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Results for "

tachykinin nk1 receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    36
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    14
    TargetMol | Peptide_Products
  • Natural Products
    1
    TargetMol | Natural_Products
Vofopitant dihydrochloride
GR 205171A, Vofopitant 2HCl
T13329L168266-51-1In house
Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively. It is a potential compound for the treatment of pathological vomiting.
  • Inquiry Price
10-14 weeks
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MEN11467
T12000214487-46-4In house
MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.
    6-8 weeks
    Inquiry
    Fosaprepitant dimeglumine
    MK-0517, L785298, Fosaprepitant dimeglumine salt
    T1790265121-04-8
    Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, a water-soluble, N-phosphorylated prodrug of aprepitant with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent selectively binds to human substance P neurokinin 1 (NK1) receptors in the central nervous system (CNS), inhibiting receptor binding of endogenous substance P and preventing substance P-induced emesis.
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    Aprepitant
    MK-869, MK-0869, L-754030, Aprepitant`
    T1743170729-80-3
    Aprepitant is a Substance P Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
    • Inquiry Price
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    TargetMol | Citations Cited
    Maropitant
    T7209147116-67-4
    Maropitant is a selective neurokinin (NK1) receptor antagonist.
    • Inquiry Price
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    TargetMol | Inhibitor Sale
    Netupitant
    Ro 67-31898 000, CID 6451149
    T6905290297-26-6
    Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM).
    • Inquiry Price
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    L-732138
    T8235148451-96-1
    L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
    • Inquiry Price
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    TargetMol | Inhibitor Sale
    CS-003 Free base
    T10892191672-52-3
    CS-003 free base (CS-003) is a triple tachykinin receptor antagonist with high affinity for human (neurokinin) NK1, NK2 and NK3 receptors, with Ki values of 2.3 nM and 0.54 nM, respectively And 0.74 nM. CS-003 free base (CS-003) has therapeutic effects on
    • Inquiry Price
    3-6 months
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    [Sar9,Met(O2)11]-Substance P acetate
    [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)
    TP1369L
    [Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P acetate is the sole to produce grooming.
    • Inquiry Price
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    RP 67580
    T23251135911-02-3
    tachykinin NK1 receptor antagonist
    • Inquiry Price
    6-8 weeks
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    GR 64349
    TP2023137593-52-3
    Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
    • Inquiry Price
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    [Tyr6,D-Phe7,D-His9]-Substance P (6-11)
    TP2810145194-26-9
    [Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin NK1 receptor antagonist that can counteract histamine-induced hyperalgesia.
    • Inquiry Price
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    TAK-637
    TAK 637
    T28917217185-75-6
    TAK-637 is a tachykinin 1 (NK1) receptor antagonist.
    • Inquiry Price
    10-14 weeks
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    Hemokinin 1, human TFA
    T75840
    Hemokinin 1, human TFA acts as a selective full agonist at the tachykinin neurokinin 1 (NK1) receptor, while also being a full agonist at NK2 and NK3 receptors. It is capable of inducing opioid-independent analgesia [1] [2].
    • Inquiry Price
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    Elinzanetant
    T38144929046-33-3
    Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.
    • Inquiry Price
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    Hemokinin 1, human
    Hemokinin 1 (human)
    TP1899491851-53-7
    Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihyperte
    • Inquiry Price
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    [Sar9,Met(O2)11]-Substance P
    Bhsar-sp, NA
    T7828110880-55-2
    [Sar9,Met(O2)11]-Substance P (NA) is an NK1 receptor agonist.
    • Inquiry Price
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    CAM 4515
    T70137183023-29-2
    CAM 4515 is a nonpeptide tachykinin NK1 receptor antagonist.
    • Inquiry Price
    6-8 weeks
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    sdz nkt 343
    T23345180046-99-5
    human tachykinin NK1 receptor antagonist
    • Inquiry Price
    6-8 weeks
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    men 10207
    MEN-10207, MEN10207
    T24446126050-12-2
    MEN 10207 is an antagonist of tachykinin.
    • Inquiry Price
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    Substance P
    Neurokinin P
    TP108733507-63-0
    Substance P (Neurokinin P) (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family.
    • Inquiry Price
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    GR 82334
    TP2024129623-01-4
    Tachykinin NK1 receptor antagonist.
    • Inquiry Price
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    GR-73632
    TP1572133156-06-6
    Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens).
    • Inquiry Price
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    Hemokinin 1 (human) acetate(491851-53-7 free base)
    TP1899L1
    Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B
    • Inquiry Price
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