taf1

CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).

GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.

BAY-299 is an effecitve inhibitor of the bromodomain and PHD finger family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L with IC50s of 67 nM, 8 nM, and 106 nM, respectively.

ZS3-046 is a TAF1 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of TAF1. It can activate p53 and induce apoptosis in acute myeloid leukemia (AML) cells. Additionally, ZS3-046 demonstrates anti-tumor efficacy in AML xenograft mouse models.

UMB-32 is a potent and selective BRD4 inhibitor, demonstrating an affinity for BRD4 with a dissociation constant (K d) of 550 nM and an inhibitory concentration 50 (IC 50) of 637 nM. Moreover, UMB-32 exhibits effectiveness against TAF1, a bromodomain-containing transcription factor [1].

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 μM).

BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+ cells, and K562 cells with respective IC50 values of 1.0 µM, 10.4 µM, and 10.0 µM.

CeMMEC1 is a compound derived from N-methylisoquinolinone that inhibits the second bromodomain of TAF1.