aggressive — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2556	Nandrolone decanoate	19-Nortestosterone decanoate	Others , HIV Protease
	Nandrolone decanoate (19-Nortestosterone decanoate) is the decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enter...		Others , HIV Protease
T23483	U 99194 maleate	U-99194A maleate,U-99194 maleate salt,U-99194 maleate	Dopamine Receptor
	U 99194 maleate (U-99194A maleate) is a D3 antagonist and increases social behaviors of isolation-induced aggressive male mice.		Dopamine Receptor
T11421	Glutaminase-IN-1	CB839 derivative	transporter
	Glutaminase-IN-1 (CB839 derivative), a novel 1,3,4-selenodiazepine renal-type glutaminase (KGA) variant inhibitor, showed antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.		transporter
T17206	UPGL00004		Others , Glutaminase
	UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM. Kd of UPGL00004 for GAC was 27 nM. UPGL00004 has a strong inhibitory effect on the proliferation of highly aggressive triple negative breast canc...		Others , Glutaminase
T3275	Nefazodone hydrochloride	Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754	5-HT Receptor , Adrenergic Receptor
	Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.		5-HT Receptor , Adrenergic Receptor
T24519	Naprodoxime HCl	Naprodoxime hydrochloride,L 7660,L7660,L-7660
	Naprodoxime HCl is an antidepressant. It also is an anti-aggressive agent.
T68189	Anpirtoline free base
	Anpirtoline free base is a highly potent 5-HT1B receptor agonist. Anpirtoline has been shown to decreases central serotonin synthesis and attenuate aggressive behavior in vivo. Anpirtoline also acts as an antagonist at 5...
T28850	SR57227A	SR 57227A,SR-57227A
	SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreas...
T60760	HDAC10-IN-2
	HDAC10-IN-2 (compound 10c) regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells. HDAC10-IN-2 is a potent and highly selective inhibitor of HDAC10 (IC50 = 20 nM) [1].
T78526	4A3-SC8		Others
	4A3-SC8 is a modular, degradable dendrimer facilitating the extension of survival in aggressive liver cancer models through the delivery of small RNAs [1].		Others
T78145	HDAC10-IN-2 hydrochloride		Autophagy
	HDAC10-IN-2 hydrochloride (compound 10c) is an HDAC10 inhibitor with high potency and selectivity, exhibiting an IC50 of 20 nM. It influences autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1].		Autophagy
T80981	Tisagenlecleucel	CTL019
	Tisagenlecleucel (CTL019), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, selectively targets and eradicates CD19-expressing B cells, and is utilized in the study of refractory aggressive diffuse...
T60794	HDAC10-IN-1
	HDAC10-IN-1 (compound 13b) is a potent and highly selective inhibitor of HDAC10 (IC 50 = 58 nM) that regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells [1].
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selecti...
T63368	CDK7-IN-2
	CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is involved in transcription initiation using phosphorylation of the Rbpl subunit of RNA polymerase II (RNAPII), which is associated with temporal control of cell cycle and t...
T68400	STA-9584
	STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphe...
T63902	XP-524
	XP-524 is a potent inhibitor of BET and EP300. XP-524 has significant tumouricidal effects in vivo, preventing KRAS-induced tumour transformation in vivo and prolonging survival in two aggressive PDAC transgenic mouse mo...
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro...