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Search Results for " colo205 "

10

Compounds

Cat No. Product Name Synonyms Targets
T5858 Sertindole Lu 23-174 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T2S0357 6-Hydroxycoumarin 6-hydroxychromen-2-one Others , Carbonic Anhydrase
6-Hydroxycoumarin (6-hydroxychromen-2-one) exhibits cytotoxicity against human HL60, HCT116, COLO205 cells with activity value of 35 uM, 42 uM, 37 respectively. 6-Hydroxycoumarin is a human CA9, CA12 inhibitor.
T79592 COX-1/2-IN-4 COX
COX-1/2-IN-4 (compound 2b) is a dual COX-1 and COX-2 inhibitor with respective IC50 values of 0.239 μM for COX-1 and 0.191 μM for COX-2. Additionally, it demonstrates moderate anticancer activity, exhibiting IC50 values ...
T70424 EBI-907
EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also...
T78763 ABCB1-IN-1
ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis. Featuring 1-benzylimidazole, it exhibits IC50 values of 1.26 μM for Colo205 cells and 2.21 μM for Colo320 cells, respectively [1].
T79112 CDK4/6-IN-17 CDK
CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells. It has shown efficacy in inhibiting tumor growth in the COLO205 x...
T60659 Cdc7-IN-12
Cdc7-IN-12 (compound 1) is a potent inhibitor of CDC7 (IC 50 of <1 nM) that has the potential in the cancer research. Cdc7-IN-12 exhibits antiproliferative activities in COLO205 cells with IC 50 of 100-1000 nM [1].
T62939 SHR2415
SHR2415 is a selective, potent, orally active inhibitor of ERK1/2. SHR2415 inhibits ERK1 (IC50: 2.8 nM) and ERK2 (IC50: 5.9 nM). SHR2415 exhibits high potency in Colo205 cells (IC50: 44.6 nM). SHR2415 can be used in canc...
T61436 Cdc7-IN-18
Cdc7-IN-18 (compound 1-2) is a highly effective inhibitor of the CDC7 enzyme. It has an IC 50 value of 1.29 nM for the Cdc7/DBF4 enzyme. In addition, this compound exhibits strong antiproliferative activities, with an IC...
T69221 BMS-554417
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 fo...
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