Ac2-26 TFA

Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.

Ac2-26, an annexin A1 mimetic peptide, was able to attenuate renal inflammatory injury in a diabetic mouse model through inhibition of p38MAPK NF-κB, as well as sepsis-induced cardiomyocyte apoptosis through the LXA4 PI3K AKT signalling pathway, and hepatic ischaemia-reperfusion injury in mice by modulating IL-22 IL-22R1 STAT3 signalling pathway.