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Results for "
sx-517
" in TargetMol Product Catalog- Inhibitors & Agonists1
SX-517
SX517, SX 517
T288931240494-13-6
SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca²⁺ flux (IC₅₀ = 38 nM), antagonises CXCL-8-induced [(³⁵)S]GTPγS binding (IC₅₀ = 60 nM), and suppresses ERK1/2 phosphorylation.
- $149
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