK21 | Epigenetic Reader Domain | |
TTK21 is an activator of CBP/p300 histone acetyltransferase activity. | |||
T15108 | DG-041 | Prostaglandin Receptor | |
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per... | |||
T1993 | J-147 | J147 | Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase |
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... | |||
T3119 | JNJ-63533054 | JNJ 63533054 | GPR |
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. | |||
T10760 | Ceramides Mixture | Telomerase | |
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activ... | |||
T24055 | FAUC 213 | FAUC213,FAUC-213 | Dopamine Receptor |
FAUC 213 is a selective full antagonist of the dopamine D4 receptor. | |||
T2684 | JNJ-1661010 | JNJ1661010,Takeda-25,JNJ 1661010 | FAAH |
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2. | |||
T9687 | MAGL-IN-4 | His121 ARG57 | Lipase |
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases. | |||
T8526 | Metformin | 1,1-Dimethylbiguanide | Mitophagy , AMPK , Autophagy |
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm... | |||
T11861 | LM11A-31 dihydrochloride | Others | |
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni... | |||
T1065 | Baclofen | Lioresal | GABA Receptor |
Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp... | |||
T0082 | Domperidone | R33812 | Dopamine Receptor |
Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger z... | |||
T12877L | Seltorexant | JNJ-42847922 | OX Receptor |
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... | |||
T21935L | AMN082 free base | AMN082 | GluR |
AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist. | |||
T2316 | Omarigliptin | MK-3102 | Proteasome , DPP-4 |
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. | |||
T23394 | SR 57227A | SR 57227 hydrochloride | 5-HT Receptor |
SR 57227A (SR 57227 hydrochloride) is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 rece... | |||
T12492 | Pivagabine | CXB-722 | GABA Receptor |
Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor... | |||
T13664 | DSP-4 hydrochloride | Neurotoxin DSP 4 (hydrochloride) | Others |
DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) (Neurotoxin DSP 4 hydrochloride) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus... | |||
T2141 | Mecamylamine hydrochloride | Inversine,Mevasin | AChR |
Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension. | |||
T21422 | Methylnaltrexone bromide | Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 | Opioid Receptor |
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... | |||
T7601L | Carbetocin acetate | Carbetocin acetate(37025-55-1 free base) | Oxytocin Receptor |
Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth. | |||
T8630 | Baclofen hydrochloride | 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride | GABA Receptor |
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe... | |||
T20570 | Labetalol | Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne | Adrenergic Receptor |
Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... | |||
T6438 | Cefoselis Sulfate | FK 037 Sulfate,FK-037 | Antibacterial , Antibiotic |
Cefoselis Sulfate is a widely used beta-lactam antibiotic. | |||
T11571 | HLY78 | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine | Wnt/beta-catenin |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. | |||
T1667 | Tandutinib | MLN518,CT53518,NSC726292 | Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit |
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu... | |||
T0740 | Metformin hydrochloride | Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride | Mitophagy , AMPK , Autophagy |
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro... | |||
T0825 | Ebselen | SPI-1005,PZ-51,CCG-39161 | Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease |
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... | |||
T7601 | Carbetocin | Oxytocin Receptor | |
Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth. | |||
T21935 | AMN082 | AMN 082 dihydrochloride | GluR |
AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. | |||
T12017 | Methyllycaconitine citrate | MLA | AChR |
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier. | |||
T6845 | GNE-317 | GNE317 | PI3K , mTOR |
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB). | |||
T38013 | Sonlicromanol hydrochloride | ||
Sonlicromanol hydrochloride (KH176), a derivative of Trolox, is a ROS-redox modulator that effectively crosses the blood-brain barrier. It is specifically employed in the investigation of mitochondrial disorders[1]. | |||
TQ0026 | MDR-1339 | DWK-1339 | Beta Amyloid , Gamma-secretase |
