arabidopsis

Glucosinalbate is a natural product isolated from Arabidopsis thaliana.

Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.

PHYD protein, Arabidopsis belongs to the phytochrome apoprotein family in Arabidopsis.

Endosidin 7, a specific inhibitor of callose synthase, organizes callose deposition during plant cytoplasmic division without affecting endosomal transport during interphase or cytoskeletal organization, preventing late cytokinesis.

Thermospermine is a structural isomer of spermine that plays a role in inhibiting xylem differentiation and can enhance the translation of SAC51 and SACL1 in Arabidopsis thaliana. Thermospermine is also used in studies as a plant growth regulator and for controlling wood biomass production.

ES9-17, an analog of ES9 (endosidin9), is an inhibitor of clathrin-mediated endocytosis (CME). ES9-17 inhibits the uptake of FM4-64 and transferrin. ES9-17 inhibits root growth of Arabidopsis seedings.

16-hydroxy Hexadecanoic Acid (Juniperic acid) is a compound isolated from the leaves and stems of Arabidopsis thaliana and can be used to prevent, alleviate, or treat metabolic diseases.

Diniconazole (Rac-diniconazole) is a fungicide. It is known as a plant hormone abscisic acid (ABA) catabolic inhibitor, and acts as a potent competitive inhibitor of recombinant Arabidopsis ABA 8'-hydroxylase, CYP707A3.

7-Methoxy-1-naphthaleneacetic acid is an inhibitor of auxin action in plants. 7-Methoxy-1-naphthaleneacetic acid inhibits polar auxin transport and tropic responses associated with asymmetric auxin distribution in Arabidopsis and maize. 7-Methoxy-1-naphthaleneacetic acid inhibits auxin transport mediated by AUX1, PIN, and ABCB proteins expressed in yeast.

N(delta)-acetylornithine is a non-protein amino acid and a defence-related plant metabolite, primarily found in Arabidopsis. The inclusion of N(delta)-acetylornithine in feed can reduce the reproduction of Myzus persicae and exhibits certain toxic properties.

Camalexin, a phytoalexin isolated from (Camelina sativa), exhibits antifungal, antibacterial, antiproliferative, and anticancer activities, and can induce ROS production.

DL-m-Tyrosine is a non-proteinogenic amino acid. It inhibits microbial proliferation and spore formation, and significantly suppresses root development of lettuce, Arabidopsis thaliana and other plants. Combined with carbidopa, it exerts significant antihypertensive pharmacological activity and can be used as a research tool in the development and mechanism exploration of biopesticides.

Jarin-1, a jasmonic acid-amido synthetase (JAR1) inhibitor (IC50: 3.8 μM), specifically suppresses bioactive JA biosynthesis in Arabidopsis and other plants.

Vitamin U chloride is a compound with antioxidant, anti-ulcer, and orally available properties that inhibits adipocyte differentiation and promotes skin wound healing, suitable for gastrointestinal ulcers.

SL agonist 1, a Strigolactone (SL) agonist, is effective in promoting Arabidopsis seed germination through its recognition by the SL receptors OmKAI2d3 and OmKAI2d4.

D-Psicose (D-Allulose) is an orally active rare sugar. It effectively inhibits p38-MAPK phosphorylation and MCP-1 expression, while blocking the AGEs/RAGE/NF-kappaB signaling pathway. D-Psicose demonstrates significant bioactivity in research involving pancreatic beta-islet protection, hyperglycemia improvement, lipid metabolism regulation, and the mitigation of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).

KK181N1 is a triazolide selective inhibitor of the karrikin (KAR) receptor KAI2 that binds non-covalently to the catalytic pocket of KAI2 and has no significant effect on the related receptor AtD14. KK181N1 selectively inhibits KAR-induced phenotypes in Arabidopsis.

AtHPPD-IN-1 (Compound III-15) is an HPPD inhibitor and herbicide with high safety for peanuts. It has an IC50 of 12 nM against Arabidopsis HPPD.

Desmeninol is an α-hydroxy analogue of methionine, which is widely used as feed additive for livestock and poultry, and used for balanced protein metabolism management of patients with renal insufficiency.

DHAD-IN-1 (Compound I-6e) is a potent inhibitor of dihydroxy acid dehydratase (DHAD), exhibiting a Ki value of 1 μM against Arabidopsis thaliana DHAD. It demonstrates 100% efficacy in controlling weeds such as oats and foxtail. DHAD-IN-1 is a promising candidate for herbicide research.

Iptriazopyrid (NC-656) is a triazole carboxamide herbicide that targets 4-hydroxyphenylpyruvate dioxygenase (HPPD). It exhibits a Ki value of 24.3 nM for Arabidopsis HPPD and 33.3 nM for rice HPPD. By inhibiting the synthesis of plastoquinone and carotenoids, Iptriazopyrid causes weed yellowing and death. It shows promise in research for controlling paddy field weeds such as barnyard grass.

HPPD/PPO-IN-1 (Compound B14) functions as a dual inhibitor of both HPPD and PPO, exhibiting IC50 values of 0.12 μM for Arabidopsis thaliana HPPD and 0.51 μM for Nicotiana tabacum PPO. This compound demonstrates broad-spectrum herbicidal activity while being safe for use on peanut and cotton crops. HPPD/PPO-IN-1 is suitable for the development of environmentally friendly herbicides.

Methiozolin is an oxazoline herbicide designed for selectively controlling annual bluegrass in turfgrass. At low concentrations, it strongly inhibits the biosynthesis of cellulose and hemicellulose in maize root cells. Methiozolin also inhibits recombinant Arabidopsis tyrosine aminotransferase, with an IC50 of approximately 200 µM. In addition to effectively controlling vegetative growth, methiozolin significantly inhibits inflorescence formation, aiding in seed bank reduction.

Flusulfinam is an HPPD inhibitor and herbicide (Herbicide) with an IC50 of 0.0181 μM for Arabidopsis thaliana HPPD. It inhibits the catalytic activity of recombinant Arabidopsis thaliana HPPD and demonstrates strong herbicidal activity against barnyard grass (Echinochloa crus-galli). Additionally, Flusulfinam suppresses the growth of crabgrass (Digitaria sanguinalis).