yangambin

Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels. Yangambin also has central nervous system activity.

Diayangambin (Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether) is a compound that inhibits cell proliferation with an IC50 of 1.5 μM in human monocytes and demonstrates immunosuppressive and anti-inflammatory activities [1].

De-4'-O-methylyangambin exhibits antibacterial effects. It also has analgesia activity.

Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Epiyangambin exhibits significant inhibition of the transformation of murine epidermal JB6 cells, with the IC50 value of 0.15 microg mL. (+)-Epiyangambin also has anti-platelet aggregation activity.