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Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.
Cat. No. Product name CAS No. Purity Chemical Structure
T13858 RA190 1617495-03-0 98%
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
TN1262 3-Feruloylquinic acid 1899-29-2 98%
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
T7369L Gemigliptin Tartrate(911637-19-9 free base) 1374639-74-3 98%
Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombina...
T2493 PD 151746 179461-52-0 98%
PD151746 is a calpain inhibitor that exhibits a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). IC50 value: 0.26 ± ...
T2154 MG-132 133407-82-6 98%
MG-132 is a potent cell-permeable 26S proteasome inhibitor (IC50: 100 nM). It also inhibits calpain (IC50: 1.2 μM).
T6583 MG-101 110044-82-1 98%
MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T4042 Talabostat mesylate 150080-09-4 98%
Talabostat mesylate is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation ...
T14005 1G244 847928-32-9 98%
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki ...
T10061 (1S,2S)-Bortezomib 1132709-14-8 98%
(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.
T6432 Calpeptin 117591-20-5 98%
Calpeptin is a potent, cell-permeable calpain inhibitor.
T8397 Ixazomib citrate 1239908-20-3 98%
Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential ...
T21854 Proteasome inhibitor IX 856849-35-9 98%
AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). AM 114 shows potent anticancer activity. AM 114 exhibits HCT116 p53+/+ c...
T17011 TCH-165 1446350-60-2 98%
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanc...
T2016 MLN9708 1201902-80-8 98%
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 is MLN2...
T2122 Ixazomib 1072833-77-2 98%
MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC5...
T6237 Trelagliptin 865759-25-7 98%
Trelagliptin is a highly specific and long-acting DPP-4 inhibitor.
T12710 Retagliptin Phosphate 1256756-88-3 98%
Retagliptin Phosphate is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.
T1502 Vildagliptin 274901-16-5 98%
Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiet...
TQ0038 Brensocatib 1802148-05-5 98%
AZD7986 is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).
T9090 MUN57694 858557-69-4 98%
MUN57694 is an inhibitor of 26S proteasome.
RA190
T13858
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
3-Feruloylquinic acid
TN1262
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
Gemigliptin Tartrate(911637-19-9 free base)
T7369L
Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombina...
PD 151746
T2493
PD151746 is a calpain inhibitor that exhibits a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). IC50 value: 0.26 ± ...
MG-132
T2154
MG-132 is a potent cell-permeable 26S proteasome inhibitor (IC50: 100 nM). It also inhibits calpain (IC50: 1.2 μM).
MG-101
T6583
MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
Talabostat mesylate
T4042
Talabostat mesylate is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation ...
1G244
T14005
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki ...
(1S,2S)-Bortezomib
T10061
(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.
Calpeptin
T6432
Calpeptin is a potent, cell-permeable calpain inhibitor.
Ixazomib citrate
T8397
Ixazomib citrate is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential ...
Proteasome inhibitor IX
T21854
AM 114 is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). AM 114 shows potent anticancer activity. AM 114 exhibits HCT116 p53+/+ c...
TCH-165
T17011
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanc...
MLN9708
T2016
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 is MLN2...
Ixazomib
T2122
MLN2238, a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC5...
Trelagliptin
T6237
Trelagliptin is a highly specific and long-acting DPP-4 inhibitor.
Retagliptin Phosphate
T12710
Retagliptin Phosphate is pharmaceutical composition of DPP-4 inhibitor, for treating type-2 diabetes.
Vildagliptin
T1502
Vildagliptin is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiet...
Brensocatib
TQ0038
AZD7986 is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).
MUN57694
T9090
MUN57694 is an inhibitor of 26S proteasome.
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