grp78 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T67897	GRP78-IN-3		HSP
	GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of...		HSP
T63243	GRP78-IN-2
	GRP78-IN-2 is a glucose regulatory protein 78 (GRP78) inhibitor that preferentially targets GRP78 on the cell surface and has significant anti-angiogenic and anti-cancer effects without affecting other normal cells.
T61106	GRP78-IN-1
	GRP78-IN-1 displays interactions with specific residues on the GRP78 protein with a binding energy of -8.07 kcal/mol. This compound possesses potent cytotoxic and anti-proliferative effects on cancer cells, particularly ...
T30480	BiP inducer X	BIX	Apoptosis
	BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.		Apoptosis
T8901	YUM70		Apoptosis , GPR , HSP
	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate...		Apoptosis , GPR , HSP
T7010	VER-155008	VER155008	GPR , HSP , Autophagy
	VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, >100-fold selectivity over HSP90.		GPR , HSP , Autophagy
T67717L	Questiomycin A derivatives 18 TFA
	Questiomycin A derivatives 18 TFA is A Questiomycin A derivative with antibacterial and anticancer activity and inhibition of the expression of the cell-protective ER chaperone protein GRP78.
T36818	Questiomycin A		GPR , Antibacterial
	Questiomycin A is an antibiotic produced in crème fraiche with antibacterial and anticancer activities. Questiomycin A suppresses expression of GRP78, a cell-protective ER chaperone protein.		GPR , Antibacterial
T6855	HA15		Apoptosis , GPR , Others , HSP , Autophagy
	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.		Apoptosis , GPR , Others , HSP , Autophagy
T39423	Palmitic acid-13C sodium
	Sodium palmitate-13C is the 13C-labeled variant of palmitic acid, a long-chain saturated fatty acid prevalent in animals and plants. This compound has been shown to induce the expression of glucose-regulated protein 78 (...
T40141	Palmitic acid-13C16 sodium	Palmitic acid-13C16 sodium
	Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated prote...
T38471	HM03 trihydrochloride
	HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.
T40980	Palmitic acid-13C2	Palmitic acid-13C2
	Palmitic acid-13C2 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (...
TN2371	Isoliquiritin	Neoisoliquiritin	Others
	Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway		Others
T72543	BOLD-100 free base	NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base
	BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded pr...