Search Result

Search Results for " uremic "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9189	Iptacopan hydrochloride	Iptacopan HCl,LNP023 hydrochloride	Complement System
	Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity b...		Complement System
T19498	P-Cresyl sulfate potassium	p-Tolyl sulfate potassium salt,p-Cresol sulfate potassium,p-Methylphenyl potassium sulfate,Potassium p-tolyl sulfate	Endogenous Metabolite
	p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) is a prototype protein-bound uremic toxin derived from the metabolites of tyrosine and phenylalanine through liver.		Endogenous Metabolite
T76867	Ravulizumab	ALXN1210	Complement System
	Ravulizumab (ALXN1210) is a humanized monoclonal antibody targeting complement factor 5 that specifically binds to human complement protein C5 with high affinity to block complement activation. Ravulizumab can be used fo...		Complement System
T8509	Danicopan	ACH-4471	Complement System
	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the ...		Complement System
T76660	PTH (1-37) (human)
	pTH (1-37) (human), a fragment of parathyroid hormone (PTH), promotes cAMP formation and enhances alkaline phosphatase activity. Additionally, it fosters growth, elevates bone calcium content, and augments bone mineral d...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of in...

Compounds

Iptacopan hydrochloride

T9189

Synonym: Iptacopan HCl,LNP023 hydrochloride

Target: Complement System

p-Cresyl sulfate potassium

T19498

Synonym: p-Tolyl sulfate potassium salt,p-Cresol sulfate potassium,p-Methylphenyl potassium sulfate,Potassium p-tolyl sulfate

Target: Endogenous Metabolite

Ravulizumab

T76867

Synonym: ALXN1210

Target: Complement System

Danicopan

T8509

Synonym: ACH-4471

Target: Complement System

Indoxyl Sulfate-d5 potassium salt

T70313

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T8150	Nudifloramide	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide	PARP , Endogenous Metabolite
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).		PARP , Endogenous Metabolite
T19866	Indican	NSC-87517,3-Indoxyl-beta-D-glucopyranoside,NSC 87517,NSC87517,Indoxyl-β-D-glucoside	OAT , MRP
	Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.		OAT , MRP
T7523	Guanidinosuccinic acid		Others , Endogenous Metabolite
	Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine.		Others , Endogenous Metabolite
T5289	N-Acetyl-L-arginine dihydrate	N-Ac-L-arg-OH	Others , Endogenous Metabolite
	N-Acetyl-L-arginine dihydrate (N-Ac-L-arg-OH) is one of the guanidino compounds found elevated in the serum of a hemodialyzed renal insufficient (uremic) pediatric population.		Others , Endogenous Metabolite
T21977	P-Cresyl sulfate		Others
	p-Cresyl Sulfate is a major uremic toxin found in the blood of patients with chronic kidney disease (CKD), derived from the metabolites of tyrosine and phenylalanine in the liver.		Others
T8053	N-Acetyl-L-arginine	Ac-Arg-OH	Endogenous Metabolite
	N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-...		Endogenous Metabolite
T4938	Potassium 1H-indol-3-yl sulfate	Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR , Endogenous Metabolite
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...		AhR , Endogenous Metabolite

Natural Products

Nudifloramide

T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

Target: PARP, Endogenous Metabolite

Indican

T19866

Synonym: NSC-87517,3-Indoxyl-beta-D-glucopyranoside,NSC 87517,NSC87517,Indoxyl-β-D-glucoside

Target: OAT, MRP

Guanidinosuccinic acid

T7523

Synonym:

Target: Others, Endogenous Metabolite

N-Acetyl-L-arginine dihydrate

T5289

Synonym: N-Ac-L-arg-OH

Target: Others, Endogenous Metabolite

Target: Endogenous Metabolite

Potassium 1H-indol-3-yl sulfate

T4938

Synonym: Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01075	Von Willebrand Factor/vWF Protein, Human, Recombinant (His)	Human	CHO
	Von Willebrand Factor (VWF) is a multimeric glycoprotein involved in hemostasis in blood, binds receptors on the surface of platelets and in connective tissue, thereby mediating the adhesion of platelets to sites of vasc...
TMPJ-01306	CFHR5 Protein, Human, Recombinant (His)	Human	Human Cells
	Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other...
TMPK-00790	Complement factor H/CFH Protein, Human, Recombinant (His)	Human	HEK293
	Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations...
TMPY-02023	CD46 Protein, Human, Recombinant (His)	Human	HEK293
	CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white bloo...
TMPY-03271	Thrombomodulin Protein, Rat, Recombinant (His)	Rat	HEK293
	Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ...
TMPY-05829	Thrombomodulin Protein, Human, Recombinant (His)	Human	HEK293
	Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the ...
TMPY-04129	Complement factor H/CFH Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens...
TMPY-04141	Complement factor H/CFH Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Complement factor H, also known as H factor 1, and CFH, is a sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defens...