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Results for "

uterine smooth muscle

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    12
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • Natural Products
    4
    TargetMol | Natural_Products
Isoxsuprine hydrochloride
Duvadilan, Isolait
T0324579-56-6
Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
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Ritodrine hydrochloride
DU21220, Ritodrine HCl, NSC 291565
T143323239-51-2
Ritodrine hydrochloride (NSC 291565) binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions. Ritodrine hydrochloride (NSC 291565) is a phenethylamine derivative with tocolytic activity. Specifically, Ritodrine hydrochloride (NSC 291565) probably activates adenyl cyclase, thereby increasing production of cyclic adenosine monophosphate (cAMP), which in turn enhances the efflux of calcium from vascular smooth muscle cells. A lack of intracellular calcium prevents uterine myometrial contractions. In addition, this agent may directly inactivate myosin light chain kinase, a critical enzyme necessary for the initiation of muscle contractions.
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Sigetin
T346393563-47-1
Sigetin affects the transport of calcium and magnesium in uterine smooth muscle and can be used in fetal development.
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6-8 weeks
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Neuromedin C (trifluoroacetate salt)
T35669
Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulation in mice when administered intradermally at doses ranging from 1 to 300 nmol/site, which is inhibited by the BB2 bombesin receptor agonist RC-3095 and reduced in mast cell-deficient mice. Neuromedin C (3.2 nmol/kg, i.p.) reduces rat glucose consumption by approximately 50% for up to one hour.
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15(S)-15-methyl Prostaglandin E2
15(S)-15-methyl Prostaglandin E2
T3615435700-27-7
15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.
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C16 Globotriaosylceramide (d18:1/16:0)
C16 Globotriaosylceramide (d18:1 16:0)
T36859137896-85-6
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patients with ovarian carcinoma compared to those with benign ovarian tumors or uterine fibroids.
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Oxytocin
α-Hypophamine, Oxytocin (Syntocinon), Oxytocic hormone
T502650-56-6
Oxytocin (Syntocinon) is a mammalian neuropituitary hormone, a pleiotropic hypothalamic peptide and ligand for the oxytocin receptor, which contributes to labor, lactation, and pro-social behavior. Oxytocin has the ability to stimulate mammary secretion of breast milk, promote contraction of uterine smooth muscle during labor, and facilitate mothering.
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Isoxsuprine Free Base
T69303395-28-8
Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
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1-2 weeks
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pdc31
T76565634586-40-6
PDC31 (THG113.31; ILGHXDYK) is a D-amino acid-based oligopeptide that acts as an allosteric and non-competitive inhibitor of the FP Prostaglandin Receptor, used primarily as a smooth muscle contractile agent. It effectively reduces the strength and duration of uterine contractions in vivo, offering potential for preterm labor and primary dysmenorrhea (PD) research. Additionally, PDC31 enhances the Ca2+-dependent large-conductance K+-channel in human myometrial cells [1] [2].
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14-Deoxyandrographolide
T82884176-97-0
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.
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13-Hydroxylupanine hydrochloride
Hydroxylupanine hydrochloride
T834546809-89-8
13-Hydroxylupanine, a characteristic alkaloid of sweet lupins, inhibits ganglionic transmission, reduces cardiac contractility, and induces contraction of uterine smooth muscle [1].
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3-Epioleanolic acid
TN124825499-90-5
3-Epioleanolic acid and oleanonic acid possess varying degrees of agonist activity on uterine smooth muscle with minor changes in the molecular structure affecting its intrinsic activity on uterine muscle.
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