avenanthramide a

Avenanthramide A is a naturally occurring, orally active plant defensin that binds to and inhibits RNA helicase DDX3, induces mitochondrial swelling and CRC cell apoptosis, increases ROS production, exhibits antitumor activity, and can be used in colorectal cancer research.

Avenanthramide A-d4 is the deuterium-labeled form of Avenanthramide A. This compound is a plant defensin found in oats (Avena sativa L.). It targets the RNA helicase DDX3, leading to mitochondrial swelling, increased ROS production, and induction of apoptosis in CRC cells. In mouse models, Avenanthramide A has demonstrated antitumor activity and exhibits oral bioavailability.

Avenanthramide E is a biochemical.

Avenanthramide-C methyl ester inhibits NF-κB activation by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM), thereby dose-dependently inhibiting the expression and secretion of IL-6, IL-8, and MCP-1 in human aortic endothelial cells.

Avenanthramide D is a phenylamide-type natural product derived from oats, composed of a hydroxycinnamic acid derivative and an anthramide structure. Avenanthramide D exhibits biological activities such as antioxidant and anti-inflammatory effects, and can inhibit the transient receptor potential cation channel subfamily A member 1 (TRPA1) (IC₅₀ = 43 µM), exerting its effects by modulating inflammation-related signaling pathways.

Avenanthramide C is an orally available natural alkaloid with antioxidant/inflammatory properties that reduces the expression of TNF-a, BAK, IL-1b, and Bcl-2; reverses memory and behavioral deficits in Alzheimer's disease, with a reduction in caspase-3 cleavage and an increase in levels of pS9GSK-3β and IL-10, is able to bind α1A adrenergic and stimulate AMPK; can attenuate noise and drug-induced hearing loss.

Avenanthramide B is a natural product that can be used in related research in the field of life sciences. Its product number is TN8487.