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. | |||
T17211 | Vafidemstat | ORY-2001 | Histone Demethylase , MAO |
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases. | |||
T1612 | Neostigmine methyl sulfate | Normastigmin,Hodostin,Syntostigmin | AChR , AChE |
Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis. | |||
T5518 | N-acetylcysteine amide | Reactive Oxygen Species , ROS | |
N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that can permeate cell membranes and the blood-brain barrier. | |||
T33467 | MOMIPP | PI3K | |
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2]. | |||
T35559 | SAG 21k | Hedgehog/Smoothened | |
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration. | |||
T10855 | CO23 | Thyroid hormone receptor(THR) | |
CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development. | |||
T2708 | SL327 | SL 327,SL-327 | MEK , DNA/RNA Synthesis |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. | |||
T9070 | ASP2905 | ASP-2905 | Potassium Channel |
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities | |||
T7340 | 5'-N-Ethylcarboxamidoadenosine | NECA | Adenosine Receptor |
5'-N-Ethylcarboxamidoadenosine (NECA) is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation. | |||
T10335 | Antihistamine-1 | P450 | |
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM). | |||
T6705 | TIC10 Isomer | ONC201 isomer,TIC10 Analogue | Others |
TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0795 | Rutin | Quercetin 3-O-rutinoside,Rutoside | Beta Amyloid , Prostaglandin Receptor , Autophagy |
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties. | |||
T0130 | Physostigmine Salicylate | AChR , AChE | |
Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean. | |||
T0848 | L-DOPA | Levodopa,3,4-Dihydroxyphenylalanine | Dopamine Receptor , Endogenous Metabolite |
L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai... | |||
T22417 | Rutin hydrate | Rutoside,Sophorin,Quercetin-3-O-rutinoside | Beta Amyloid , Others , Autophagy |
Rutin hydrate (Sophorin), a kind of glycoside, widely exists in many plants including citrus fruit. | |||
TN6774 | Emodin 6-O-β-D-glucoside | Glucoemodin | Others |
Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ... | |||
T0700 | Ursodeoxycholic acid | UDCA,Ursodiol | Potassium Channel , Endogenous Metabolite |
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption. | |||
T29078 | Ursodeoxycholic acid sodium | UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium | FXR , Endogenous Metabolite , GPCR19 |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it... | |||
T4917 | Dehydroascorbic acid | (L)-Dehydroascorbic acid | Endogenous Metabolite |
L-Dehydro Ascorbic Acid is the reversibly oxidized form of ascorbic acid;Dehydroascorbic acid ((L)-Dehydroascorbic acid), a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experi... | |||
T6S0444 | Salvianolic acid A | Dan Phenolic Acid A | MMP |
Salvianolic acid A (Dan Phenolic Acid A) could protect the blood brain barrier through inhibition of matrix metallopeptidase 9 (MMP-9) and anti-inflammation. | |||
T6S0119 | Dauricine | Apoptosis , Others , NF-κB | |
1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro... | |||
T67710 | 3-Indoleacrylic acid | Endogenous Metabolite | |
3-Indoleacrylic acid is a metabolite of tryptophan produced by Peptostreptococcus species. 3-Indoleacrylic acid has a beneficial effect on intestinal epithelial barrier function and mitigates inflammatory responses by im... | |||
TN1236 | 3',4',7-Trihydroxyisoflavone | MAPK , JNK | |
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radical scavenging properties.3',4',7-Trihydroxyisoflavone enhan... | |||
T0883 | Tramiprosate | Homotaurine,3-Amino-1-propanesulfonic acid,Alzhemed | Beta Amyloid , GABA Receptor |
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GAB... | |||
T3851 | Vicenin 2 | Vicenin -2 | RAAS |
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective,... | |||
T6S0721 | Orientin | Lutexin,Luteolin-8-glucoside | Others |
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int... | |||
T3893 | Forsythoside B | TNF , NF-κB | |
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
T5S1632 | Barlerin | 8-O-Acetylshanzhiside methyl ester,ND01 | VEGFR , TNF , NF-κB , Akt , Caspase |
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e... | |||
T4S0797 | Berberine | Berberin,Umbellatine | Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy |
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3.... | |||
T4439 | Sn-Glycero-3-phosphocholine | Choline Alfoscerate,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC | Endogenous Metabolite , AChE |
sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment o... | |||
T13493 | 3-Acetyldeoxynivalenol | Others | |
3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin. | |||
T14114 | Acivicin | AT-125,U-42126 | Others |
Acivicin (AT-125) is a γ-glutamyl transpeptidase (GGT) inhibitor derived from the Streptomyces sviceus natural product. It possesses anti-cancer and anti-parasitic properties and can effectively cross the blood-brain bar... | |||
TN1793 | Isorhamnetin 3-O-galactoside | Cacticin | ERK , TNF , NF-κB |
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic for treatment of severe vascular inflammatory diseases. | |||
T13680 | Enniatin B1 | ERK | |
Enniatin B1, a Fusarium mycotoxin, crosses the blood-brain barrier, decreases the activation of ERK (p44/p42), and inhibits moderately TNF-α-induced NF-κB activation. Furthermore, it inhibits acyl-CoA: cholesterol acyltr... | |||
T61171 | Cyclo(his-pro) TFA | ||
Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone, has shown inhibitory effects on NF-κB nuclear accumulation. Additionally, it possesses the ability to cross the... | |||
TN1913 | Marmin | Calcium Channel , Antifection , Histamine Receptor | |
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous... | |||
T77207 | Acivicin hydrochloride | ||
Acivicin hydrochloride (AT-125 hydrochloride), derived from Streptomyces sviceus, functions as a γ-glutamyl transpeptidase (GGT) inhibitor. This compound possesses the ability to cross the blood-brain barrier and demonst... | |||
T75571 | Withaphysalin D | ||
Withaphysalin D, isolated from water lilies, is a selective antagonist for the N-methyl-D-aspartate receptor (NMDAR) containing GluN2B with neuroprotective properties. This compound is capable of crossing the blood-brain... | |||
TN5228 | Vestitol | Antifection | |
Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from... | |||
TN3364 | Agrimonolide | Apoptosis , Dehydrogenase , p38 MAPK , ROS , JAK | |
Agrimonolide, a compound derived from isocoumarins and found mainly in the herb Agrimonia pilosa Ledeb, has significant biological activity. agrimonolide exerts anti-inflammatory effects by inhibiting lipopolysaccharide ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00162 | IL-1 alpha/IL-1A Protein, Human, Recombinant (hFc) | Human | Human Cells |
Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately ... | |||
TMPY-01776 | Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) | Human | HEK293 |
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and... | |||
TMPY-01725 | Leptin Receptor Protein, Human, Recombinant (His) | Human | HEK293 |
Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe... | |||
TMPY-01938 | CD98 Protein, Human, Recombinant (His) | Human | HEK293 |
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr... | |||
TMPY-02358 | CD98 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr... | |||
TMPH-02504 | DEFA5 Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. | |||
TMPH-01576 | KRT16 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. | |||
TMPH-02503 | DEFA1 Protein, Mouse, Recombinant (GST & His) | Mouse | E. coli |
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium. | |||
TMPH-01706 | Mucin-16/MUC16 Protein, Human, Recombinant (His) | Human | HEK293 |
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. | |||
TMPK-00509 | E-Cadherin/Cadherin-1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelia... | |||
TMPK-00990 | GUCY2C Protein, Mouse, Recombinant (His & Avi) | Mouse | HEK293 |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio... | |||
TMPH-00760 | Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His) | Neocosmosporum cucurbitae | Yeast |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infe... | |||
TMPK-01279 | GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His) | Cynomolgus | HEK293 |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio... | |||
TMPH-00761 | Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant | Neocosmosporum cucurbitae | E. coli |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infe... | |||
TMPK-00661 | IL-22 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab... | |||
TMPK-01194 | IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | E. coli |
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab... | |||
TMPH-01751 | Nephrin/NPHS1 Protein, Human, Recombinant (His) | Human | E. coli |
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role ... | |||
TMPY-03175 | Claudin-11 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solut... | |||
TMPH-01577 | KRT18 Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT... | |||
TMPH-00031 | Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc) | Aeromonas sobria | E. coli |
