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Results for "

vasculature

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    19
    TargetMol | Inhibitors_Agonists
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    TargetMol | Inhibitors_Agonists
Nitrendipine
BAY-E-5009, Bayotensin
T011939562-70-4
Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
  • $32
In Stock
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QTY
Fosbretabulin Disodium
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, Combretastatin A4 Phosphate, Combretastatin A4 disodium phosphate, CA 4P, CA 4DP
T6272168555-66-6
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.
  • $32
In Stock
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QTY
Midodrine hydrochloride
Pro-Amatine
T15773092-17-9
Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier and is therefore not associated with effects on the central nervous system. Midodrine hydrochloride (Pro-Amatine) is the hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties.
  • $39
In Stock
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TargetMol | Inhibitor Sale
ADH-1 trifluoroacetate
Exherin trifluoroacetate
T16081135237-88-5
ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.
  • $37
In Stock
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SBI-425
T168591451272-71-1
SBI-425 is an effective and orally bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP). SBI-425 effectively inhibits TNAP in the vasculature and improves cardiovascular parameters and survival without a detectable change in the bone.
  • $30
In Stock
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BNC-105p free acid
BNC105p free acid
T202724945772-45-2
BNC105P is a benzo[b]furan-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and anti-tumor effects. Upon administration, BNC105P, in its disodium phosphate form, rapidly converts to BNC105. In activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may block spindle formation, cause cell cycle arrest, and dismantle the tumor vasculature. This creates a hypoxic environment, depriving tumor cells of nutrients, leading to apoptosis. Apart from its VDA activity, BNC105P also exerts direct cytotoxic effects on tumor cells by inhibiting tubulin polymerization. Notably, BNC105 is not a substrate for the multidrug-resistant P-glycoprotein (Pgp) transporter.
  • Inquiry Price
10-14 weeks
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Lexibulin
CYT-997
T2090917111-44-5
Lexibulin (CYT-997)(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2 M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.
  • $37
In Stock
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BRL 55834
BRL55834,BRL-55834
T26905131899-25-7
BRL 55834, a potassium channel activator, has shown to relax airways and vasculature in vivo.
  • $1,520
6-8 weeks
Size
QTY
Selexipag
Uptravi, NS-304, ACT-293987
T3216475086-01-2
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).
  • $42
In Stock
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Acetylshikonin
Acetyl shikonin
T5S234324502-78-1
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. 2. Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated. 3. Certain shikonin derivatives(such as Acetylshikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction. 4. Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats. 5. Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge. 6. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
  • $35
In Stock
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pkc-in-4
T616042636771-29-2
PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), with an IC 50 value of 0.52 µM. In vitro studies show that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α and impedes retinal vasculature permeability induced by both VEGF and TNF-α. [1]
  • $2,140
6-8 weeks
Size
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BNC105P
T68273945771-96-0
BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, depriving tumor cells of nutrients and resulting in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization. BNC105 is not a substrate for the multidrug-resistance P-glycoprotein (Pgp) transporter.
  • $1,520
6-8 weeks
Size
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VJ115
T68317929256-79-1
VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis.
  • $1,520
6-8 weeks
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Ginsenoside Rg5
T6S1487186763-78-0
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ameliorate lung inflammation possib
  • $115
In Stock
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TargetMol | Inhibitor Sale
Melafolone
T71032129724-42-1
Melafolone is a natural dual inhibitor of cox-2 and egfr, improving program death 1 (pd-1) checkpoint blockade therapy through normalizing tumor vasculature and pd-l1 downregulation
  • $1,820
8-10 weeks
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Selexipag-d7
TMIH-0520
Selexipag-d7 is a deuterated compound of Selexipag. Selexipag has a CAS number of 475086-01-2. Selexipag(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).
  • Inquiry Price
20 days
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KGFRWR
TP2922
KGFRWR is a short peptide sequence that falls under the category of self-assembling peptides (SAPs). It can self-assemble into functional nanostructures, typically nanofibers, under physiological conditions. KGFRWR is utilized for targeting tumor cells and tumor vasculature, exhibiting antitumor activity.
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P-ESBP-DOX
TP2991
P-ESBP-DOX is an HPMA copolymer-drug conjugate composed of an E-selectin binding peptide and Doxorubicin. It exhibits cytotoxicity against TNFα-activated human vascular endothelial cells (IVEC) with an IC50 of 0.28 μM and is useful for tumor vasculature research.
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TRITC-dextran (MW 20000)
TXB-00543
TRITC-dextran MW 20000 is a fluorescent dye with a molecular weight of 20 kD and an excitation wavelength of 555 nm. This compound is capable of penetrating the vasculature and can be used to label plasma for visualizing the vascular system. Furthermore, TRITC-dextran MW 20000 is employed in drug delivery due to its stability across a wide pH range (pH 2–11) and its resistance to photobleaching.
  • Inquiry Price
7-10 days
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