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Search Result

Search Results for " analgesia "

Targets

Adrenergic Receptor

36

Compounds

4

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2524 Dexmedetomidine Adrenergic Receptor
Dexmedetomidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. The physiologic effect of dexmedetomidine is by means of General Anesthesia.
T6554 JZL 184 JZL184 Lipase
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
T6579 Medetomidine hydrochloride MPV785,Medetomidine HCl,Domitor Adrenergic Receptor
Medetomidine hydrochloride (MPV785) is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
T21422 Methylnaltrexone bromide Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 Opioid Receptor
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af...
T6466 Dexmedetomidine hydrochloride Precedex,(+)-Medetomidine hydrochloride,(S)-Medetomidine hydrochloride,Dexmedetomidine HCl Adrenergic Receptor
Dexmedetomidine hydrochloride (Precedex) is an imidazole derivative that is an agonist of the adrenergic alpha-2 receptor. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.
T1780 Parecoxib SC 69124,Vorth-P,Valus-P COX
Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.
T20172L Kyotorphin acetate Endogenous Metabolite , Antibacterial
Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.
T50082 Org 25543 Chloride channel
Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.
T6504 Flupirtine maleate Katadolon maleate Potassium Channel , NMDAR , iGluR
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.
T0056 Oxeladin citrate Others
Oxeladin citrate is a highly potent and effective cough suppressant, which can treat all types of cough of various etiologies. It is not related to opium or its derivatives, so treatment with oxeladin is no risk of add...
T1787 Levobupivacaine Sodium Channel
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...
T31541 D-Kyotorphin H-L-Tyr-D-Arg-OH
D-Kyotorphin is a synthetic neuropeptide kyotorphin analog that produces naloxone reversible analgesia.
T34152L Propiomazine HCl Propiomazine hydrochloride,Largon
Propiomazine HCl is an analgesia adjunct.
T27888 LY 190388 LY190388,LY-190388
LY 190388 is a penicillamine-containing enkephalin analog used as an mu receptor agonist with analgesia activity.
T70078 Fadolmidine
Fadolmidine is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia.
T25675 Leucinal L-Leucinal
Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.
T32105 Cipepofol HSK3486,HSK 3486,HSK-3486
HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects.
T12970L Solabegron HCl GW-427,353,GW427353,GW-427353,GW 427,353,GW427,353
Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells.
T31190 Dafphedyn
Dafphedyn, [D-Ala2, (F5) Phe4]-dynorphin 1-13-NH2 (DAFPHEDYN) is an effective analog of strong endorphin 1-13 and produces diuretic and deep analgesia when administered intravenously in rats.
T68959 Fenobam hydrate
Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits ba...
T80518 Mambalgin-3 Sodium Channel
Mambalgin-3, an acid-sensitive ion channel 1 (ASIC1) inhibitor, has potential applications in analgesia research [1].
T76186 Tyr-W-MIF-1
Tyr-W-MIF-1, an opioid tetrapeptide, exhibits both opiate and antiopiate activities, and has been demonstrated to induce analgesia [1] [2] [5].
T28845 SR142948A HCl SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride
SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It...
T11038 Dibutyryl-cGMP sodium Bt2cGMP sodium Others
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in ...
TP1958 PL-017 PL 017
Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hypert...
T80515 β-Endorphin (1-27) (human) Opioid Receptor
β-Endorphin (1-27) (human) is an opioid antagonist that selectively binds to μ-, δ-, and κ-opioid receptors, with dissociation constants (Kis) of 5.31, 6.17, and 39.82 nM, respectively. It inhibits analgesia induced by b...
T75840 Hemokinin 1, human TFA
Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] ...
T37670 CAY10568
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, w...
T75919 PL-017 TFA
PL-017 TFA, a potent and selective μ-opioid receptor agonist, displays significant affinity with an IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ-site. This compound is effective in producing long-lasting, reversibl...
T81763 MOR agonist-3
MOR agonist-3 (Compound 84) is a dual D3R/MOR antagonist with K i values of 382 nM and 55.2 nM, respectively. It shows promise for analgesia via partial agonism at MORs and may mitigate opioid abuse via D3R antagonism. T...
T61475 Ropivacaine mesylate
Ropivacaine mesylate, a long-acting amide local anaesthetic, is used for spinal block and effectively mitigates neuropathic pain. It achieves analgesia by reversibly inhibiting sodium ion influx in nerve fibers, thus blo...
T37374 URB754
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mo...
T70077 Fadolmidine HCl
Fadolmidine, also known as MPV-2426, is a novel and potent alpha2 -adrenoceptor (alpha2) -AR) agonist developed for spinal analgesia. Fadolmidine displayed high affinity and full agonist efficacy at all three human alpha...
T73677 SR 142948 dihydrochloride
SR 142948 dihydrochloride is a selective, orally active, non-peptide neurotensin receptor (NT) antagonist, featuring IC50 values of 1.19 nM, 0.32 nM, and 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, res...
T37391 PSEM 308 hydrochloride
PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neuro...
T36722 Deltorphin II (trifluoroacetate salt)
Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [3...

