thalidomide 4 oh

Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Ethanolamine-Thalidomide-4-OH is an E3 ligase ligand-linker conjugate used in the synthesis of PROTACs, such as [PROTAC BTK Degrader-13].

Thalidomide-1-Me,4-OH is an alcohol-like analogue of Thalidomide. Thalidomide acts as a ligand for E3 ubiquitin ligase, which ubiquitinates proteins, leading to their eventual degradation via proteolysis.

Thalidomide-4-OH-C11-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), comprising Thalidomide-4-OH and the corresponding linker. Thalidomide-4-OH-C11-OH acts as a Cereblon ligand to recruit CRBN protein and serves as a key intermediate for synthesizing complete PROTAC molecules, such as PROTAC GPX4 degrader-4.

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the BCL6 ligand-2, the E3 ubiquitin ligase ligand Thalidomide-4-OH, and a PROTAC Linker. The configuration notably features a conjugate of the E3 ubiquitin ligase ligand and the Linker, designated as 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione.

dCE-2, a PROTAC compound, specifically targets CBP/EP300. It comprises several key components: the E3 ubiquitin ligase ligand Thalidomide-4-OH, the PROTAC linker tert-Butyl 11-aminoundecanoate, and the PROTAC target protein ligand EP300/CBP ligand 2. The activity of the target protein ligand is regulated by EP300/CBP ligand 1. Additionally, the conjugate of the E3 ubiquitin ligase ligand and linker is denoted as Thalidomide-NH-C10-Boc.

PROTAC HDAC8 Degrader-2 (compound 32a) acts as a degrader for HDAC8 with a DC50 of 8.9 nM and for HDAC6 with a DC50 of 14.3 nM. This compound is composed of a PROTAC target protein ligand HDAC8 ligand 1, an E3 ligase ligand thalidomide-4-OH, and PROTAC Linker 1,5-diaminopentane. The complex includes an E3 ubiquitin ligase ligand linked with the linker, specifically thalidomide-NH-C5-NH2.

PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.