snx — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28824	SNX0723	SNX 0723,SNX- 0723	HSP
	SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasit...		HSP
TP2118	SNX-482	SNX 482
	Potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.
T6305	SNX2112	SNX-2112,PF 04928473,SNX 2112	HSP
	SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.		HSP
T68393	SNX-7081
	NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to ...
T6341	PF04929113	PF-04929113,SNX-5422,PF 04929113	HSP , HER
	PF04929113 (SNX-5422) is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates strong efficacy and tolerability, PF04929113 is positioned as a breakthrough therapy with broad applic...		HSP , HER
T4342	PF-04929113 Mesylate	PF-04929113 (Mesylate),SNX-5422 Mesylate	HSP , HER
	PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).		HSP , HER
T80443	ω-Conotoxin MVIID	SNX-238	Calcium Channel
	ω-Conotoxin MVIID (SNX-238) is a peptide from the Conus genus that inhibits the ω-Conotoxin-GVIA-sensitive, high-threshold calcium (Ca 2+) current in fish retinal ganglion cells [1].		Calcium Channel
T77613	SNX7	WAY-323879	CDK
	SNX7 (WAY-323879) is an inhibitor of the cell cycle protein-dependent kinase inhibitor (CDKI) pathway. SNX7 can be utilized as a tool for investigating the aging process and other diseases associated with CDKI.		CDK
T24811	SNX2-1-108	SNX-21108,SNX21108,SNX 21108
	SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.
TP1559L	Ziconotide Acetate (107452-89-1 free base)	Prialt,Ziconotide Acetate	Calcium Channel
	Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...		Calcium Channel
T81137	SNX7886		PROTACs
	SNX7886 is a potent PROTAC (proteolysis-targeting chimera) that effectively degrades CDK8 and CDK19, achieving 90% degradation of CDK8 and 80% degradation of CDK19 in 293 cells [1].		PROTACs
T18018	HS-27		Others , HSP
	HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-and-treat paradigms.		Others , HSP
T75710	Ziconotide TFA
	Ziconotide TFA (SNX-111 TFA), a peptide-based, potent, and selective N-type calcium channels antagonist, effectively reduces synaptic transmission and is utilized in chronic pain research [1].

Compounds

SNX0723

T28824

Synonym: SNX 0723,SNX- 0723

Synonym: SNX-2112,PF 04928473,SNX 2112

Synonym: PF-04929113,SNX-5422,PF 04929113

Target: HSP, HER

PF-04929113 Mesylate

T4342

Synonym: PF-04929113 (Mesylate),SNX-5422 Mesylate

Target: Calcium Channel

Synonym: SNX-21108,SNX21108,SNX 21108

Target:

Ziconotide Acetate (107452-89-1 free base)

TP1559L

Synonym: Prialt,Ziconotide Acetate

Target: Calcium Channel

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00888	ANXA7 Protein, Human, Recombinant	Human	E. coli
	Annexin A7 (ANXA7) is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin A7 has a unique, highly hydrophobic N-terminal domain and a conserved C-terminal region. The C-terminal reg...
TMPH-02127	SNX16 Protein, Human, Recombinant (His)	Human	E. coli
	May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF si...
TMPH-02301	VPS35 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transm...