sp-camps

Rp-cAMPS TEA salt is a cAMP-dependent protein kinase (PKA) activator.

Sp-cAMPS triethylamine, a cAMP analog, serves as a potent activator of cAMP-dependent PKA I and II, and acts as a competitive inhibitor of phosphodiesterase (PDE3A) with a K i of 47.6 µM. Additionally, it binds the PDE10 GAF domain with an EC 50 of 40 μM [1] [2] [3].

Sp-cAMPS-AM is an analog of cAMP that functions by penetrating cells and liberating its parent polar structure, Sp-cAMPS, thereby inducing PKA activation and CREB phosphorylation.

Sp-8-Br-cAMPS, an analog of cAMP, acts as an agonist for activating protein kinase A (PKA) with an EC50 of 360 nM. It inhibits T-cell proliferation and non-self responses in the hematocytes of Lepidopteran larvae.

Sp-8-pCPT-2'-O-Me-cAMPS acts as an activator of EPAC and is utilized in research related to endocrine metabolism.

Sp-8-CPT-cAMPS is a powerful and specific cAMP analog that activates cAMP-dependent protein kinase A (PKA I and PKA II) selectively and effectively. It exhibits a 153-fold preference for site A of RI over site A of RII, and a 59-fold preference for site B of RII over site B of RI.

Sp-8-Br-2'-O-Me-cAMPS is a cAMP analog and an EPAC activator commonly used in metabolic-related research.

Sp-6-Phe-cAMPS is an effective activator of cAMP-dependent protein kinase (PKA) with site selectivity and membrane permeability. It does not activate the exchange factors directly stimulated by cAMP, making it suitable as a negative control for Epac. Sp-6-Phe-cAMPS can also be utilized in research on neurodegenerative diseases.

Sp-2-Cl-cAMPS serves as an agonist for PKA, boasting enhanced membrane permeability and stability against phosphodiesterases. This compound exhibits antimalarial activity, inhibiting the proliferation of the malaria parasite Plasmodium falciparum with an EC50 of 4 µM. Furthermore, Sp-2-Cl-cAMPS binds to the purified regulatory subunit of PfPKA (PfPKAr) with a Ki of 1.3 µM.

Sp-8-Cl-cAMPS, as a derivative and analogue of cAMP, can inhibit the growth of various human tumor cells, such as leukemia cells HL-60 and colon cancer cells LS-174T, with an IC50 range of 8-100 μM. In addition, this compound can activate protein kinase cAKI and cAKII, with Ka values of 0.25 μM and 3.2 μM, respectively.

Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3].

Rp-cAMPS competitively inhibits the cAMP-induced activation of cAMP-dependent protein kinase (PKA).

Sp-8-Cl-cAMPS, an analogue of cAMP and a derivative of Sp-8-Cl-cAMP, inhibits the growth of human leukemia cells (HL-60) and colon cancer cells (LS-174T) with an IC50 ranging from 8-100 μM. Additionally, it activates protein kinases cAKI and cAKII, with Ka values of 0.25 μM and 3.2 μM, respectively.