vgsc blocker 1

VGSC blocker-1 is a powerful small molecule that serves as a blocker for the neonatal isoform of the VGSC subtype known as Nav1.5 (nNav1.5). It effectively blocks INa peak currents by 34.9% at a concentration of 1 μM, and demonstrates a 0.3% inhibition of cell invasion at the same concentration in the MDA-MB-231 human breast cancer cell line, without compromising cell viability.

μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), derived from cone snail venom, is a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC) and is used as a research probe for ion channel function and the investigation of neurological disorders like pain [1].

μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA), derived from cone snail venom, functions as a voltage-gated sodium channel (VGSC) blocker and is utilized in researching neurological diseases [1].