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Results for "

aldh2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    11
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
  • Antibody Products
    1
    TargetMol | Antibody_Products
ALDH2 modulator 1
T678321629615-99-1In house
ALDH2 modulator 1 is a potent, orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
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8-10weeks
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TargetMol | Inhibitor Sale
Dyclonine hydrochloride
Dyclonine HCl, Dyclocaine hydrochloride
T1389536-43-6
Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .
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RV01
T127811016897-10-1
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduces iNOS expression and has anti-neuroinflammatory effects. rV01 reduces tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion. RV01 reduced tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) mRNA levels and secretion, inhibited lps-induced ROS production and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, decreased toll-like receptor 4 (TLR4) protein expression, and inhibited lps-induced activation of mitogen-activated protein kinase (MAPK) and nuclear transcription factor-кB (NF-кB) signaling pathways.
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6-8 weeks
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TargetMol | Inhibitor Sale
4-Hydroxynonenal
4-HNE
T1014875899-68-2
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
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NCT-505
T121962231079-74-4
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with IC50 values of >57 μM, 22.8 μM, 20.1 μM, and >57 μM, respectively.
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CVT-10216
T150221005334-57-5
CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (IC50: 1.3 μM). CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.
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Aldi-2
T204275499997-25-0
Aldi-2 is a potent and specific covalent inhibitor of aldehyde dehydrogenases (ALDHs), with IC50 values of 2.5 μM for ALDH1A1, 6.4 μM for ALDH2, and 1.9 μM for ALDH3A1. This compound is applicable in cancer research.
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10-14 weeks
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Alda-1
Alda 1
T2662349438-38-6
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
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TargetMol | Inhibitor Sale
NCT 501 hydrochloride
T41159
NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.
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KS106
T630812408477-50-7
KS106 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activity, inhibits ALDH1A1, ALDH2, and ALDH3A1 with IC50 of 334, 2137, and 360 nM, respectively.KS106 contributes to apoptosis, induces an increase in G2 M cell cycle arrest, and can be used to study melanoma and colon cancer.
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6-8 weeks
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KS100
T639922408477-54-1
KS100 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activities.KS100 inhibits ALDH1A1, ALDH2 and ALDH3A1 with IC50 of 334, 2137 and 360 nM, respectively.KS100 promotes apoptosis and induces cell-cycle arrest, which can be used to study colon cancer.
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7-10 days
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