thalidomide 4 oh

Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Ethanolamine-Thalidomide-4-OH is an E3 ligase ligand-linker conjugate used in the synthesis of PROTACs, such as [PROTAC BTK Degrader-13].

Thalidomide-1-Me,4-OH is an alcohol-like analogue of Thalidomide. Thalidomide acts as a ligand for E3 ubiquitin ligase, which ubiquitinates proteins, leading to their eventual degradation via proteolysis.

Thalidomide-4-OH-C11-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), comprising Thalidomide-4-OH and the corresponding linker. Thalidomide-4-OH-C11-OH acts as a Cereblon ligand to recruit CRBN protein and serves as a key intermediate for synthesizing complete PROTAC molecules, such as PROTAC GPX4 degrader-4.

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the BCL6 ligand-2, the E3 ubiquitin ligase ligand Thalidomide-4-OH, and a PROTAC Linker. The configuration notably features a conjugate of the E3 ubiquitin ligase ligand and the Linker, designated as 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-hydroxyethoxy)ethyl)amino)isoindoline-1,3-dione.

dCE-2, a PROTAC compound, specifically targets CBP EP300. It comprises several key components: the E3 ubiquitin ligase ligand Thalidomide-4-OH, the PROTAC linker tert-Butyl 11-aminoundecanoate, and the PROTAC target protein ligand EP300 CBP ligand 2. The activity of the target protein ligand is regulated by EP300 CBP ligand 1. Additionally, the conjugate of the E3 ubiquitin ligase ligand and linker is denoted as Thalidomide-NH-C10-Boc.

PROTAC HDAC8 Degrader-2 (compound 32a) acts as a degrader for HDAC8 with a DC50 of 8.9 nM and for HDAC6 with a DC50 of 14.3 nM. This compound is composed of a PROTAC target protein ligand HDAC8 ligand 1, an E3 ligase ligand thalidomide-4-OH, and PROTAC Linker 1,5-diaminopentane. The complex includes an E3 ubiquitin ligase ligand linked with the linker, specifically thalidomide-NH-C5-NH2.

PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2 BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.