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Search Result

Search Results for " androgen "

Targets

Androgen Receptor Others

200

Compounds

36

Natural Products

40

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T10320 Androgen receptor antagonist 1 Others
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP...
T60988 Androgen receptor antagonist 4
Androgen receptor antagonist 4 (Compound AT2) has anticancer activities. Androgen receptor antagonist 4 potently antagonizes the activity of AR transcriptional, inhibits downstream target gene of AR, and blocks the DHT-i...
T80633 Androgen receptor degrader-1 Androgen Receptor
Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].
T60987 Androgen receptor antagonist 3
Androgen receptor antagonist 3 (Compound C18) has anticancer activities that is an antagonist of androgen receptor (AR) (IC 50 = 2.4 μM) [1].
T80647 Androgen receptor degrader-2 Androgen Receptor
Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].
T79024 Androgen receptor-IN-5 Androgen Receptor
Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties. It additionally suppresses the synthesis of IL-17A, IL-17F, and INF-γ.
T83119 Androgen receptor antagonist 9 Androgen Receptor
Androgen Receptor Antagonist 9 (compound 28) serves as an antagonist to the androgen receptor [1].
T63324 Androgen receptor antagonist 5
Androgen receptor antagonist 5 is a potent antagonist of the androgen receptor (AR) (IC50: 6.17 μM). Androgen receptor antagonist 5 inhibited the proliferation of prostate cancer cells LNCaP and showed antitumor effect i...
T79891 Androgen receptor degrader-3 Androgen Receptor
Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential applications in prostate cancer research [1].
T72985 Masofaniten Androgen receptor-IN-2
Masofaniten (Androgen receptor-IN-2), a potent, orally active inhibitor of the androgen receptor, demonstrates significant antitumor activity against prostate cancer.
T0380 Bicalutamide ICI-176334 Androgen Receptor , Autophagy
Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
T9035 Testosterone undecanoate Others , Androgen Receptor
Testosterone undecanoate is a metabolite of Testosterone, which is a promising androgen for male hormonal contraception.
T22263 Bavdegalutamide ARV-110 Androgen Receptor
Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR). Bavdegalutamide can be used in studies about prostate cancer. Bavdegalutamide shows oral activity and selectivity and facilitates the ubiquitinati...
T12928 SK33 Androgen Receptor
SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.
T9246 JNJ-63576253 Androgen Receptor
JNJ-63576253 is a Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
T6829 EPI-001 EPI001,EPI 001 Apoptosis , Androgen Receptor , PPAR
EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.
T14116 ACP-105 Androgen Receptor
ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.
T13272 UT-155 Androgen Receptor
UT-155 is a selective and potent antagonist of the androgen receptor (AR) (Ki: 267 nM for UT-155 binding to AR-LBD).
T12323 ORM-15341 Androgen Receptor
ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)
T7690 2-hydroxy Flutamide Androgen Receptor
2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
T26539 AC-262536 AC262536 Androgen Receptor
AC-262536 is a selective androgen receptor (SAR) modulator. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone.
T3618 GSK-2881078 GSK2881078,GSK 2881078 Androgen Receptor
GSK-2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function.
T20625 Prochloraz Sporgon,Prelude Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and...
T2339 Apalutamide ARN-509 Androgen Receptor , GABA Receptor
Apalutamide (ARN-509) is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
T5100 DJ-V-159 DJ-V159 GPR , Androgen Receptor
DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).
T8217 Enzalutamide carboxylic acid Androgen Receptor , Drug Metabolite
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
T21740 RD162 Androgen Receptor
RD162 is a non-steroidal antiandrogen (NSAA) specifically binding to the androgen receptor (AR).
T8933 JNJ-63576253 free base TRC253,JNJ-63576253 Androgen Receptor
JNJ-63576253 free base (TRC253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the re...
T0489 Flutamide SCH 13521 Androgen Receptor
Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
T39695 ARD-2128 Androgen Receptor
ARD-2128 is a highly potent, orally bioavailable PROTAC (proteolysis-targeting chimera) degrader of the androgen receptor (AR), effectively diminishing AR protein levels, suppressing AR-regulated gene expression in tumor...
T6889 MI-136 Apoptosis , Epigenetic Reader Domain , Androgen Receptor
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T13273 UT-34 Androgen Receptor
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...
T6002 Enzalutamide MDV3100 Androgen Receptor , Autophagy
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP). Enzalutamide activates autophagy, has antitumor activity, and is commonly used in the treatment of desmoplasia-resistant prostate canc...
T6400 AZD3514 Androgen Receptor
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
T6915 Darolutamide ODM-201,BAY-1841788 Androgen Receptor
Darolutamide (BAY-1841788) is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
T0272 Nilutamide RU23908 Androgen Receptor
Nilutamide (RU23908), an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors, but not for estrogen, progesto...
T0476 Spironolactone SC9420,Abbolactone Glucocorticoid Receptor , Androgen Receptor , Autophagy
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T2556 Nandrolone decanoate 19-Nortestosterone decanoate Others , HIV Protease
Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enter...
T12146 N-Desmethyl-Apalutamide N-Desmethyl Apalutamide P450 , Androgen Receptor
N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.
T7358 YK11 Androgen Receptor
YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.
T9179 CLP-3094 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE Androgen Receptor
CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP...
T1167 Cyproterone acetate Androcur,Cyproterone 17-O-acetate Androgen Receptor
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ...
T7440 P,p'-DDE p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene Androgen Receptor , Drug Metabolite
p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT
T20789 S-23 (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23 Androgen Receptor
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal ve...
T2236 RU 58841 RU58841,PSK-3841,HMR-3841 Androgen Receptor
RU 58841 (PSK-3841) is a specific androgen receptor antagonist or anti-androgen; RU 58841(PSK-3841) has a significant effect on hair regrowth.
T19450 N-desmethyl Enzalutamide N-desmethyl MDV 3100 Androgen Receptor
N-desmethyl Enzalutamide (N-desmethyl MDV 3100) is the active Enzalutamide metabolite.It is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar p...
T3357 Clascoterone Cortexolone 17 alpha-propionate,17 alpha-propionate,CB-03-01,Cortexolone 17α-propionate Androgen Receptor
Clascoterone (CB-03-01) is a new topical and peripherally selective androgen antagonist.
T6509 Galeterone VN-124-1,TOK-001,VN/124-1,VN 124 P450 , Androgen Receptor
Galeterone (VN 124) is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an a...
T16090 MK-0773 PF-05314882 Androgen Receptor
MK-0773 (PF-05314882) is a selective androgen receptor modulator that binds to AR (IC50: 6.6 nM) for the study of diseases caused by endocrine abnormalities.
T10359 AR antagonist 1 Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.

