gpx4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T77755	GPX4-IN-5		GPX
	GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces iron death and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).		GPX
T77759	GPX4-IN-6		GPX
	GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-6 induces iron death and is used for the treatment= and prevention of triple negative breast cancer (TNBC).		GPX
T36935	PKUMDL-LC-101-D04	GPX4-Activator-1d4,PKUMDL-LC-101-D04	GPX
	PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free...		GPX
T83780	GPX4 24	Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
	GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e...
T74846	GPX4-IN-4		Glutathione Peroxidase
	GPX4-IN-4 (Compound 24) serves as a potent inhibitor of GPX4, applicable in cancer research [1].		Glutathione Peroxidase
T63729	GPX4-IN-3
	GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM [1].
T73235	GPX4-IN-2
	GPX4-IN-2 is a potent inhibitor of GPX4, exhibiting antiproliferative activity. It holds potential for cancer research applications.
T79777	GPX4-IN-7		Ferroptosis
	GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits HCT-116 cell growth with an IC50 of 0.49 μM. This compound ...		Ferroptosis
T74796	PROTAC GPX4 degrader-1
	PROTAC GPX4 Degrader-1 (DC-2) is a PROTAC-based compound that efficiently degrades GPX4, demonstrating a degradation concentration (DC 50) of 0.03 μM in HT1080 cells [1].
T4066	FIN56		Ferroptosis
	FIN56 is a specific inducer of ferroptosis.		Ferroptosis
T8970	ML162		Ferroptosis , GPX , Glutathione Peroxidase
	ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)		Ferroptosis , GPX , Glutathione Peroxidase
T11631	IFSP1		Ferroptosis
	iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse human cancer cell lines to ferroptosis inducers like (1S,3R)-RS...		Ferroptosis
T8375	ML-210	CID 49766530	Ferroptosis , GPX , Glutathione Peroxidase , Ras
	ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity		Ferroptosis , GPX , Glutathione Peroxidase , Ras
T37314	JKE-1674		GPX
	JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.		GPX
T60084	FINO2		Ferroptosis
	FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels. Furthermore, FINO2 i...		Ferroptosis
T77745	N6F11		GPX
	N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.N6F11 can be used to study pancreatic cancer.		GPX
T3646	RSL3	RSL3 1S,1S,3R-RSL3	Ferroptosis , GPX , Glutathione Peroxidase
	RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.		Ferroptosis , GPX , Glutathione Peroxidase
T79294	NC-R17		Glutathione Peroxidase
	NC-R17, an RSL3-based noncovalent GPX4 degrader implicated in ferroptosis, demonstrates anti-tumor activity and is utilized in the design of noncovalent GPX4-targeted proteolysis targeting chimeras (PROTACs) [1].		Glutathione Peroxidase
T37805	JKE-1716
	JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi...
T62827	BCP-T.A
	BCP-T.A is a heterocyclic electrophile that binds GPX4 and thus effectively induces iron death (ferroptosis).
T79639	Lepadin H		Ferroptosis
	Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing lipid peroxidation. It simultaneously decreases SLC7A11 and GP...		Ferroptosis
T79638	Lepadin E		Glutathione Peroxidase
	Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation...		Glutathione Peroxidase
T68239	NPD4928
	NPD4928 enhanced the sensitivity of various cancer cells to GPX4 inhibitors, suggesting that the combination might have therapeutic potential via the induction of ferroptosis.
T79388	Anticancer agent 154		Reactive Oxygen Species
	Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage. It triggers ferroptosis by depleting GSH, diminishing GPX4 express...		Reactive Oxygen Species
T36516	RC574	RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons...
T37487	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE b...
T83886	IcFSP1 TFA
	icFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 µM concentration but does not affect FSP1's enzymatic function in cell-f...
T36515	RC363
	RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a...
T36514	QD-394
	QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to...

Compounds

GPX4-IN-5

T77755

Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04

Target: GPX

GPX4 24

T83780

Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

Target: Glutathione Peroxidase

PROTAC GPX4 degrader-1

Target: Ferroptosis, GPX, Glutathione Peroxidase

Synonym: CID 49766530

Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras

Synonym: RSL3 1S,1S,3R-RSL3

Target: Ferroptosis, GPX, Glutathione Peroxidase

NC-R17

T79294

Synonym:

Target: Glutathione Peroxidase

Target: Glutathione Peroxidase

Target: Reactive Oxygen Species

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

Cat No.	Product Name	Synonyms	Targets
TN5770	Gingerenone A		Nrf2
	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DS...		Nrf2

Cat No.	Product Name	Species	Expression System
TMPY-06701	GPX4 Protein, Human, Recombinant (His)	Human	E. coli
	GPX4 Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 20.59 kDa. Accession number: P36969

Cat No.	Product Name
L8700	Ferroptosis Compound Library		800 compounds
	A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；

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