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by trans... | |||
TMPK-00856 | GUCY2C Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio... | |||
TMPK-01388 | GUCY2C Protein, Canine, Recombinant (aa 21-430, His) | Canine | HEK293 |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio... | |||
TMPK-00991 | GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier functio... | |||
TMPH-03756 | Wint7b Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d... | |||
TMPH-01708 | Mucin-2/MUC2 Protein, Human, Recombinant (His) | Human | E. coli |
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constitu... | |||
TMPH-01578 | KRT18 Protein, Human, Recombinant (His) | Human | HEK293 |
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT... | |||
TMPH-02861 | Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO) | Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d... | |||
TMPH-01607 | LCE3A Protein, Human, Recombinant (His) | Human | E. coli |
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and G... | |||
TMPH-02122 | SLC2A1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most imp... | |||
TMPK-01153 | PLVAP Protein, Human, Recombinant (His) | Human | HEK293 |
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such... | |||
TMPY-00375 | VMO1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from... | |||
TMPK-00163 | IL-33 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are exp... | |||
TMPK-01365 | CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated | Human | HEK293 |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy.Thought to provide a protecti... | |||
TMPK-01137 | FAM3D Protein, Human, Recombinant (hFc) | Human | HEK293 |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (m... | |||
TMPK-01366 | CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated | Human | HEK293 |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy.Thought to provide a protecti... | |||
TMPK-01359 | CA125/MUC16 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy.Thought to provide a protecti... | |||
TMPY-04780 | VMO1 Protein, Human, Recombinant | Human | HEK293 |
Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from... | |||
TMPK-01158 | Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulat... | |||
TMPK-01394 | CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) | Human | HEK293 |
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy.Thought to provide a protecti... | |||
TMPK-00710 | Claudin-4 Protein-VLP, Human, Recombinant | Human | HEK293 |
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been asso... | |||
TMPH-01575 | KRT10 Protein, Human, Recombinant (His) | Human | E. coli |
Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nas... | |||
TMPJ-01456 | Mucin-17/MUC17 Protein, Human, Recombinant (His) | Human | Human Cells |
Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was m... | |||
TMPH-03753 | MYLK Protein, Human, Recombinant (His) | Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos... | |||
TMPH-01604 | SLC7A5 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptop... | |||
TMPH-02965 | Uromodulin/Umod Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play ... | |||
TMPY-06965 | Claudin-6 Protein, Human, Recombinant (GFP & His) | Human | HEK293 |
Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeabi... | |||
TMPJ-00161 | IL-1 alpha/IL-1A Protein, Human, Recombinant (Avi), Biotinylated | Human | E. coli |
Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately ... | |||
TMPY-06805 | Claudin-6 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 |
Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeabi... | |||
TMPH-00838 | LAMB1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix co... | |||
TMPY-01690 | Carboxylesterase 2/CES2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and... | |||
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Cat No. | Product Name | ||
---|---|---|---|
L5900 | CNS-Penetrant Compound Library | 516 compounds | |
A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L3900 | DNA Damage & Repair Compound Library | 937 compounds | |
A unique collection of 937 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L3980 | DNA Damage and Repair Compound Library Plus | 667 compounds | |
Well-chosen 667 compounds with unique structures targeting DNA damage & repair; | |||
L7500 | Coagulation and Anticoagulation Compound Library | 154 compounds | |
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L2540 | Gut Microbial Metabolite Library | 614 compounds | |
A unique collection of 614 gut microbial metabolites which can be used for HTS and HCS; |