Compounds

Androgen receptor antagonist 1
T10320
Synonym:
Target: Others
Androgen receptor antagonist 4
T60988
Synonym:
Target:
Androgen receptor degrader-1
T80633
Synonym:
Target: Androgen Receptor
Androgen receptor antagonist 3
T60987
Synonym:
Target:
Androgen receptor degrader-2
T80647
Synonym:
Target: Androgen Receptor
Androgen receptor-IN-5
T79024
Synonym:
Target: Androgen Receptor
Androgen receptor antagonist 9
T83119
Synonym:
Target: Androgen Receptor
Androgen receptor antagonist 5
T63324
Synonym:
Target:
Androgen receptor degrader-3
T79891
Synonym:
Target: Androgen Receptor
Masofaniten
T72985
Synonym: Androgen receptor-IN-2
Target:
Bicalutamide
T0380
Synonym: ICI-176334
Target: Androgen Receptor, Autophagy
Testosterone undecanoate
T9035
Synonym:
Target: Others, Androgen Receptor
Bavdegalutamide
T22263
Synonym: ARV-110
Target: Androgen Receptor
SK33
T12928
Synonym:
Target: Androgen Receptor
JNJ-63576253
T9246
Synonym:
Target: Androgen Receptor
EPI-001
T6829
Synonym: EPI001,EPI 001
Target: Apoptosis, Androgen Receptor, PPAR
ACP-105
T14116
Synonym:
Target: Androgen Receptor
UT-155
T13272
Synonym:
Target: Androgen Receptor
ORM-15341
T12323
Synonym:
Target: Androgen Receptor
2-hydroxy Flutamide
T7690
Synonym:
Target: Androgen Receptor
AC-262536
T26539
Synonym: AC262536
Target: Androgen Receptor
GSK-2881078
T3618
Synonym: GSK2881078,GSK 2881078
Target: Androgen Receptor
Prochloraz
T20625
Synonym: Sporgon,Prelude
Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal
Apalutamide
T2339
Synonym: ARN-509
Target: Androgen Receptor, GABA Receptor
DJ-V-159
T5100
Synonym: DJ-V159
Target: GPR, Androgen Receptor
Enzalutamide carboxylic acid
T8217
Synonym:
Target: Androgen Receptor, Drug Metabolite
RD162
T21740
Synonym:
Target: Androgen Receptor
JNJ-63576253 free base
T8933
Synonym: TRC253,JNJ-63576253
Target: Androgen Receptor
Flutamide
T0489
Synonym: SCH 13521
Target: Androgen Receptor
ARD-2128
T39695
Synonym:
Target: Androgen Receptor
MI-136
T6889
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, Androgen Receptor
UT-34
T13273
Synonym:
Target: Androgen Receptor
Enzalutamide
T6002
Synonym: MDV3100
Target: Androgen Receptor, Autophagy
AZD3514
T6400
Synonym:
Target: Androgen Receptor
Darolutamide
T6915
Synonym: ODM-201,BAY-1841788
Target: Androgen Receptor
Nilutamide
T0272
Synonym: RU23908
Target: Androgen Receptor
Spironolactone
T0476
Synonym: SC9420,Abbolactone
Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy
Nandrolone decanoate
T2556
Synonym: 19-Nortestosterone decanoate
Target: Others, HIV Protease
N-Desmethyl-Apalutamide
T12146
Synonym: N-Desmethyl Apalutamide
Target: P450, Androgen Receptor
YK11
T7358
Synonym:
Target: Androgen Receptor
CLP-3094
T9179
Synonym: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE
Target: Androgen Receptor
Cyproterone acetate
T1167
Synonym: Androcur,Cyproterone 17-O-acetate
Target: Androgen Receptor
p,p'-DDE
T7440
Synonym: p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene
Target: Androgen Receptor, Drug Metabolite
S-23
T20789
Synonym: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23
Target: Androgen Receptor
RU 58841
T2236
Synonym: RU58841,PSK-3841,HMR-3841
Target: Androgen Receptor
N-desmethyl Enzalutamide
T19450
Synonym: N-desmethyl MDV 3100
Target: Androgen Receptor
Clascoterone
T3357
Synonym: Cortexolone 17 alpha-propionate,17 alpha-propionate,CB-03-01,Cortexolone 17α-propionate
Target: Androgen Receptor
Galeterone
T6509
Synonym: VN-124-1,TOK-001,VN/124-1,VN 124
Target: P450, Androgen Receptor
MK-0773
T16090
Synonym: PF-05314882
Target: Androgen Receptor
AR antagonist 1
T10359
Synonym:
Target: Androgen Receptor, Ligand for E3 Ligase, Ligands for Target Protein for PROTAC
1 2 3 4
Cat No. Product Name Synonyms Targets
T14008 2,2,5,7,8-Pentamethyl-6-Chromanol PMC Androgen Receptor
2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol), which has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines.
T8117 Metenolone acetate Methenolone acetate Others , Androgen Receptor
Metenolone acetate (Methenolone acetate) is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.
T19470 Nandrolone propionate Others , Androgen Receptor
Nandrolone propionate is an anabolic steroid action primarily consisting of androgenic and nitrogen-retentive properties.
TQ0209 Ailanthone Δ13-Dehydrochaparrinone Androgen Receptor
Ailanthone (Δ13-Dehydrochaparrinone) is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 309 nM).
T3393 Triptophenolide Hypolide,(+)-Triptophenolide Androgen Receptor
Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.
T8709 Nandrolone phenylpropionate Nandrolone phenpropionate Androgen Receptor
Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis
TQ0214 Dimethylcurcumin ASC-J9,GO-Y025 Androgen Receptor
