1. Periplogenin (Desoxostrophanthidin) plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties.

Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] (Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside]) is a carmenolide extracted from Periploca sepium.

Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca.

Sepiumol A is a polyphenolic compound isolated from the root bark of Periploca sepium, which has significant antifungal activity and inhibits methicillin-resistant Staphylococcus aureus, and can be used in the study of fungal infections.

Perisesaccharide C is a natural product

Periplocoside N is a natural product isolated from Periploca sepium, demonstrating insecticidal activity against red fire ants.

Perisesaccharide B is a natural product

Beta-Amyrin palmitate may release norepinephrine from newly synthesized pools, and thus, it may activate noradrenergic activity. Beta-Amyrin palmitate, like mianserin and imipramine, reduces the duration of immobility of mice significantly in a dose-depen

Acetyl Perisesaccharide C is a natural product

Periplocoside M is a natural product isolated from Periploca sepium exhibiting inhibitory effects on A-549 and HepG2 cells (IC50=4.84/7.06 μM).