1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.

1. Periplogenin (Desoxostrophanthidin) plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties.

Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] (Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside]) is a carmenolide extracted from Periploca sepium.

Periplocymarin is a cardiac glycoside with anticancer potential isolated from Periploca sepium and Periploca graeca.

Sepiumol A is a polyphenolic compound isolated from the root bark of Periploca sepium, which has significant antifungal activity and inhibits methicillin-resistant Staphylococcus aureus, and can be used in the study of fungal infections.

Perisesaccharide C is a natural product

Periplocoside N is a natural product isolated from Periploca sepium, demonstrating insecticidal activity against red fire ants.

Perisesaccharide B is a natural product

Beta-Amyrin palmitate may release norepinephrine from newly synthesized pools, and thus, it may activate noradrenergic activity. Beta-Amyrin palmitate, like mianserin and imipramine, reduces the duration of immobility of mice significantly in a dose-depen

Acetyl Perisesaccharide C is a natural product

Periplocoside M is a natural product isolated from Periploca sepium exhibiting inhibitory effects on A-549 and HepG2 cells (IC50=4.84/7.06 μM).