Dimethylcurcumin (ASC-J9) (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.
TC0025 Testosterone acetate NSC523836,NSC-523836,NSC 523836 Others
Testosterone acetate (NSC-523836) is a hormone with in vitro antitumor activity.
T2991 3,3'-Diindolylmethane HB 236,DIM,Arundine Androgen Receptor , Autophagy
3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.
T2895 Lupeol Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol Apoptosis , Androgen Receptor , Akt
Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.
T2207 Adrenosterone 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G Androgen Receptor , Endogenous Metabolite
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
T1261 Medroxyprogesterone Acetate Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate) Glucocorticoid Receptor , Estrogen/progestogen Receptor , Progesterone Receptor , Androgen Receptor , Endogenous Metabolite
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been...
T0856 Dehydroisoandrosterone 3-acetate Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate Androgen Receptor
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.
TC0026 Testosterone benzoate Others
Testosterone benzoate is a synthetic, injected anabolic androgenic steroid (AAS) and an androgen ester specifically
T7873 Iberverin Others
Iberverin is a naturan product. It induces phase II enzyme activity and decreases expression of androgen receptors in prostate cancer cells.
T13518 5α-Pregnane-3β,6α-diol-20-one Others
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, capable of being synthesized by androgen-responsive prostate cancer cells under conditions of starvation.
TN5031 Sitostenone Others
Sitostenone has antioxidation activity. Stigmasta-4-en-3-one(Sitostenone) can be used for the treatment of androgen-dependent diseases, especially for the treatment of benign prostatic hyperplasia.
T9171 Methenolone enanthate Others
Methenolone enanthate is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of anemia due to bone marrow failure.
TN1805 Isosilybin B Apoptosis , Androgen Receptor
Isosilybin B is a flavonolignan extracted from silymarin that exhibits anti-prostate cancer (PCA) activity, inhibits cancer cell proliferation, and contributes to G1-phase blockade and apoptosis.Isosilybin B induces degr...
TN1677 Gartanin BCL , Caspase , JNK
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...
T5574 Guggulsterone Guggulsterone E&Z Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T3390 Obacunone Apoptosis , Aromatase , p38 MAPK
Obacunone has cytotoxicity in androgen-dependent human prostate Y cells. Obacunone exerts an antivirulence effect on S. Typhimurium and may serve as a lead compound for development of antivirulence strategies for S. Typh...
T3851 Vicenin 2 Vicenin -2 RAAS
Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective,...
T4000 (±)-Equol Equol,(R,S)-Equol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Drug Metabolite
(±)-Equol ((R,S)-Equol) is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occu...
TN1150 Procyanidin B3 Histone Acetyltransferase
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1308 6-Hydroxyflavanone Others , Lipoxygenase , COX , GABA Receptor
6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A r...
T6491 (-)-(S)-Equol (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) is an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective a...
TN3416 Angelol M Others
Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
T75702 Galloylalbiflorin
Galloylalbiflorin (6′-O-Galloylalbiflorin), an androgen receptor (AR) antagonist with an IC50 value of 53.3 μM, is a compound isolated from the roots of Paeonia lactiflora. It exhibits anti-androgen activity [1].
TN5878 7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
TN6638 (E)-6-O-(p-coumaroyl)scandoside methyl ester
(E)-6-O-(p-coumaroyl)scandoside methyl ester shows moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells.
T73780 11β-Hydroxyandrosterone
11β-Hydroxyandrosterone, an 11-oxygenated androgen metabolite, is derived from 11β-hydroxyandrostenedione [1] [2].
TN4774 Physalin A ERK , BCL , p38 MAPK , NF-κB , Androgen Receptor , ROS , JAK , JNK , STAT , p53 , Autophagy
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and dow...
T11834 Leelamine hydrochloride Others
Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabin...
TN6337 Lupichromone 5,7-Dihydroxy-6,8-diprenylchromone
Eriosemation significant androgen receptor (AR) inhibition activity, suggests that it could be a promising candidate for further evaluation for prostate cancer prevention or management.
TN1061 Ganoderol B Androgen Receptor
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy throu...

