w 13

W 13 is a biochemical.

W13 is a potent inhibitor of MsbA and is an ATPase stimulator (EC50: 5.5 μM).

W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.

W000113414_I13 serves as an acid ceramidase (AC) inhibitor, demonstrating dose-dependent inhibition with an IC50 of 6.6 μM. It is applicable for cancer research [1].

Polyvinyl alcohol (Mw 13000-23000, 87-89% hydrolyzed) is a water-soluble polymer with a molecular weight ranging from 13000 to 23000, characterized by its degree of hydrolysis. The hydrolysis degree refers to the conversion rate of acetate groups in the original polyvinyl acetate into hydroxyl groups. This compound is derived from the polymerization of vinyl acetate followed by the removal of acetate groups, resulting in polyvinyl alcohol. With a hydrolysis degree of 87-89%, a significant portion of acetate groups are replaced by hydroxyl groups, enhancing this polymer's capacity to form crosslinked structures in cryogels, making it suitable as a bio-additive.

PVA (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization) [Polyvinyl alcohol (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization); Poly(Ethenol) (Mw 130000, 87-89% hydrolyzed, ～2700 polymerization)] is a biodegradable polymer. It can be blended with various biopolymers and hydrophilic synthetic polymers to enhance the mechanical properties of films.

Polyvinyl alcohol, MW 135000 (PVA, MW 135000), can be used as a pharmaceutical excipient.

Polyvinyl alcohol (Mw 13000-23000, 98% hydrolyzed), also known as PVA, is a water-soluble vinyl polymer that functions as a non-ionic surfactant. It is biodegradable and finds applications in adhesives, coatings, textiles, ceramics, and cosmetics.

Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

BW-1370U87 is a reversible competitive monoamine oxidase-A inhibitor for the study of depression and other CNS disorders.

DW-1350 is an antagonist of LTB4 receptor.

SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.

SMW139 is a selective allosteric antagonist of the P2X7 receptor, exhibiting a Ki value of 32 nM for human P2X7R. In rat liver microsomes, its half-life is 47 minutes. SMW139 is applicable in research related to inflammation, Alzheimer's disease, and multiple sclerosis.

Lw13 is a PROTAC targeting Hsp90, exhibiting maximal degradation efficacy at a concentration of 0.05 μM in Siha cells. Lw13 induces apoptosis and demonstrates potent antitumor activity both in vitro and in vivo.

Coblopasvir is a pan-genotypic non-structural protein 5A (NS5A) inhibitor. It can be used to study chronic hepatitis C virus infection.

Coblopasvir dihydrochloride can be used to study chronic HCV infection and is a pan-genotypic nonstructural protein 5A (NS5A) inhibitor.

Beloxamide is a biochemical.

Dextran T150 MW 150,000 (Dextran D150; Dextran T150 MW 130000-170000) is a glucose polymer with an average molecular weight of 150,000. It features excellent biodegradability and biocompatibility, making it suitable for use in food, pharmaceuticals, cosmetics, and research fields.

Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of fatty acid metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.3,4 |1. Mallatou, H., Pappa, E., and Massouras, T. Changes in free fatty acids during ripening of Teleme cheese made with ewes', goats', cows' or a mixture of ewes' and goats' milk. Int. Dairy J. 13(1-3), 211-219 (2003).|2. Hyang, C.B., Alimova, Y., Myers, T.M., et al. Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Arch. Oral Biol. 56(7), 650-654 (2011).|3. Onkenhout, W., Venizelos, V., van der Poel, P.F.H., et al. Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disorders. Clin. Chem. 41(10), 1467-1474 (1995).|4. Rinaldo, P., O'Shea, J.J., Coates, P.M., et al. Medium-chain acyl-CoA dehydrogenase deficiency. Diagnosis by stable-isotope dilution measurement of urinary n-hexanoylglycine and 3-phenylpropionylglycine. N. Engl. J. Med. 319(20), 1308-1313 (1988).

Ethynyl estradiol 3-β-D-glucuronide is a metabolite of ethynyl estradiol that can be detected in urine.1,2It is used as a marker of estrogen contamination in fresh and saltwater.2 1.Hadd, H.E., Slikker, W., Jr., and Helton, E.D.The synthesis and characterization of the glucopyranosiduronic acids of 17a-ethynylestradiol-17bJ. Steroid Biochem.13(9)1107-1114(1980) 2.Griffith, D.R., Soule, M.C.K., Eglinton, T.I., et al.Steroidal estrogen sources in a sewage-impacted coastal oceanEnviron. Sci.: Processes Impacts18(8)931-1106(2016)