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Search Result

Search Results for " steatosis "

Targets

Others

25

Compounds

10

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
TD0093 Oil Red O Others
The dry dye Oil red O is used for the preparation of a staining solution that can be used for the detection of lipids in histological cryo sections.
T9193 ACH-000143 Melatonin Receptor , MT Receptor
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T12580 PTUPB COX , Epoxide Hydrolase
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T8732 CTPI-2 Others , Mitochondrial Metabolism
CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha...
T60004 SRI-37330 Others
SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis.
T77245 Mannan Endogenous Metabolite
Mannan is isolated from algae, mushrooms, yeast and higher plants and acts as an immunomodulator.Mannan inhibits the pro-inflammatory activity of hepatic macrophages (M1 lineage) with protective effects against many live...
T60033 SBI993 Others
SBI993 is an analog of SBI-477 and can be used as a biomarker to confirm the expected action of MondoA target gene expression in vivo. SBI993 reduces muscle TAG levels and hepatic steatosis.
T9186 Ervogastat PF-06865571 Transferase
Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).
T23097 O-1602 O1602,O 1602 Cannabinoid Receptor , Calcium Channel
O-1602 is a novel GPR55 agonist, an atypical cannabinoid associated with the central nervous system and obesity, and is a candidate compound for the treatment of cystitis.O-1602 promotes hepatic steatosis through GPR55 a...
T68974 MHY553
MHY 553 is a PPARα agonist that improved aged-induced hepatic steatosis.
T35441 Tripalmitolein
Tripalmitolein is a triacylglycerol that contains palmitoleic acid at the sn-1, sn-2, and sn-3 positions. It reduces red blood cell deformability in a concentration-dependent manner in a Reid's filtration assay. Hepatic ...
T63697 THR-β agonist 3
THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has shown research potential for metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and...
T62594 THR-β agonist 2
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has potential for studies of metabolic diseases (e.g. obesity, hyperlipidaemia, hypercholesterolaemia, diabetes and other conditions such as steatosis and non...
T35620 Ethoxyquin Dimer
Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induc...
T36860 C22 Sphingomyelin (d18:1/22:0) C22 Sphingomyelin (d18:1/22:0)
C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyel...
T35444 1-Pentadecanoyl-rac-glycerol
1-Pentadecanoyl-rac-glycerol is a monoacylglycerol that contains pentadecanoic acid at the sn-1 position. It has been found in wheat bran extracts.1 1-Pentadecanoyl-rac-glycerol levels are increased in a HepaRG cell-base...
T35636 SHS4121705
SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis...
T21978 P-nitro-Pifithrin-α
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Mor...
T74996 FXR agonist 3
FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ...
T72034 LI-2242 Others
LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the ...
T72889 FXR agonist 4
FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ...
T63515 THR-β agonist 4
THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has shown research potential for metabolic diseases such as hyperlipidemia, obesity, hypercholesterolemia, diabetes and other conditions such as steatosis and...
T64144 FXR antagonist 1
FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation...
T35816 ZLY032
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and...
T64692 AMY-101 acetate
Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exe...
Cat No. Product Name Synonyms Targets
T7992 4-Hydroxyflavanone NO Synthase
4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects
T3888 Scopolin Murrayin,Scopoloside Sirtuin
Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for...
T0746 Orotic acid Vitamin B13,6-Carboxyuracil Nucleoside Antimetabolite/Analog , Dehydrogenase , Endogenous Metabolite
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
T3271 Orotic acid zinc Orotic acid zinc salt dihydrate,Zinc Orotate Nucleoside Antimetabolite/Analog , Others , Endogenous Metabolite
Orotic acid zinc (Zinc Orotate) salt dihydrate is an intermediate product in pyrimidine synthesis.
TN6751 1-HEXACOSANOL NPC1L1 , AMPK
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.
T5S0384 Rhapontin Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside Apoptosis , Others
1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as ...
T6S0221 Eriocitrin eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside Apoptosis , Carbonic Anhydrase
1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet....
T6S2391 L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid Others , HIV Protease
L-Chicoric Acid (trans-Caffeoyltartaric acid) has been shown to inhibit hyaluronidase and HIV-1 integrase, and to possess phagoeytosis stimulatory activity in vitro and in vivo and antiviral acitivy. L-Chicoric acid may ...
T30784 Cedrene AI3-51328,AI3 51328,AI351328
Cedrene can regulate hepatic steatosis via the cAMP-PKA pathway.
T35624 Ajoene
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...

Natural Products

4-Hydroxyflavanone
T7992
Synonym:
Target: NO Synthase
Scopolin
T3888
Synonym: Murrayin,Scopoloside
Target: Sirtuin
Orotic acid
T0746
Synonym: Vitamin B13,6-Carboxyuracil
Target: Nucleoside Antimetabolite/Analog, Dehydrogenase, Endogenous Metabolite
Orotic acid zinc
T3271
Synonym: Orotic acid zinc salt dihydrate,Zinc Orotate
Target: Nucleoside Antimetabolite/Analog, Others, Endogenous Metabolite
1-HEXACOSANOL
TN6751
Synonym:
Target: NPC1L1, AMPK
Rhapontin
T5S0384
Synonym: Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside
Target: Apoptosis, Others
Eriocitrin
T6S0221
Synonym: eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside
Target: Apoptosis, Carbonic Anhydrase
L-Chicoric Acid
T6S2391
Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,dicaffeoyltartaric acid
Target: Others, HIV Protease
Cedrene
T30784
Synonym: AI3-51328,AI3 51328,AI351328
Target:
Ajoene
T35624
Synonym:
Target:

Recombinant Proteins

Species：
Human (1)
Mouse (1)
Rat (1)
Expression System：
Baculovirus-Insect Cells (3)
Tag：
His (2)
His,GST (1)
Cat No. Product Name Species Expression System
TMPY-00386 GLT8D2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes. GLT8D2 expression increased in steatosis HepG2 cells compared with that in normal HepG2 cells. GLT8D2 participated in nonalcoholic ...
TMPY-04445 PDK4 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient...
TMPY-01099 GPT Protein, Rat, Recombinant (His) Rat Baculovirus-Insect Cells
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfa...
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