Natural Products

2,2,5,7,8-Pentamethyl-6-Chromanol
T14008
Synonym: PMC
Target: Androgen Receptor
Metenolone acetate
T8117
Synonym: Methenolone acetate
Target: Others, Androgen Receptor
Nandrolone propionate
T19470
Synonym:
Target: Others, Androgen Receptor
Ailanthone
TQ0209
Synonym: Δ13-Dehydrochaparrinone
Target: Androgen Receptor
Triptophenolide
T3393
Synonym: Hypolide,(+)-Triptophenolide
Target: Androgen Receptor
Nandrolone phenylpropionate
T8709
Synonym: Nandrolone phenpropionate
Target: Androgen Receptor
Dimethylcurcumin
TQ0214
Synonym: ASC-J9,GO-Y025
Target: Androgen Receptor
Testosterone acetate
TC0025
Synonym: NSC523836,NSC-523836,NSC 523836
Target: Others
3,3'-Diindolylmethane
T2991
Synonym: HB 236,DIM,Arundine
Target: Androgen Receptor, Autophagy
Lupeol
T2895
Synonym: Fagarasterol,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol
Target: Apoptosis, Androgen Receptor, Akt
Adrenosterone
T2207
Synonym: 11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G
Target: Androgen Receptor, Endogenous Metabolite
Medroxyprogesterone Acetate
T1261
Synonym: Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,Farlutin,Medroxyprogesterone (acetate)
Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, Endogenous Metabolite
Dehydroisoandrosterone 3-acetate
T0856
Synonym: Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,androstenolone acetate
Target: Androgen Receptor
Testosterone benzoate
TC0026
Synonym:
Target: Others
Iberverin
T7873
Synonym:
Target: Others
5α-Pregnane-3β,6α-diol-20-one
T13518
Synonym:
Target: Others
Sitostenone
TN5031
Synonym:
Target: Others
Methenolone enanthate
T9171
Synonym:
Target: Others
Isosilybin B
TN1805
Synonym:
Target: Apoptosis, Androgen Receptor
Gartanin
TN1677
Synonym:
Target: BCL, Caspase, JNK
Guggulsterone
T5574
Synonym: Guggulsterone E&Z
Target: Apoptosis, FXR, Akt, Caspase, JNK, Autophagy
Obacunone
T3390
Synonym:
Target: Apoptosis, Aromatase, p38 MAPK
Vicenin 2
T3851
Synonym: Vicenin -2
Target: RAAS
(±)-Equol
T4000
Synonym: Equol,(R,S)-Equol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite
Procyanidin B3
TN1150
Synonym:
Target: Histone Acetyltransferase
6-Hydroxyflavanone
TN1308
Synonym:
Target: Others, Lipoxygenase, COX, GABA Receptor
(-)-(S)-Equol
T6491
Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol
Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite
Angelol M
TN3416
Synonym:
Target: Others
Galloylalbiflorin
T75702
Synonym:
Target:
7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
TN5878
Synonym:
Target:
(E)-6-O-(p-coumaroyl)scandoside methyl ester
TN6638
Synonym:
Target:
11β-Hydroxyandrosterone
T73780
Synonym:
Target:
Physalin A
TN4774
Synonym:
Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy
Leelamine hydrochloride
T11834
Synonym:
Target: Others
Lupichromone
TN6337
Synonym: 5,7-Dihydroxy-6,8-diprenylchromone
Target:
Ganoderol B
TN1061
Synonym:
Target: Androgen Receptor

