tnik — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T9557	TNIK-IN-2		Wnt/beta-catenin
	TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.		Wnt/beta-catenin
T9556	TNIK-IN-3		Wnt/beta-catenin
	TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates...		Wnt/beta-catenin
T77719	TNIK-IN-7		Wnt/beta-catenin
	TNIK-IN-7 is a potent and selective Traf2 and Nck interacting kinase (TNIK) inhibitor (IC50: 11 nM) with antitumor activity for studying signaling and proliferation in colorectal cancer cells.		Wnt/beta-catenin
T26282	TNIK-IN-1	TNIK-inhibitor-1,TNIK inhibitor 1
	TNIK-IN-1 is an inhibitor of Traf2- and Nck-interacting kinase (TNIK).
T80971	TNIK-IN-6
	TNIK-IN-6 (Compound 9) acts as an inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an inhibitory concentration (IC50) of 0.93 μM, a kinase implicated in various neurological and psychiatric disorders [1] ...
T61396	TNIK-IN-4
	TNIK-IN-4, a powerful TNIK inhibitor, exhibits an IC50 value of 0.61 μM. Furthermore, it demonstrates inhibitory effects on the HCT116 cell line, which is representative of colorectal cancer [1].
T79794	TNIK&MAP4K4-IN-1
	TNIK&MAP4K4-IN-1 (compound A-39) is a potent dual inhibitor targeting TNIK and MAP4K4/HGK, exhibiting IC50 values of 1.29 nM and <10 nM, respectively, in human hepatic stellate cell LX-2. This compound is applicable in t...
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T26110	Robotnikinin
	Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.
T4011	NCB-0846	NCB 0846	MAPK , Wnt/beta-catenin
	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).		MAPK , Wnt/beta-catenin
T77660	TINK-IN-1		Wnt/beta-catenin
	TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.		Wnt/beta-catenin
T68051	Delequamine	RS 15385-197	Adrenergic Receptor
	Delequamine (RS 15385-197) is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.		Adrenergic Receptor
T5093	Pim1/AKK1-IN-1	LKB1/AAK1 dual inhibitor,MDK-2275	Pim , Hippo pathway
	Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.		Pim , Hippo pathway
T5483	DMX-5804	DMX-5084	MAPK
	DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.		MAPK
T79908	ON 108600		Casein Kinase
	ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.028 μM for DYRK2, 0.05 μM and 0.005 μM for CK2α1 and CK2α2, ...		Casein Kinase
T36016	PF 06260933 dihydrochloride
	MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active. Ammirati et al (2015) Discovery of an in vivo tool t...
T28370	PF-06279794	PF 794,PF794,PF-794,PF 06279794
	PF-06279794 is a potent, selective and ATP-competitive TNIK inhibitor.
T33945	PF-06260933 HCl	PF06260933 dihydrochloride,PF-06260933 dihydrochloride,PF 06260933 dihydrochloride
	PF-06260933 Dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). It can improve the fasting hyperglycemia in mice. In addition, it inhibited Mink and Tnik (IC50 values of 8 and 13 nM, respectively).