T6150

TAK-715 is a p38 MAPK inhibitor for p38α.

PLP_Snyder530 is a potent papain-like protease (PL pro) inhibitor that induces conformational changes in SARS-CoV-2 papain-like protease, thereby inhibiting SARS-CoV-2 replication; it can be used for SARS-CoV-2 research [1].

Topoisomerase I inhibitor 5 is an efficient topoisomerase I inhibitor with an IC50 value, effectively disrupting DNA and inhibiting topoisomerase I activity. It induces apoptosis in MCF-7 cells and arrests the cell cycle at the G1 phase, displaying potency in reversing P-gp-mediated resistance to Adriamycin [1].

Antifungal agent 32 (compound 1a) is a highly effective antifungal compound that strongly inhibits Candida albicans filamentation, biofilm formation, morphological switching, and adherence to epithelial cells, making it a valuable tool for research on Candida albicans infections [1].

α-Glucosidase-IN-15 (Compound 14B) exhibits potent α-glucosidase inhibitory activity with an IC50 value of 3.34 μM and possesses antidiabetic properties [1].

PKM2 activator 3 is a highly potent compound that activates PKM2, with an AC 50 value of 90 nM. It exhibits excellent Caco-2 permeability, a low efflux ratio, and remarkable microsomal stability. PKM2 activator 3 is particularly valuable for anticancer research purposes [1]. (AC 50: the concentration at which 50% enzyme activation occurs.)

CC-115 hydrochloride is a potent dual inhibitor of DNA-PK (IC50 = 13 nM) and mTOR kinase (IC50 = 21 nM), effectively blocking both mTORC1 and mTORC2 signaling pathways.

NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3].

5-HT2A receptor agonist-2 is a potent compound that acts as an agonist on the serotonin 5-HT2 receptor, specifically stimulating the 5-HT 2A, 5-HT 2B, and 5-HT 2C receptors with EC50 values of 1.7 nM, 0.58 nM, and 0.50 nM, respectively [1].

Meloxicam sodium is a non-steroidal anti-inflammatory agent that inhibits COX activity, with IC50 values of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively [1].

Neuraminidase-IN-8 (Compound 6d) is a potent neuraminidase inhibitor with a low IC50 of 0.027 μM, demonstrating significant anti-influenza activities [1].