Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.

Cat. No.	Product name	CAS No.	Purity
T13858	RA190	1617495-03-0	98%
T13858	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
TN1262	3-Feruloylquinic acid	1899-29-2	98%
TN1262	3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
T7369L	Gemigliptin Tartrate(911637-19-9 free base)	1374639-74-3	98%
T7369L	Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombina...
T2493	PD 151746	179461-52-0	98%
T2493	PD151746 is a calpain inhibitor that exhibits a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). IC50 value: 0.26 ± ...
T2154	MG-132	133407-82-6	98%
T2154	MG-132 is a potent cell-permeable 26S proteasome inhibitor (IC50: 100 nM). It also inhibits calpain (IC50: 1.2 μM).
T6583	MG-101	110044-82-1	98%
T6583	MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T4042	Talabostat mesylate	150080-09-4	98%
T4042	Talabostat mesylate is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation ...
T14005	1G244	847928-32-9	98%
T14005	1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki ...
T10061	(1S,2S)-Bortezomib	1132709-14-8	98%
T10061	(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.
T6432	Calpeptin	117591-20-5	98%
T6432	Calpeptin is a potent, cell-permeable calpain inhibitor.
T8397	Ixazomib citrate	1239908-20-3	98%
T8397	Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential ...
T21854	Proteasome inhibitor IX	856849-35-9	98%
T21854	AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). AM 114 shows potent anticancer activity. AM 114 exhibits HCT116 p53+/+ c...
T17011	TCH-165	1446350-60-2	98%
T17011	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanc...
T2016	MLN9708	1201902-80-8	98%
T2016	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 is MLN2...
T2122	Ixazomib	1072833-77-2	98%
T2122	MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC5...
T6237	Trelagliptin	865759-25-7	98%
T6237	Trelagliptin is a highly specific and long-acting DPP-4 inhibitor.
T12710	Retagliptin Phosphate	1256756-88-3	98%
T12710	Retagliptin Phosphate is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.
T1502	Vildagliptin	274901-16-5	98%
T1502	Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiet...
TQ0038	Brensocatib	1802148-05-5	98%
TQ0038	AZD7986 is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).
T9090	MUN57694	858557-69-4	98%
T9090	MUN57694 is an inhibitor of 26S proteasome.