dasatinib — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1448	Dasatinib	BMS-354825	Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
	Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive. Dasatinib has antitumor activity and is used in the treatment of leukemia and ly...		Apoptosis , Bcr-Abl , Src , c-Kit , Autophagy
T18595	Dasatinib carbaldehyde	PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde	Others , Ligands for Target Protein for PROTAC
	Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].		Others , Ligands for Target Protein for PROTAC
T1448L	Dasatinib monohydrate	BMS-354825 Monohydrate	Apoptosis , Bcr-Abl , Src , c-Kit , Ephrin Receptor , Autophagy
	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activit...
T37600	Dasatinib N-oxide		Others
	Dasatinib N-oxide is a major metabolite of the Abl and Src kinase inhibitor dasatinib.It is also a potential impurity in commercial preparations of dasatinib[1][2].		Others
T22303	Dasatinib hydrochloride	BMS-354825 HCl	Bcr-Abl , Src , c-Kit
	Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bc...		Bcr-Abl , Src , c-Kit
T18750	N-Deshydroxyethyl Dasatinib	N-Deshydroxyethyl BMS-354825	Others , IAP , Drug Metabolite
	N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.N-Deshydroxyethyl Dasatinib i...		Others , IAP , Drug Metabolite
T10962	Dasatinib-d8	BMS-354825 D8	Others
	Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.		Others
T37645	Dasatinib metabolite M6
	Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib, a potent and orally active inhibitor of both Bcr-Abl and Src family tyrosine kinases[1].
T30540	BMS-748730	4′-Hydroxy Dasatinib,,Dasatinib metabolite M20
	BMS-748730, also known as 4′-Hydroxy Dasatinib, is a Dasatinib metabolite.
T71581	SGX393
	SGX393 is an inhibitor of the CML mutant Bcr-AblT315I, thereby preempting in vitro resistance when combined with nilotinib or dasatinib.
T18686	SNIPER(ABL)-019		Others
	SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].		Others
T18690	SNIPER(ABL)-039		Others
	SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, c...		Others
T18687	SNIPER(ABL)-020		Others
	SNIPER(ABL)-020 is a chemical compound consisting of Dasatinib, an ABL inhibitor, and Bestatin, an IAP ligand, conjugated with a linker. This compound effectively reduces the BCR-ABL protein[1].		Others
T71654	APcK110
	APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3...
T83930	SJ 11646
	SJ 11646, a potent lymphocyte-specific protein tyrosine kinase (LCK) Degrader (PROTAC) with a DC50 of 0.00838 pM, utilizes Dasatinib as the LCK ligand and incorporates a phenyl glutarimide-based cereblon binder. Demonstr...
T79711	Antitumor photosensitizer-4		Apoptosis
	Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. This photosensitizer (PS) induces apoptosis and reactive oxygen speci...		Apoptosis