arp2/3 complex

Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).

Cytochalasin F reversibly inhibits cytokinesis and possesses various biological activities including the inhibition of macrophage endocytosis and exocytosis.

Cytochalasin G exhibits reversible inhibition of cytokinesis and also inhibits macrophage phagocytosis and exocytosis, among other biological activities.

Cytochalasin L possesses reversible biological activities, including the inhibition of cytoplasmic division, as well as the suppression of both endocytosis and exocytosis in phagocytic macrophages.

Cytochalasin M exhibits various biological activities, including reversible inhibition of cytoplasmic division and the suppression of both endocytosis and exocytosis in macrophages.

Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.