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Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.

AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C).

ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.

ACHN-975 is a highly potent and selective LpxC inhibitor, demonstrating subnanomolar inhibitory activity. It effectively targets a broad spectrum of gram-negative bacteria, with low minimum inhibitory concentration (MIC) values (≤1 μg/mL)[1].

Plazomicin sulfate is a potent aminoglycoside antibiotic that combats antibiotic resistance. Plazomicin sulfate exhibits in vitro activity against multidrug-resistant bacteria including carbapenem-resistant Enterobacteriaceae. Plazomicin sulfate is utilized in antimicrobial susceptibility testing and infectious disease research models of multidrug-resistant complicated urinary tract infection (cUTI) and carbapenem-resistant Enterobacteriaceae infection systems.

Cyclostachnine is a useful organic compound for research related to life sciences and the catalog number is T131505.

Lachnanthocarpone is a member of the 6-oxygenated phenylphenalenones.

Lachnone A, a chromone derivative, has been isolated from the filamentous fungus Lachnum sp. BCC 2424 [1].

Tetrahydrolachnophyllum lactone is a natural product for research related to life sciences. The catalog number is TN5132 and the CAS number is 56407-87-5.

(Z)-Lachnophyllum lactone is a natural product for research related to life sciences. The catalog number is TN5803 and the CAS number is 81122-95-4.

Lachnumon is a fungal metabolite known for its nematocidal and antibacterial activities.

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.

Osajin is an isoflavonoid natural product isolated from the fruits of Maclura pomifera. It belongs to flavonoid derivatives, and studies have reported that it exhibits multiple biological activities, including anticancer, antioxidant, and anti-inflammatory effects.

Piericidin A is a natural mitochondrial NADH- ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A interferes with the electron transfer chain by inhibiting the activity of NADH- ubiquinone reductase, thus inhibiting mitochondrial respiration, which shows a certain neurotoxic effect. Piericidin A has potential quorum sensing inhibitory activity, antibacterial, antitumor and insecticidal activities.

Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities.

ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).

MMP-2Inhibitor-4 (Compound 5g) is an MMP-2 inhibitor with an IC50 of 152.62 nM. It effectively reduces MMP-2 levels in K562 cell lines by stably binding to the active site of MMP-2 and exhibits strong anti-angiogenic effects in ACHN cell lines. MMP-2Inhibitor-4 shows potential for research in chronic myelogenous leukemia (CML).

IT-143B is a bacterial metabolite that has been found in S. iakyrus.1 It inhibits the proliferation of OS-RC-2 and ACHN cancer cells (IC50s = 22 and 98 μM, respectively). |1. Li, K., Liang, Z., Chen, W., et al. Iakyricidins A-D, antiproliferative piericidin analogues bearing a carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. J. Org. Chem. 84(19), 12626-12631 (2019).

DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimics effects of Nur77 RNAi silencing.

4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.

Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating high efficacy against SNB-19, OVCAR-8, and NCI-H460 with PGIs of 86.61, 85.26, and 75.99, respectively. Moreover, it shows moderate activity against a range of other cancer cell lines — HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 — with PGIs between 51.88 and 67.55 [1].

Chrolactomycin exhibits IC50 values against ACHN, A431, McF-7, and T24 cells of 1.2 μM, 1.6 μM, 0.69 μM, and 0.45 μM, respectively. It is active only against Gram-positive bacteria, with a Minimum Inhibitory Concentration (MIC) ranging from 5.2 to 10.4 μg/mL.

Glucopiericidin A is a natural piperidine-based compound found in marine-derived Streptomyces strains. It serves as a chemical probe for glucose transporter proteins (GLUT) and can inhibit glycolysis. When combined with Piericidin A (PA), it synergistically inhibits ATP-dependent filopodia formation, yet has no effect alone. Glucopiericidin A induces apoptosis by increasing PRDX1, thereby reducing reactive oxygen species (ROS) levels, and also demonstrates potent antitumor activity in ACHN mouse xenografts.