Recombinant Proteins

Species：
Human (32)
Mouse (7)
Canine (1)
Expression System：
E. coli (18)
HEK293 (17)
Baculovirus-Insect Cells (3)
in vitro E. coli expression system (2)
Tag：
His (12)
Tag Free (6)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (5)
N-terminal 6xHis-tagged (3)
His,GST (2)
His (1)
C-His (1)
C-terminal mFc-tagged (1)
GST (1)
His,AVI (1)
Cat No. Product Name Species Expression System
TMPY-06986 FGF-8b Protein, Human, Recombinant Human E. coli
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-00005 FGF-8a Protein, Human, Recombinant Human E. coli
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPH-00932 Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPY-00133 PARM-1 Protein, Human, Recombinant (His) Human HEK293
PARM-1 Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 25.7 kDa. Accession number: AAH13294.1
TMPY-03807 SMR3B Protein, Human, Recombinant (His) Human HEK293
SMR3B Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 7.3 kDa. Accession number: P02814
TMPY-01116 SMR3B Protein, Human, Recombinant (mFc) Human HEK293
SMR3B Protein, Human, Recombinant (mFc) is expressed in HEK293 with mFc tag. The predicted molecular weight is 32.2 kDa. Accession number: P02814
TMPH-00933 ADTRP Protein, Human, Recombinant (His & Myc) Human in vitro E. coli expression system
ADTRP Protein, Human, Recombinant (His & Myc) is expressed in in vitro E. coli expression system.
TMPY-00908 Renin Protein, Human, Recombinant (His) Human HEK293
Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sod...
TMPH-02284 USP26 Protein, Human, Recombinant (His) Human E. coli
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPY-06352 ALDH1A3 Protein, Mouse, Recombinant (His) Mouse E. coli
Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potent...
TMPY-01899 ALDH1A3 Protein, Human, Recombinant (His) Human E. coli
Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potent...
TMPY-00611 UBE2B Protein, Mouse, Recombinant Mouse E. coli
The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i...
TMPH-02139 CYP17A1 Protein, Human, Recombinant (GST) Human E. coli
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy...
TMPY-03259 Calreticulin Protein, Human, Recombinant (His) Human HEK293
Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering...
TMPJ-00207 AKR1C2 Protein, Human, Recombinant Human E. coli
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation o...
TMPK-01387 EPhA3 Protein, Canine, Recombinant (His) Canine HEK293
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude...
TMPH-01303 HSD17B11 Protein, Human, Recombinant (His & Myc) Human E. coli
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate stero...
TMPY-03258 Calreticulin Protein, Human, Recombinant (hFc) Human HEK293
Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering...
TMPY-06327 Calreticulin Protein, Human, Recombinant Human HEK293
Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering...
TMPK-00850 MFGE8 Protein, Mouse, Recombinant (His) Mouse HEK293
MFGE8 (Milk Fat Globule EGF And Factor V/VIII Domain Containing) is a Protein Coding gene. Diseases associated with MFGE8 include Anal Paget's Disease and Topographical Agnosia. Among its related pathways are Activated P...
TMPY-03056 LSD1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 ...
TMPY-04408 CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in pro...
TMPY-06655 PSCA Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse HEK293
Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Knockdown of PSCA induced EMT and reduced met...
TMPH-00851 HSD3B1 Protein, Human, Recombinant (His & Myc) Human E. coli
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the...
TMPY-06710 PSCA Protein, Mouse, Recombinant (His) Mouse HEK293
Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Knockdown of PSCA induced EMT and reduced met...
TMPY-02844 EBP1 Protein, Human, Recombinant (His) Human E. coli
EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-riboso...
TMPY-05808 Renin Protein, Human, Recombinant (R66K, His) Human HEK293
Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sod...
TMPY-01231 Renin Protein, Mouse, Recombinant (His) Mouse HEK293
Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sod...
TMPH-01900 DDX5 Protein, Human, Recombinant (His & Myc) Human E. coli
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop r...
TMPH-02235 TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) Human in vitro E. coli expression system
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02238 TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated Human E. coli
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02236 TMPRSS2 Protein, Human, Recombinant (E. coli, His) Human E. coli
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPY-01846 Activin A Protein, Mouse, Recombinant (His) Mouse HEK293
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two ...
TMPY-02216 S100P Protein, Human, Recombinant Human E. coli
Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P / S100E contains twoEF-hand domains. S100P protein...
TMPY-02043 PARK7/DJ-1 Protein, Human, Recombinant (His) Human E. coli
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress....
TMPY-01190 INHBB Protein, Human, Recombinant (His) Human HEK293
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two ...
TMPY-04944 S100P Protein, Human, Recombinant, Biotinylated Human E. coli
Protein S100-P, also known as Protein S100-E, S100 calcium-binding protein P, S100P and S100E, is a nucleus and cytoplasm protein that belongs to the S-100 family. S100P / S100E contains twoEF-hand domains. S100P protein...
TMPY-04484 ACK1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell mig...
TMPH-02237 TMPRSS2 Protein, Human, Recombinant (His & Myc) Human HEK293
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-01616 LRP2 Protein, Human, Recombinant (mFc) Human HEK293
Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the...
FGF-8b Protein, Human, Recombinant
TMPY-06986
Species: Human
Expression System: E. coli
FGF-8a Protein, Human, Recombinant
TMPY-00005
Species: Human
Expression System: E. coli
Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)
TMPH-00932
Species: Human
Expression System: E. coli
PARM-1 Protein, Human, Recombinant (His)
TMPY-00133
Species: Human
Expression System: HEK293
SMR3B Protein, Human, Recombinant (His)
TMPY-03807
Species: Human
Expression System: HEK293
SMR3B Protein, Human, Recombinant (mFc)
TMPY-01116
Species: Human
Expression System: HEK293
ADTRP Protein, Human, Recombinant (His & Myc)
TMPH-00933
Species: Human
Expression System: in vitro E. coli expression system
Renin Protein, Human, Recombinant (His)
TMPY-00908
Species: Human
Expression System: HEK293
USP26 Protein, Human, Recombinant (His)
TMPH-02284
Species: Human
Expression System: E. coli
ALDH1A3 Protein, Mouse, Recombinant (His)
TMPY-06352
Species: Mouse
Expression System: E. coli
ALDH1A3 Protein, Human, Recombinant (His)
TMPY-01899
Species: Human
Expression System: E. coli
UBE2B Protein, Mouse, Recombinant
TMPY-00611
Species: Mouse
Expression System: E. coli
CYP17A1 Protein, Human, Recombinant (GST)
TMPH-02139
Species: Human
Expression System: E. coli
Calreticulin Protein, Human, Recombinant (His)
TMPY-03259
Species: Human
Expression System: HEK293
AKR1C2 Protein, Human, Recombinant
TMPJ-00207
Species: Human
Expression System: E. coli
EPhA3 Protein, Canine, Recombinant (His)
TMPK-01387
Species: Canine
Expression System: HEK293
HSD17B11 Protein, Human, Recombinant (His & Myc)
TMPH-01303
Species: Human
Expression System: E. coli
Calreticulin Protein, Human, Recombinant (hFc)
TMPY-03258
Species: Human
Expression System: HEK293
Calreticulin Protein, Human, Recombinant
TMPY-06327
Species: Human
Expression System: HEK293
MFGE8 Protein, Mouse, Recombinant (His)
TMPK-00850
Species: Mouse
Expression System: HEK293
LSD1 Protein, Human, Recombinant (His & GST)
TMPY-03056
Species: Human
Expression System: Baculovirus-Insect Cells
CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)
TMPY-04408
Species: Human
Expression System: Baculovirus-Insect Cells
PSCA Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPY-06655
Species: Mouse
Expression System: HEK293
HSD3B1 Protein, Human, Recombinant (His & Myc)
TMPH-00851
Species: Human
Expression System: E. coli
PSCA Protein, Mouse, Recombinant (His)
TMPY-06710
Species: Mouse
Expression System: HEK293
EBP1 Protein, Human, Recombinant (His)
TMPY-02844
Species: Human
Expression System: E. coli
Renin Protein, Human, Recombinant (R66K, His)
TMPY-05808
Species: Human
Expression System: HEK293
Renin Protein, Mouse, Recombinant (His)
TMPY-01231
Species: Mouse
Expression System: HEK293
DDX5 Protein, Human, Recombinant (His & Myc)
TMPH-01900
Species: Human
Expression System: E. coli
TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)
TMPH-02235
Species: Human
Expression System: in vitro E. coli expression system
TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated
TMPH-02238
Species: Human
Expression System: E. coli
TMPRSS2 Protein, Human, Recombinant (E. coli, His)
TMPH-02236
Species: Human
Expression System: E. coli
Activin A Protein, Mouse, Recombinant (His)
TMPY-01846
Species: Mouse
Expression System: HEK293
S100P Protein, Human, Recombinant
TMPY-02216
Species: Human
Expression System: E. coli
PARK7/DJ-1 Protein, Human, Recombinant (His)
TMPY-02043
Species: Human
Expression System: E. coli
INHBB Protein, Human, Recombinant (His)
TMPY-01190
Species: Human
Expression System: HEK293
S100P Protein, Human, Recombinant, Biotinylated
TMPY-04944
Species: Human
Expression System: E. coli
ACK1 Protein, Human, Recombinant (GST)
TMPY-04484
Species: Human
Expression System: Baculovirus-Insect Cells
TMPRSS2 Protein, Human, Recombinant (His & Myc)
TMPH-02237
Species: Human
Expression System: HEK293
LRP2 Protein, Human, Recombinant (mFc)
TMPH-01616
Species: Human
Expression System: HEK293
Cat No. Product Name
L2195 Anti-Prostate Cancer Compound Library

2096 compounds
2096 compounds associated with prostate cancer that can be used for high-throughput and high-content screening.

Libraries

Anti-Prostate Cancer Compound Library
L2195
Compounds: 2096
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