sappβ

LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.

Sodium pyrophosphate (Disodium pyrophosphate), an inorganic food additive, exhibits potential hematotoxic and immunotoxic effects [1].

4-O-Methylepisappanol is a useful organic compound for research related to life sciences and the catalog number is T126375.

Sappanol is a useful organic compound for research related to life sciences and the catalog number is T126391.

3'-Deoxy-4-O-methylepisappanol is a useful organic compound for research related to life sciences and the catalog number is T126471.

Sappanone B is a useful organic compound for research related to life sciences and the catalog number is T126481.

Caesappanin C, extracted from the heartwood of Indonesian Caesalpinia sappan L., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro.

1. Protosappanin B (Q-100961) significantly increases cell viability, inhibits cell apoptosis and up-regulates the expression of growth-associated protein 43. 2. Protosappanin B induces the degradation of p53 protein, via activation of a MDM2-dependent ubiquitination process.

Cyclic PSAP peptide (DWLPK) possesses properties akin to those of a therapeutic agent, demonstrating the potential to inhibit metastasis and suppress tumor growth in vivo [1].

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

Sappanone A is a high isoflavanone that exhibits anti-inflammatory effects by modulating Nrf2.Sappanone A attenuates allergic airway inflammation in ovalbumin-induced asthma.

Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).

3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.

3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

'3'-Deoxy-4-O-methylsappanol exhibits moderate cytotoxicity against cultured human melanoma HMV-II cells, with an IC50 value of 872.0 µM ± [2.4].

4-O-Methylsappanol shows activity against this fungus against Beauveria bassiana.

Protosappanin A dimethyl acetal shows significant xanthine oxidase inhibitory activity in a concentration-dependent manner.

10-O-Methylprotosappanin B, a natural product of Caesalpinia (Fabaceae), has the catalog number TN5673 and the CAS number 111830-77-4. It can be used as a reference standard.

Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.

β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to Aβ1-42. This compound also associates with sAPPα and sAPPβ and has the potential to serve as an additional biomarker for Alzheimer's disease (AD), complementing existing markers [1].