t8853

NH2-PEG3-VC-PAB-MMAE is a drug-linker conjugate for ADC, which combines a cleavable ADC linker (NH2-PEG3-VC-PAB) with a potent tubulin inhibitor Monomethylauristatin E (MMAE). It is mainly used in the synthesis of antibody-drug conjugates (ADCs).

PRMT5-IN-44 (compound 12) is an inhibitor of PRMT5, specifically utilized in cancer research.

I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.

T-10418 is a highly potent and selective G2A/GPR132 agonist (EC50 = 0.82 μM) that enhances TRPV1 responses in mouse primary sensory neurons, making it suitable for studying neuropathic pain and inflammation.

Antiviralagent 56 (Compound 4) is an antiviral agent with anti-HIV activity.

17β-HSD5 inhibitor 3 (Compound 31) is an orally effective inhibitor of 17β-HSD5, exhibiting an IC50 of 69 nM.

8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.

AZD-9574-acid (70D) functions as an inhibitor of PPAR-1 and is utilized in the synthesis of PROTAC (CAS 2923686-70-6).

ULK-101 is a potent and selective inhibitor of ULK1 (IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.