tracking

Ac4ManNAz is an azide-containing metabolic glycoprotein labeling reagent that can selectively modify proteins and can be used for cell labeling, tracking, and proteomic analysis.

GLF16 HCl is a fluorophore-coupled Sudan Black B analog that allows rapid detection, isolation and real-time tracking of senescent cells by fluorescence microscopy and flow cytometry.

N-Ethyl-o-toluidine is a drug with genotoxicity and anticancer potential, exhibiting >70% growth inhibition against yeast strains with specific genetic alterations. It can also serve as an intermediate in dye synthesis.

Mavoglurant (AFQ056) is a potent, selective, non-competitive, and orally active metabotropic glutamate receptor 5 (mGluR5) antagonist with an IC50 of 30 nM, demonstrating greater than 300-fold selectivity over 238 tested targets, and it is widely applied in research on Fragile X syndrome and L-dopa-induced dyskinesias in Parkinson’s disease, while Mavoglurant incorporated alkyne functional group, which enables copper-catalyzed azide–alkyne cycloaddition click chemistry, facilitating target engagement and molecular tracking studies.

Chemodosimeter 1 is designed as a highly selective phosphate ion (PI) sensor capable of demonstrating exogenous and endogenous ATP-catalysed PI production and is the first probe capable of tracking PI production and enrichment through half-channel closure

JC-D7 is a selective fluorescent probe designed for the specific labeling of synthetic polyphosphate in vitro as well as endogenous polyphosphate in living cells, enabling high-sensitivity visualization, spatial tracking, and functional analysis of polyphosphate dynamics in cellular metabolism and signaling research.

ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues.

BOP-JF549 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor® 549. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 549 nm; emission maximum = 571 nm.

BOP-JF646 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor®646. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 655 nm; emission maximum = 672 nm.

HA Peptide TFA is a nine–amino acid synthetic peptide derived from human influenza hemagglutinin (HA) that is widely applied in cell biology and biochemistry research for the isolation, purification, detection, and tracking of target proteins, serving as a versatile epitope tag and experimental reagent in protein expression and interaction studies.

Maurocalcine is a cell-permeable agonist for ryanodine receptor (RyR) subtypes 1, 2, and 3. It enhances [3 H]ryanodine binding to RyR1 with an EC50 of 2558 nM and demonstrates an apparent affinity for RyR2 at 14 nM. This compound is suitable for in vivo cell tracking and other cellular imaging applications [1] [2] [3].

Dual photoCORM 1 (compound 5), a metal-free, photoactive, dual carbon monoxide releasing molecule (CORM), demonstrates efficient cellular uptake and enables real-time tracking of CO release via a colorimetric change in B16F10 cancer cells [1].

Crefmirlimab (IAB22M2C) is a humanized anti-CD8 monoclonal antibody fragment (minibody) designed for PET imaging. Upon radiolabeling (e.g., with 89Zr), it serves as a non-invasive imaging biomarker that binds with high affinity and specificity to the CD8 receptor on CD8+ T cells, enabling real-time, dynamic tracking of T-cell distribution, infiltration, and trafficking in vivo in both preclinical models and clinical studies. It is a critical tool for evaluating the pharmacodynamics of T-cell engaging therapies (such as the GUCY2C-CD3 bispecific antibody PF-07062119) and for investigating the tumor immune microenvironment

MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom

BKN-1, a bifunctional ligand, facilitates the tracking of mtG4s (G-quadruplexes, four-stranded DNA structures containing Hoogsteen bonds) formation via far-red emission and can induce mitochondrial dysfunction. This compound exhibits anti-tumor properties, potentially causing mtDNA loss, damaging mitochondrial integrity, reducing ATP levels, and triggering ROS imbalance, which can lead to apoptosis and autophagy [1].

2-Bromonaphthalene-d7 is a deuterium-labeled version of 2-Bromonaphthalene. Compounds labeled with stable or radioactive isotopes are useful in metabolic analysis, allowing for precise tracking and quantification of individual atoms movements.

AlkyneCholesterol is a modified lipid and serves as a click chemistry reagent containing an alkyne group. In the presence of a copper (Cu) catalyst, the terminal alkyne can engage in highly specific ligation reactions with azide-containing reagents. AlkyneCholesterol is useful for tracking cellular cholesterol metabolism and localization.

DSPE-PEG-Rhodamine, MW 3400 is a PEG lipid conjugated with a fluorescent dye. This amphiphilic polymer can form lipid bilayers in water, useful for encapsulating therapeutic agents like liposomal anti-cancer drugs or mRNA vaccines. Rhodamine's peak absorption wavelength is 570 nm, with peak emission at 595 nm. Imaging techniques facilitate easy tracking of the Rhodamine red dye.

DSPE-PEG-Rhodamine, MW 5000 is a fluorescently labeled PEG lipid. This amphiphilic polymer can form lipid bilayers in water, which are utilized to encapsulate therapeutic agents like liposomal anticancer drugs or [mRNA vaccines]. Rhodamine has a maximum absorption wavelength of 570 nm and a maximum emission wavelength of 595 nm. Imaging techniques allow for easy tracking of the Rhodamine red dye.

Stearic acid-PEG-Rhodamine, MW 2000, is an amphiphilic PEG lipid capable of forming micelles in water. Rhodamine provides staining capabilities for samples and facilitates tracking with fluorescence microscopy, with a maximum absorption wavelength of 570 nm and an emission peak at 595 nm.

Stearic acid-PEG-FITC, MW 2000, is an amphiphilic polyethylene glycol lipid capable of self-assembling into micelles in water. This polymer can encapsulate therapeutic agents. FITC, a green dye, has a peak absorption at 494 nm and maximum emission at 520 nm, and it is suitable for staining biological samples or nanoparticles. Tracking FITC is possible via fluorescence microscopy.

Ceftazidime-d5 is a deuterium-labeled form of Ceftazidime. Compounds labeled with stable or radioactive isotopes are utilized in metabolic studies, allowing for precise tracking and quantification of individual atom movements.

Zoledronic acid-d3 is a deuterium-labeled form of Zoledronic acid. Compounds labeled with stable or radioactive isotopes are utilized in metabolic analyses to enable precise tracking and quantification of individual atom movements.

3-Indoleacrylic acid-d4 is a deuterated marker of 3-Indoleacrylic acid used as a tracer for labeled site tracking.3-Indoleacrylic acid is a tryptophan metabolite produced by Streptococcus spp. It possesses highly potent antialgae activity and is capable of increasing reactive oxygen species (ROS) production and inhibiting nutrient assimilation genes.