Compounds

Dexmedetomidine
T2524
Synonym:
Target: Adrenergic Receptor
JZL 184
T6554
Synonym: JZL184
Target: Lipase
Medetomidine hydrochloride
T6579
Synonym: MPV785,Medetomidine HCl,Domitor
Target: Adrenergic Receptor
Methylnaltrexone bromide
T21422
Synonym: Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728
Target: Opioid Receptor
Dexmedetomidine hydrochloride
T6466
Synonym: Precedex,(+)-Medetomidine hydrochloride,(S)-Medetomidine hydrochloride,Dexmedetomidine HCl
Target: Adrenergic Receptor
Parecoxib
T1780
Synonym: SC 69124,Vorth-P,Valus-P
Target: COX
Kyotorphin acetate
T20172L
Synonym:
Target: Endogenous Metabolite, Antibacterial
Org 25543
T50082
Synonym:
Target: Chloride channel
Flupirtine maleate
T6504
Synonym: Katadolon maleate
Target: Potassium Channel, NMDAR, iGluR
Oxeladin citrate
T0056
Synonym:
Target: Others
Levobupivacaine
T1787
Synonym:
Target: Sodium Channel
D-Kyotorphin
T31541
Synonym: H-L-Tyr-D-Arg-OH
Target:
Propiomazine HCl
T34152L
Synonym: Propiomazine hydrochloride,Largon
Target:
LY 190388
T27888
Synonym: LY190388,LY-190388
Target:
Fadolmidine
T70078
Synonym:
Target:
Leucinal
T25675
Synonym: L-Leucinal
Target:
Cipepofol
T32105
Synonym: HSK3486,HSK 3486,HSK-3486
Target:
Solabegron HCl
T12970L
Synonym: GW-427,353,GW427353,GW-427353,GW 427,353,GW427,353
Target:
Dafphedyn
T31190
Synonym:
Target:
Fenobam hydrate
T68959
Synonym:
Target:
Mambalgin-3
T80518
Synonym:
Target: Sodium Channel
Tyr-W-MIF-1
T76186
Synonym:
Target:
SR142948A HCl
T28845
Synonym: SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride
Target:
Dibutyryl-cGMP sodium
T11038
Synonym: Bt2cGMP sodium
Target: Others
PL-017
TP1958
Synonym: PL 017
Target:
β-Endorphin (1-27) (human)
T80515
Synonym:
Target: Opioid Receptor
Hemokinin 1, human TFA
T75840
Synonym:
Target:
CAY10568
T37670
Synonym:
Target:
PL-017 TFA
T75919
Synonym:
Target:
MOR agonist-3
T81763
Synonym:
Target:
Ropivacaine mesylate
T61475
Synonym:
Target:
URB754
T37374
Synonym:
Target:
Fadolmidine HCl
T70077
Synonym:
Target:
SR 142948 dihydrochloride
T73677
Synonym:
Target:
PSEM 308 hydrochloride
T37391
Synonym:
Target:
Deltorphin II (trifluoroacetate salt)
T36722
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T5691 Paulownin Anti-infection
Paulownin, a furofuran lignan from Paulownia tomentosa,has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity.
T5734 (+)-BORNEOL d-Borneol GABA Receptor
(+)-BORNEOL (d-Borneol) is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM.
T3834 8-Epideoxyloganic acid ROS , Immunology/Inflammation related
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibl...
TN3778 De-4'-O-methylyangambin Antifection
De-4'-O-methylyangambin exhibits antibacterial effects. It also has analgesia activity.

Natural Products

paulownin
T5691
Synonym:
Target: Anti-infection
(+)-BORNEOL
T5734
Synonym: d-Borneol
Target: GABA Receptor
8-Epideoxyloganic acid
T3834
Synonym:
Target: ROS, Immunology/Inflammation related
De-4'-O-methylyangambin
TN3778
Synonym:
Target: Antifection

Recombinant Proteins

Species：
Androctonus mauritanicus (1)
Expression System：
Baculovirus (1)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPH-00055 Alpha-toxin Amm8  Protein, Androctonus mauritanicus, Recombinant (His & Myc) Androctonus mauritanicus Baculovirus
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The toxin principally slows the inactivation proc...
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