withanolide a

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

Withanolide C is a natural product from Physali alkekengi.

Withanolide S is a natural product for research related to life sciences. The catalog number is TN5258 and the CAS number is 63139-16-2.

Withanolide A (Standard) is a reference standard for research and analysis in studies involving Withanolide A. Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide known for inducing apoptosis, exhibits antiproliferative effects on HeLa, A-549, and MCF-7 human cancer cell lines, as well as on normal Vero cells [1].

Withasomniferolide B, a withanolide, can be obtained through isolation from a methanol extract of Withania somnifera roots, which acts as a positive activator of the GABA(A) receptor [1].

Withasomniferolide A, a withanolide extracted from the roots of Withania somnifera, has been identified as a positive activator of the GABAA receptor, isolated using a methanol extract [1].

Withaphysalin R (compound 5), a withanolide derived from the Solanaceae family, possesses an ergosterol-based steroid ester structure. This compound exhibits notable activities such as cytotoxic, immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant effects [1].

Physagulide J, a withanolide compound extracted from Physalis angulata L., exhibits anti-inflammatory and anti-tumor properties [1].

4,27-Dimethyl withaferin A, a synthetic analog of withanolide natural products, exhibits potential in the study of neurodegenerative diseases[1].

Withanolide, specifically (22R)-27-Hydroxy-1-oxowitha-2,5,24-trienolide, is a natural product that can be isolated from the aerial parts of the halophyte Datura stramonium [1].

Orpinolide, a withanolide analog, exhibits anti-leukemic properties. It disrupts the homeostasis of the Golgi apparatus, a process associated with the signaling of phosphatidylinositol 4-phosphate at the interface of the endoplasmic reticulum and Golgi membranes.

Withanolide B (Standard) is a reference standard for research and analysis in studies involving Withanolide B. Withanolide B, a natural product isolated from Withania somnifera Dunal, promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) via the ERK1/2 and Wnt/β-catenin signalling pathways, thereby enhancing bone healing. Withanolide B exhibits affinity for the catalytic domain of PARP-1.

Physagulide Y (2) is a withanolide with anticancer properties, functioning as a GLUT1 inhibitor.

Withacoagin is a withanolide isolated from the roots of Indian ginseng. It exhibits various biological activities, including adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin modulates the activity of several enzymes and pathways associated with oxidative stress and inflammation and can alleviate HIV-1 infection.

3β-Methoxy-2,3-dihydrowithaferin As is a natural withanolide isolated from Withania somnifera exhibiting inhibitory activity against ROR-alpha (IC₅₀=11.3 µM).

Dihydrowithaferin A is a withanolide isolated from Withania somnifera with activity against acetylcholinesterase (AChE). Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors.

Withanolide B, a natural product isolated from Withania somnifera Dunal, promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) via the ERK1/2 and Wnt/β-catenin signalling pathways, thereby enhancing bone healing. Withanolide B exhibits affinity for the catalytic domain of PARP-1.

2,3-Dihydro-3-methoxywithaferin A is a natural withanolide that exhibits cytotoxicity to human cancer cells and serves as a potential anticancer compound. Additionally, it protects normal cells against stress.