skin-structure

Omadacycline (Amadacycline), a new tetracycline antibiotic, can inhibit the 30s subunit of bacterial ribosome.

Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial drug under development for treating acute bacterial skin and skin structure infections, as well as community-acquired pneumonia.

Afabicin is an antibiotic targeting Staphylococcus aureus, exhibiting highly effective inhibitory activity against both susceptible and methicillin-resistant (MRSA) S. aureus strains. It is used to treat acute bacterial skin and skin structure infections. Afabicin is the prodrug of Debio1452.

Tuaminoheptane was originally developed as a nasal decongestant and belongs to the class of sympathomimetics and vasoconstrictors. It exhibits decongestant and stimulating effects by inhibiting and releasing norepinephrine. Unlike phenethylamine-based norepinephrine releasers, Tuaminoheptane has a unique chemical structure. Additionally, it may cause contact dermatitis due to its potential to irritate the skin by inhibiting volume-regulated anion channels, which limits its effectiveness as a decongestant.

Tuaminoheptane is a sympathomimetic and vasoconstrictor that was once used as a nasal decongestant. It works by inhibiting and accelerating the release of norepinephrine, a mechanism that likely underpins its decongestant and stimulating effects. Unlike other norepinephrine-releasing agents such as phenethylamines, Tuaminoheptane's chemical structure lacks an aromatic ring. Additionally, it acts as a skin irritant and may cause contact dermatitis by inhibiting volume-regulated cation channels, which limits its utility as a decongestant.

Cefdinir is an advanced broad-spectrum cephalosporin antibacterial compound approved for treating community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, acute maxillary sinusitis, pharyngitis tonsillitis, acute bacterial otitis media, and uncomplicated skin and skin structure infections in both adult and pediatric patients.

Acorafloxacin is a broad-spectrum fluoroquinolone antibacterial drug being developed for the treatment of acute bacterial skin and skin structure infections and community-acquired pneumonia.

Ceramide 1 A is a waxy lipid compound that is a lipid in the top skin layer. It has a special molecular structure because it contains a linoleic acid linked to a long chain omega-hydroxy acid.

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin. [Matreya, LLC. Catalog No. 1321] 1.Ito, M., Kurita, T., and Kita, K.A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycosphingolipids as well as sphingomyelin to produce their lyso formsJ. Biol. Chem.270(41)24370-24374(1995) 2.Nixon, G.F., Mathieson, F.A., and Hunter, I.The multi-functional role of sphingosylphosphorylcholineProg. Lipid Res.47(1)62-75(2008) 3.Im, D.-S., Clemens, J., Macdonald, T.L., et al.Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptorsBiochemistry40(46)14053-14060(2001) 4.Meyer zu Heringdorf, D., Himmel, H.M., and Jakobs, K.H.Sphingosylphosphorylcholine-biological functions and mechanisms of actionBiochim. Biophys. Acta1582(1-3)178-189(2002) 5.Rodriguez-Lafrasse, C., and Vanier, M.T.Sphingosylphosphorylcholine in Niemann-Pick disease brain: Accumulation in type A but not in type BNeurochem. Res.24(2)199-205(1999)

Transdermal Peptide is a 11-amino acid peptide, binds to Na+ K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules. Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts with the C-terminus of ATP1B1 in yeast and mammalian cells. The interaction affects the expression and localization of ATP1B1 and epidermal structure, but can be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain. Inhibition of Transdermal Peptide binding to ATP1B1 causes decreased delivery of macromolecular drugs across the skin[1]. [1]. Wang C, et al. Role of the Na(+) K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67.

Zifanocycline (KBP-7072), a third-generation semisynthetic aminomethylcycline antibiotic, inhibits bacterial ribosome function, displaying broad-spectrum antibacterial activity in vitro against both Gram-positive and Gram-negative bacteria, notably multidrug-resistant strains. It is formulated for oral and injectable use, targeting research on acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections [1] [2].

Ceftaroline fosamil hydrate acetate is a powerful cephalosporin antibiotic that exhibits broad-spectrum efficacy against both Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative bacteria. It possesses anti-infective properties suitable for studying complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) [1] [2] [3].

Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability that targets bacterial ribosomes to impede their function. Displaying a broad spectrum of in vitro antimicrobial efficacy, it combats both Gram-positive and Gram-negative bacteria, including numerous multidrug-resistant strains. Clinical investigations focus on treating acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections [1] [2].

Type I Collagen (from Bovine) plays a critical role in the structure and function of skin, bones, and tendons. It can mimic the extracellular matrix (ECM) and is suitable for both 2D and 3D cell culture applications.

Type I Collagen ( from Chick) possesses distinct immunological properties and plays a crucial role in the structure and function of skin, bones, and tendons. It can be utilized as a stimulating antigen for T cells in in vitro culture systems.

Type I Collagen (from Human) exhibits unique immunological properties and plays a vital role in the structure and function of skin, bones, and tendons. Additionally, it can serve as a stimulatory antigen for T cells in in vitro culture systems.

Type I Collagen, T Cell Grade, from Mouse possesses unique immunological properties and plays a significant role in maintaining the structure and function of skin, bones, and tendons. Additionally, it can serve as a stimulatory antigen for T cells in in vitro culture systems.

Type I Collagen, T Cell Grade, from Porcine possesses unique immunological properties, playing a crucial role in the structure and function of skin, bones, and tendons. Additionally, it serves as a stimulatory antigen for T cells in in vitro culture systems.

Type I Collagen ( from Rat) possesses unique immunological properties crucial for the structure and function of skin, bones, and tendons. It can be used as a stimulatory antigen for T cells in in vitro culture systems.

Collagen (bovine skin) plays a crucial role in the structure and function of skin, bones, and tendons. Collagen derived from bovine skin can serve as a scaffold for biomimetic collagen mineralization.

Type I collagen(from bovine skin) plays a crucial role in the structure and function of skin, bones, and tendons. Type I collagen effectively stimulates angiogenesis both in vitro and in vivo. This immunization-grade collagen is suitable for inducing antibody production.