aging

IDRA-21 is a positive AMPA receptor modulator.

Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.

Anti-aging agent 1 (compound 24), a piperlongumine (PL) derivative, demonstrates a significant enhancement in senolytic activity, being 50 times more effective against senescent WI-38 fibroblasts than PL [1].

Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.

Torin 1 is an effective inhibitor of mTORC1 2 with (IC50: 2 nM 10 nM); has 1000-fold selectivity for mTOR than PI3K.

SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM) and is associated with aging-related diseases.

AGN-201904 is an omeprazole prodrug and proton pump inhibitor, which may delay aging and be used for the prevention and treatment of peptic ulcers.

Folic acid (Vitamin B9) is a vitamin B9 that is essential for the synthesis of DNA RNA and for the production and maintenance of new cells. Folic acid deficiency can lead to anemia, neural tube closure defects, tumors, aging, and other diseases.

D-Galactose (Alpha-D-galactose) is an aldohexose that exists naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.

Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a C-glycoside, a xylose derivative, that stimulates the production of glycosaminoglycans (GAGs) and heparan sulfate proteoglycans (HSPGs) and induces a higher deposition of proteins in basement membranes and dermal-epidermal junctions (DEJs). Pro-xylane is used to maintain skin elasticity and improve skin aging.

J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.

Lycopene (ψ,ψ-Carotene) is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. As a class, carotenoids are pigment compounds found in photosynthetic organisms (plants, algae, and some types of fungus), and are chemically characterized by a large polyene chain containing 35-40 carbon atoms; some carotenoid polyene chains are terminated by two 6-carbon rings. In animals, carotenoids such as lycopene may possess antioxidant properties which may retard aging and many degenerative diseases. As an essential nutrient, lycopene is required in the animal diet.

Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects.

L-Cystine (Cystine Acid) is not considered one of the 20 amino acids, L-Cystine (Cystine Acid) is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains. It functions as an antioxidant and protects tissues against radiation and pollution, slowing the aging process. It also aids protein synthesis. L-Cystine (Cystine Acid) is abundant in many proteins of skeletal tissues and skin, and found in insulin and digestive enzymes chromotrypsinogen A, papain, and trypsinogen.

Protocatechualdehyde (3,4-Dihydroxybenzaldehyde), a natural polyphenol compound derived from radix Salviae Miltiorrhizae roots, exhibits diverse biological activities and finds extensive medicinal applications as an antioxidant, anti-aging, antibacterial, and anti-inflammatory agent.

Cyclic N-Acetyl-D-mannosamine is a monosaccharide used as a precursor in the chemical or enzymatic synthesis of neuraminic acid found in glycolipids and glycoproteins.N-Acetyl-D-mannosamine is a specific substrate for the synthesis of n -acetylneuraminic acid, an essential precursor for bacterial podoplanar polysialic acid (PA).N-Acetyl-D-mannosamine is used in the synthesis of sialic acid. mannosamine is used in the synthesis of sialic acid. It is also an intermediate in the synthesis of many carbohydrate-derived bioactive compound families and drug candidates.N-Acetyl-D-mannosamine is used in the study of cognitive disorders and aging.

L-Carnosine (Karnozin) is is an antioxidant naturally found in skeletal muscle, brain tissue. It has the potential to suppress many of the biochemical changes that accompany aging.

Hydroxypinacolone Retinoate (HPR) is a retinoid commonly added to skin care products and can be used to study skin aging and acne.

N-Isopropyl-N-Phenyl-1,4-Phenylenediamin is a rubber anti-aging agent

1.(-)-Fucose (6-Desoxygalactose) can anti-infective, anti-cancer, enhance immunity 2. (-)-Fucose is a skin moisturizing and delaying skin aging 3. (-)-Fucose is a nutritional supplement

Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.

(20R)-Ginsenoside Rg3 (20(R)-Propanaxadiol) is a compound with anti-aging and antifatigue activities.

Pulchinenoside A (Anemoside A3) is an attractive candidate for further development as a cognitive enhancer capable of alleviating memory dysfunctions associated with aging and neurodegenerative diseases.

IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model [1] [2]. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which is able to be used for the research of solid tumors [3].