T2004

Ciproxifan maleate (FUB 359)(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

Filgotinib analogue isa a structurally analogue of Filgotinib and can be used in life science related research.

2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.

Ethyl heptanoate is a RIFM spice that is produced and volatilized by the fermentation of eight packets of tempeh.

Vidarabine phosphate is an adenosine monophosphate analog. It is the monophosphate ester of VIDARABINE. It also has antiviral and possibly antineoplastic properties.

PAIB-SOs-12 is an anti-mitotic compound that shows anti-proliferative activity at low concentrations and induces cytoskeletal damage in MCF7 cells.

C.I. Acid Green 3 is a dull dark green powder.

KHK-IN-5 (Compound 18), a KHK inhibitor, is employed in the study of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and type 2 diabetes (T2DM).

TMV-IN-12 (compound4) serves as an inhibitor targeting Tobacco Mosaic Virus (TMV) and possesses antifungal properties. It effectively prevents the aggregation of TMV particles and the self-assembly of TMV coat protein (TMV-CP) with a dissociation constant (Kd) of 0.142 μM, thereby inhibiting TMV infections in tobacco plants.

Sulfamethoxazole-NO (SMX-NO) is a SMX-NO derivative that is a major immunogen for sulfonamide hypersensitivity reactions, is cytotoxic, and is immunogenic in rodents.

BML-286 is a WNT pathway modulator with potential anticancer activity, inducing β-catenin- and TCF-dependent transcriptional activity, and can be used in the study of degenerative diseases, intestinal, breast, bladder, gastric, melanoma, leukemia, hepatocellular carcinoma and nephroblastoma.

8-Azaadenine (NSC-32797) is an inhibitor of xanthine oxidase with IC50 of 0.54 μM and Ki of 0.66 μM.

Decanoyl-L-carnitine ((-)-Decanoylcarnitine) is a L-carnitine derivative that promotes the formation of saturated fatty acid metabolites.

PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC molecule targeting SMARCA2, exhibiting a DC50 of less than 100 nM and a maximum degradation rate (Dmax%) of over 90% in A549 cells after 24 hours of treatment.

LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.

1-Methyladenosine-D3 is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine (T7571) upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.

SHP2-IN-32 (compound C6) is an orally effective allosteric SHP2 inhibitor with an IC50 value of 0.13 nM. It demonstrates antitumor activity.

SMARCA2 degrader-4 (compound I-332) is a PROTAC-based degrader targeting the SMARCA2 protein, exhibiting a DC50 value of less than 100 nM in A549 cells and achieving a maximum degradation rate (Dmax%) of over 90% after a 24-hour treatment period.

And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.

FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.

AAZ-A 154 hydrobromide is a selective, competitive, non-hallucinogenic 5-HT2AR antagonist. It promotes neuronal growth in rodents and yields enduring beneficial behavioral effects.

Muvalaplin tetrahydrochloride (LY3473329) is an orally active lipoprotein (a)Lp(a) agent currently under investigation. Research on the oral formulation of Muvalaplin tetrahydrochloride is ongoing.

SARS-CoV-2 Mpro-IN-25 (Compound 3a) is a protease inhibitor for SARS-CoV-2, exhibiting an IC50 value of 0.26 μM. It demonstrates antiviral activity and is useful for research in the field of pneumonia.

GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.