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iGluR

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are activated by the neurotransmitter glutamate.[1] They mediate the majority of excitatory synaptic transmission throughout the central nervous system and are key players in synaptic plasticity, which is important for learning and memory. iGluRs have been divided into four subtypes on the basis of their ligand binding properties (pharmacology) and sequence similarity: AMPA receptors, kainate receptors, NMDA receptors and delta receptors.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6504 Flupirtine maleate 75507-68-5 98.99%
Flupirtine maleate
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
T7870 TCN 201 852918-02-6 98.97%
TCN 201
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
T2S2264 Linalool 78-70-6 98.95%
Linalool
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
T10307 AMPA receptor modulator-1 2036074-41-4 98.82%
AMPA receptor modulator-1
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
T31208 Dasolampanel 503294-13-1 98.81%
Dasolampanel
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, includi...
T7599 Sunifiram 314728-85-3 98.81%
Sunifiram
Sunifiram (DM-235) is a potent nootropic agent.
T62042 BDZ-g 732278-52-3 98.77%
BDZ-g
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of...
T72662 NMDAR/TRPM4-IN-2 2243506-33-2 98.77%
NMDAR/TRPM4-IN-2
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
T21584 CP 465022 199655-36-2 98.75%
CP 465022
CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kain...
T16524 Philanthotoxin 74 dihydrochloride 1227301-51-0 98.6%
Philanthotoxin 74 dihydrochloride
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
T8458 CNQX disodium 479347-85-8 98.46%
CNQX disodium
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.
T13248 UK-240455 178908-09-3 98.34%
UK-240455
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
T61813 AMPA receptor antagonist-3 923272-18-8 98.24%
AMPA receptor antagonist-3
AMPA receptor antagonist-3 is an AMPA receptor antagonist.
T61068 AMPA receptor antagonist-2 732277-05-3 98.21%
AMPA receptor antagonist-2
AMPA receptor antagonist-2 is an AMPA receptor antagonist.
T62839 Dalzanemdor 1629853-48-0 98.20%
Dalzanemdor
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dys...
T12733 Rislenemdaz 808732-98-1 98.18%
Rislenemdaz
Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
T15623 JNJ-61432059 2035814-50-5 98.13%
JNJ-61432059
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1...
T4113 NBQX 118876-58-7 98.02%
NBQX
NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
T1589 D-Cycloserine 68-41-7 98%
D-Cycloserine
D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with oth...
T7579 1-BCP 34023-62-6 98%
1-BCP
1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.
Flupirtine maleate
T6504
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
TCN 201
T7870
TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.
Linalool
T2S2264
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Lina...
AMPA receptor modulator-1
T10307
AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.
Dasolampanel
T31208
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, includi...
Sunifiram
T7599
Sunifiram (DM-235) is a potent nootropic agent.
BDZ-g
T62042
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of...
NMDAR/TRPM4-IN-2
T72662
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retina...
CP 465022
T21584
CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kain...
Philanthotoxin 74 dihydrochloride
T16524
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
CNQX disodium
T8458
CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.
UK-240455
T13248
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parki...
AMPA receptor antagonist-3
T61813
AMPA receptor antagonist-3 is an AMPA receptor antagonist.
AMPA receptor antagonist-2
T61068
AMPA receptor antagonist-2 is an AMPA receptor antagonist.
Dalzanemdor
T62839
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dys...
Rislenemdaz
T12733
Rislenemdaz (CERC-301) (CERC-301) is an antagonist of the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B).
JNJ-61432059
T15623
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1...
NBQX
T4113
NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
D-Cycloserine
T1589
D-Cycloserine (RO-1-9213) is a broad spectrum antibiotic used as a second line agent for treatment of drug resistant tuberculosis, always in combination with oth...
1-BCP
T7579
1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.
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TargetMol