αpyridone

α-Pyridone (2-Hydroxypyridine)e is the catalyst for generating β-oxopropyl carbonates from cyclic carbonates and alcohols and in the aminolysis of a polyglutamate.

1-(2-CYANOETHYL)-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDONE, with CAS No. 175277-60-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(2-CYANOETHYL)-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDONE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

TCS PIM-1 1 (SC 204330)(sc-204330) is an effective and specific ATP-competitive Pim-1 kinase inhibitor (IC50: 50 nM), exhibiting good specificity over MEK1/MEK2 and Pim-2 (IC50s > 20,000 nM).

1-Methyl-2-pyridone ,with CAS No. 694-85-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Methyl-2-pyridone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3-Methyl-2-pyridone ,with CAS No. 1003-56-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3-Methyl-2-pyridone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3,5-Dichloro-2-pyridone ,with CAS No. 5437-33-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3,5-Dichloro-2-pyridone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(2-Cyanoethyl)-5-(trifluoromethyl)-2(1H)-pyridone ,with CAS No. 175277-71-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(2-Cyanoethyl)-5-(trifluoromethyl)-2(1H)-pyridone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Methyl-4-pyridone-3-carboximide is an organic compound with utility in life science research, and 1-Methyl-4-pyridone-3-carboximide serves as a useful intermediate and model structure in biochemical and pharmacological studies, contributing to investigations of nicotinamide-related pathways and expanding its relevance as a versatile chemical probe in metabolic and biomedical research applications.

Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.

4-Bromo-2-hydroxypyridine is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase [IC50 values of 173 nM for PRL-1, 277 nM for PRL-2, and 128 nM for PRL-3], and induces p130Cas cleavage and apoptosis with anticancer effects.

Aspyridone A is a natural product for research related to life sciences. The catalog number is TN6092 and the CAS number is 935863-26-6.

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.