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Results for "
rovatirelin
" in TargetMol Product Catalog- Inhibitors & Agonists2
Rovatirelin
S-0373, S0373, S 0373, KPS-0373
T34399204386-76-5In house
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine and dopamine neurotransmission.
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Rovatirelin trihydrate
Rovatirelin hydrate [JAN], Rovatirelin hydrate, G5O9D3ZK7O
T202463879122-87-9
Rovatirelin (also known as S-0373) is a novel synthetic compound that mimics the action of thyrotropin-releasing hormone (TRH). This compound exhibits a higher affinity for human TRH receptors (Ki=702nM) compared to taltirelin (Ki=3877nM). In acutely isolated norepinephrine neurons of the rat locus coeruleus (LC), rovatirelin enhances the firing of spontaneous action potentials. Additionally, rovatirelin increases motor activity and may offer potential therapeutic benefits as an oral treatment for patients with SCD.
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