17α-hydroxyprogesterone

17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

17α-Hydroxyprogesterone-d8 is a deuterated compound of 17α-Hydroxyprogesterone.

17α-Hydroxyprogesterone-D8 (Standard) is a reference standard of 17α-Hydroxyprogesterone-D8 intended for quantitative analysis, quality control, and related biochemical research applications. 17α-Hydroxyprogesterone-d8 is a deuterated compound of 17α-Hydroxyprogesterone.

17α-Hydroxyprogesterone acetate is a compound with progestational activity and exhibits anti-inflammatory effects at the murine maternal-fetal interface.

17α-Hydroxyprogesterone (Standard) is the standard substance of 17α-Hydroxyprogesterone, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

17α-Hydroxyprogesterone-[2,3,4-13C3] (Standard) is a reference standard of 17α-Hydroxyprogesterone-[2,3,4-13C3] intended for quantitative analysis, quality control, and related biochemical research applications.

Hydroxyprogesterone caproate (Delalutin) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.

Gestonorone is steroid progesterone in the 19-nometroprogesterone and 17α -hydroxyprogesterone groups.

Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol. Biol.15610-16(2016) 2.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 3.Disorders of steroidogenesis guide to steroid profiling and biochemical diagnosis1(2019) 4.Shackleton, C.H.L.Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesisLipids47(1)1-12(2012)

Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning......

Compound T40380(SC) (Standard) is the standard substance of Compound T40380(SC), and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate shows antiinflammatory effects at the murine maternal-fetal interface.

Hydroxyprogesterone caproate (Standard) is the standard substance of Hydroxyprogesterone caproate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydroxyprogesterone caproate (Delalutin) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system and inhibits ovulation and an alteration in the cervical mucus and endometrium.