70s ribosome

Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis in both prokaryotic and eukaryotic cells by interfering with translocation and causing mistranslation by the 70S ribosome. It is commonly used for the selection of cells transfected with the hph or hyg resistance gene.

Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Capreomycin sulfate (Capastat sulfate) , a cyclic peptide antibiotic, binds to the 70S ribosomal unit leading to inhibition of protein synthesis.

Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Chloramphenicol acts primarily on the 50S subunit of the bacterial 70S ribosome and is active against peptidyltransferases, inhibiting the formation of peptide bonds.

PNU-177553 is an oxazolidinone compound. It binds exclusively to the 50S ribosomal subunit and demonstrates a similar affinity for the 70S ribosome, with no affinity for the 30S subunit of oxazolidinones.

Azithromycin-amide-C3-amide-quinoxaline (Compound 5f) is a derivative of Azithromycin and serves as an antibacterial agent. It inhibits topoisoisomerase I with an IC50 of 120.7 μM. The compound binds to the Escherichia coli 70S ribosome with a Kd of 0.8 nM and suppresses bacterial translation with an IC50 of 0.7 μM. It shows antibacterial activity against Streptococcus pneumoniae ATCC 49619, Staphylococcus aureus ATCC 29213, and Enterococcus faecalis ATCC 29212, with MIC values of 0.06 μg/mL, 2 μg/mL, and 0.5 μg/mL, respectively. Additionally, this compound exhibits anticancer activity against prostate and colorectal cancer.

Telithromycin is a semisynthetic 14-membered macrolide antibiotic and erythromycin derivative that binds to the 50S subunit of the 70S bacterial ribosome, inhibits bacterial protein synthesis, and exhibits antimicrobial activity against a wide range of gram-positive and gram-negative bacteria for the treatment of mild to moderate respiratory infections.

Api137 is an antimicrobial peptide that disrupts bacterial growth by blocking translation processes, specifically inhibiting protein synthesis by entrapping release factors on the 70S ribosome after hydrolysis of the nascent polypeptide chain [1][2].

Chloramphenicol (Standard) is the standard substance of Chloramphenicol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Chloramphenicol acts primarily on the 50S subunit of the bacterial 70S ribosome and is active against peptidyltransferases, inhibiting the formation of peptide bonds.

Hygromycin B (Standard) is the standard substance of Hygromycin B, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis in both prokaryotic and eukaryotic cells by interfering with translocation and causing mistranslation by the 70S ribosome. It is commonly used for the selection of cells transfected with the hph or hyg resistance gene.

Albomycin δ1 is a selectively targeting bacterial ribosome antibiotic (antibiotic) with a minimum inhibitory concentration (MIC) of 0.0625 μg/mL against S. pneumoniae. It exerts its bactericidal effect by covalently binding to the 70S ribosome and irreversibly inhibiting peptidyl transferase. Albomycin δ1 holds promise for research on infections caused by S. pneumoniae and S. aureus.